Antiviral oseltamivir is not removed or degraded in normal sewage water treatment: implications for development of resistance by influenza A virus. [PDF]
PLoS ONE, 2007 Oseltamivir is the main antiviral for treatment and prevention of pandemic influenza. The increase in oseltamivir resistance reported recently has therefore sparked a debate on how to use oseltamivir in non pandemic influenza and the risks associated ...
Jerker Fick +6 more
doaj +1 more source
Characterization of oseltamivir-resistant 2009 H1N1 pandemic influenza A viruses. [PDF]
PLoS Pathogens, 2010 Influenza viruses resistant to antiviral drugs emerge frequently. Not surprisingly, the widespread treatment in many countries of patients infected with 2009 pandemic influenza A (H1N1) viruses with the neuraminidase (NA) inhibitors oseltamivir and ...
Maki Kiso +11 more
doaj +1 more source
mBio, 2022 Influenza viruses cause significant morbidity and mortality worldwide but can be treated with antiviral drugs. In 2018, a highly effective antiviral drug, baloxavir marboxil, was licensed.
Paulina Koszalka +4 more
semanticscholar +1 more source
The novel carboxylesterase 1 variant c.662A>G may decrease the bioactivation of oseltamivir in humans. [PDF]
PLoS ONE, 2017 Human carboxylesterase 1 (CES1) is a serine esterase that hydrolyses various exogenous and endogenous compounds including oseltamivir, a prodrug used to treat influenza. A novel CES1 c.662A>G single nucleotide polymorphism (SNP) was predicted to decrease
Jaeseong Oh +7 more
doaj +1 more source
Potential of antiviral drug oseltamivir for the treatment of liver cancer
International Journal of Oncology, 2021 Liver cancer is a leading cause of cancer-related mortality globally. Since hepatitis virus infections have been strongly associated with the incidence of liver cancer, studies concerning the effects of antiviral drugs on liver cancer have attracted ...
Pei-Ju Huang +5 more
semanticscholar +1 more source
Saudi Pharmaceutical Journal, 2023 Background: Oseltamivir has been used as adjunctive therapy in the management of patients with COVID-19. However, the evidence about using oseltamivir in critically ill patients with severe COVID-19 remains scarce.
Ohoud Aljuhani +19 more
doaj +1 more source
Early oseltamivir reduces risk for influenza-associated aspergillosis in a double-hit murine model
Virulence, 2021 Invasive pulmonary aspergillosis (IPA) is a life-threatening fungal infection occurring mainly in immunocompromised patients. We recently identified IPA as an emerging co-infection with high mortality in critically ill, but otherwise immunocompetent ...
Laura Seldeslachts +14 more
semanticscholar +1 more source
Frontiers in Pharmacology, 2022 Background: As a cause of respiratory tract infections in humans, influenza remains with high morbidity and mortality, with associated significant healthcare burden and increased financial burden.
Yingying Peng +16 more
doaj +1 more source
Generation of an Induced Pluripotent Stem Cell-Derived Alveolar Type II In Vitro Model to Study Influenza A Virus Infection and Drug Treatments. [PDF]
Adv Healthc MaterPatient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Gauthier L +7 more
europepmc +2 more sources
Oseltamivir Treatment for Children with Influenza-Like Illness in China: A Cost-Effectiveness Analysis. [PDF]
PLoS ONE, 2016 BACKGROUND:Influenza is a common viral respiratory infection that causes epidemics and pandemics in the human population. Oseltamivir is a neuraminidase inhibitor-a new class of antiviral therapy for influenza.
Kunling Shen +3 more
doaj +1 more source