Osteocytes as a record of bone formation dynamics: A mathematical model of osteocyte generation in bone matrix [PDF]
J Theor Biol 364: 418-427 (2015), 2014 The formation of new bone involves both the deposition of bone matrix, and the formation of a network of cells embedded within the bone matrix, called osteocytes. Osteocytes derive from bone-synthesising cells (osteoblasts) that become buried in bone matrix during bone deposition.
Buenzli, Pascal R
arxiv +6 more sources
The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model [PDF]
, 2013 Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This
Ayati, Bruce P. +3 more
core +23 more sources
miR-452-3p inhibited osteoblast differentiation by targeting Smad4 [PDF]
PeerJ, 2021 Osteoblast differentiation is a complex process that is essential for normal bone formation. A growing number of studies have shown that microRNAs (miRNAs) are key regulators in a variety of physiological and pathological processes, including ...
Ming Wu +6 more
doaj +2 more sources
SLC38A2 provides proline and alanine to regulate postnatal bone mass accrual in mice
Frontiers in Physiology, 2022 Amino acids have recently emerged as important regulators of osteoblast differentiation and bone formation. Osteoblasts require a continuous supply of amino acids to sustain biomass production to fuel cell proliferation, osteoblast differentiation and ...
Leyao Shen +4 more
doaj +1 more source
Microorganisms, 2021 Osteoblast differentiation is important for the development of bone and the maintenance of bone density. Propionibacterium freudenreichii is a probiotic with an anti-inflammatory property.
Jiah Yeom, Seongho Ma, Young-Hee Lim
doaj +1 more source
Controlled oxygen plasma treatment of single-walled carbon nanotube films improves osteoblast cells attachment and enhances their proliferation [PDF]
Carbon, 49, 2926-2934 (2011), 2021 The effects of oxidative treatment of single-walled carbon nanotubes (SWCNTs) on the adhesion and proliferation of human osteoblasts (SAOS-2) were investigated. The surface properties of SWCNTs after oxygen plasma treatment were characterised by contact angle measurement, scanning electron microscopy and Raman spectroscopy.
arxiv +1 more source
Constitutive activation of Gli2 impairs bone formation in postnatal growing mice. [PDF]
PLoS ONE, 2013 Indian hedgehog (Ihh) signaling is indispensable for osteoblast differentiation during endochondral bone development in the mouse embryo.
Kyu Sang Joeng, Fanxin Long
doaj +1 more source
Tunable PEG Hydrogels for Discerning Differential Tumor Cell Response to Biomechanical Cues
Advanced Biology, Volume 6, Issue 12, December 2022., 2022 The stiffness and adhesivity of poly(ethylene glycol) hydrogels influence the behavior of tumor cells cultured within or on top of these hydrogels. A triple negative breast cancer cell line is shown to primarily respond to the adhesion ligand concentration while a fibrosarcoma cell line is shown to primarily respond to the stiffness of these hydrogels.
Rachel R. Katz, Jennifer L. West
wiley +1 more source
Incorporation and effects of mesoporous SiO2-CaO nanospheres loaded with ipriflavone on osteoblast/osteoclast cocultures [PDF]
Eur. J. Pharm. Biopharm. 133, 258-268 (2018), 2021 Mesoporous nanospheres in the system SiO2-CaO (NanoMBGs) with a hollow core surrounded by a radial arrangement of mesopores were characterized, labeled with FITC (FITC-NanoMBGs) and loaded with ipriflavone (NanoMBG-IPs) in order to evaluate their incorporation and their effects on both osteoblasts and osteoclasts simultaneously and maintaining the ...
arxiv +1 more source
Quantification of cell contractile behavior based on non-destructive macroscopic measurement of tension forces on bioprinted hydrogel [PDF]
Journal of the mechanical behavior of biomedical materials, 2022,
134, pp.105365, 2023 Contraction assay based on surface measurement have been widely used to evaluate cell contractility in 3D models. This method is straightforward and requires no specific equipment, but it does not provide quantitative data about contraction forces generated by cells.
arxiv +1 more source