Results 1 to 10 of about 197,424 (329)

TFEB-mediated autophagy stimulation as an anabolic strategy for bone: insights from TFEB activation in the osteoblast lineage [PDF]

Autophagy Reports
Autophagy in the osteoblast lineage is essential for bone formation and skeletal homeostasis, yet the mechanisms through which it supports bone formation remain unclear.
Melda Onal
doaj   +2 more sources

The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation [PDF]

, 2010
Background: Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation.
AE Hoffman, AM Parfitt, Arndt F. Schilling, AV Neutzsky-Wulff, B Zheng, CA Feillet, CJ Rosen, DA Corral, Dong-Yan Jin, E Grundberg, Erik Maronde, G Hampp, Gijsbertus van der Horst, GT van der Horst, H Oster, H Viswambharan, Isabelle Schmutz, J Liu, JM Gimble, K Bae, K Henriksen, K Shidara, L Fu, L Fu, LP Shearman, M Amling, M Merrow, M Rucinski, M Zaidi, MH Hastings, Michael Amling, R Dallmann, R Spanagel, S Sato, S Stephan, S Vaira, S Yoo, S Zvonic, Sebastian Seitz, SM Reppert, Thorsten Schinke, U Albrecht, Urs Albrecht, V Pilorz, X Wu, X Wu, X Wu   +46 more
core   +28 more sources

miR-452-3p inhibited osteoblast differentiation by targeting Smad4 [PDF]

PeerJ, 2021
Osteoblast differentiation is a complex process that is essential for normal bone formation. A growing number of studies have shown that microRNAs (miRNAs) are key regulators in a variety of physiological and pathological processes, including ...
Ming Wu, Hongyan Wang, Dece Kong, Jin Shao, Chao Song, Tieyi Yang, Yan Zhang   +6 more
doaj   +2 more sources

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]

, 2017
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe   +3 more
core   +9 more sources

SLC38A2 provides proline and alanine to regulate postnatal bone mass accrual in mice

Frontiers in Physiology, 2022
Amino acids have recently emerged as important regulators of osteoblast differentiation and bone formation. Osteoblasts require a continuous supply of amino acids to sustain biomass production to fuel cell proliferation, osteoblast differentiation and ...
Leyao Shen, Yilin Yu, Courtney M. Karner, Courtney M. Karner, Courtney M. Karner   +4 more
doaj   +1 more source

Constitutive activation of Gli2 impairs bone formation in postnatal growing mice. [PDF]

PLoS ONE, 2013
Indian hedgehog (Ihh) signaling is indispensable for osteoblast differentiation during endochondral bone development in the mouse embryo.
Kyu Sang Joeng, Fanxin Long
doaj   +1 more source

Probiotic Propionibacterium freudenreichii MJ2 Enhances Osteoblast Differentiation and Mineralization by Increasing the OPG/RANKL Ratio

Microorganisms, 2021
Osteoblast differentiation is important for the development of bone and the maintenance of bone density. Propionibacterium freudenreichii is a probiotic with an anti-inflammatory property.
Jiah Yeom, Seongho Ma, Young-Hee Lim
doaj   +1 more source

BMP-2 Induced Expression of Alx3 That Is a Positive Regulator of Osteoblast Differentiation. [PDF]

PLoS ONE, 2013
Bone morphogenetic proteins (BMPs) regulate many aspects of skeletal development, including osteoblast and chondrocyte differentiation, cartilage and bone formation, and cranial and limb development.
Takashi Matsumoto, Atsushi Yamada, Ryo Aizawa, Dai Suzuki, Masayuki Tsukasaki, Wataru Suzuki, Mutsuko Nakayama, Koutaro Maki, Matsuo Yamamoto, Kazuyoshi Baba, Ryutaro Kamijo   +10 more
doaj   +1 more source

Core-binding factor beta is required for osteoblast differentiation during fibula fracture healing

Journal of Orthopaedic Surgery and Research, 2021
Background Growing evidence has implicated core-binding factor beta (Cbfb) as a contributor to osteoblast differentiation, which plays a key role in fracture healing. Herein, we aimed to assess whether Cbfb affects osteoblast differentiation after fibula
Tuanmao Guo, Yanli Xing, Zhongning Chen, Xianhong Wang, Haiyun Zhu, Lan Yang, Yong Yan   +6 more
doaj   +1 more source

Cell Transitions Contribute to Glucocorticoid-Induced Bone Loss

Cells, 2023
Glucocorticoid-induced bone loss is a toxic effect of long-term therapy with glucocorticoids resulting in a significant increase in the risk of fracture.
Xiaojing Qiao, Xiuju Wu, Yan Zhao, Yang Yang, Li Zhang, Xinjiang Cai, Jocelyn A. Ma, Jaden Ji, Karen Lyons, Kristina I. Boström, Yucheng Yao   +10 more
doaj   +1 more source