TFEB-mediated autophagy stimulation as an anabolic strategy for bone: insights from TFEB activation in the osteoblast lineage [PDF]
Autophagy ReportsAutophagy in the osteoblast lineage is essential for bone formation and skeletal homeostasis, yet the mechanisms through which it supports bone formation remain unclear.
Melda Onal
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miR-452-3p inhibited osteoblast differentiation by targeting Smad4 [PDF]
PeerJ, 2021 Osteoblast differentiation is a complex process that is essential for normal bone formation. A growing number of studies have shown that microRNAs (miRNAs) are key regulators in a variety of physiological and pathological processes, including ...
Ming Wu +6 more
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SLC38A2 provides proline and alanine to regulate postnatal bone mass accrual in mice
Frontiers in Physiology, 2022 Amino acids have recently emerged as important regulators of osteoblast differentiation and bone formation. Osteoblasts require a continuous supply of amino acids to sustain biomass production to fuel cell proliferation, osteoblast differentiation and ...
Leyao Shen +4 more
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Constitutive activation of Gli2 impairs bone formation in postnatal growing mice. [PDF]
PLoS ONE, 2013 Indian hedgehog (Ihh) signaling is indispensable for osteoblast differentiation during endochondral bone development in the mouse embryo.
Kyu Sang Joeng, Fanxin Long
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Microorganisms, 2021 Osteoblast differentiation is important for the development of bone and the maintenance of bone density. Propionibacterium freudenreichii is a probiotic with an anti-inflammatory property.
Jiah Yeom, Seongho Ma, Young-Hee Lim
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BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation. [PDF]
PLoS ONE, 2013 Bone morphogenetic proteins (BMPs) regulate many aspects of skeletal development, including osteoblast and chondrocyte differentiation, cartilage and bone formation, and cranial and limb development.
Takashi Matsumoto +10 more
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Core-binding factor beta is required for osteoblast differentiation during fibula fracture healing
Journal of Orthopaedic Surgery and Research, 2021 Background Growing evidence has implicated core-binding factor beta (Cbfb) as a contributor to osteoblast differentiation, which plays a key role in fracture healing. Herein, we aimed to assess whether Cbfb affects osteoblast differentiation after fibula
Tuanmao Guo +6 more
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From osteoblast to osteoclast: new insights of Yin-Yang theory in bone remodeling
World Journal of Traditional Chinese Medicine, 2015 Yin-Yang theory plays critical role in traditional Chinese medicine (TCM) science. However, there are many competing interpretations of Yin-Yang theory in the context with the development in biology, and no consensus has been established.
Dong-Feng Zhao +7 more
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Cell Transitions Contribute to Glucocorticoid-Induced Bone Loss
Cells, 2023 Glucocorticoid-induced bone loss is a toxic effect of long-term therapy with glucocorticoids resulting in a significant increase in the risk of fracture.
Xiaojing Qiao +10 more
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Regulation of osteoblast differentiation mediated by BMP, Notch, and CCN3/NOV
Japanese Dental Science Review, 2008 Osteoblasts originate from common progenitors, which are capable of differentiating into other mesenchymal cell lineages such as chondrocytes, myoblasts and adipocytes.
Akira Yamaguchi +4 more
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