Results 91 to 100 of about 38,017 (252)

Maternal Exercise Rescues Embryonic Osteogenesis Impaired due to POLG Mutation Through a Potential Apelin‐ATF4 Axis

Advanced Science, EarlyView.
Maternal exercise (ME) increases apelin abundance across maternal and fetal tissues and is associated with improved fetal osteogenesis under POLG mutation‐induced mitochondrial dysfunction. Apelin‐APJ signaling is linked to enhanced mitochondrial function, Akt phosphorylation, and ATF4‐RUNX2 association, supporting coordinated fetal bone remodeling ...
Song Ah Chae, Ryan C. Riddle, Zhihua Jiang, Chaeyoung Shin, Min Du, Jun Seok Son   +5 more
wiley   +1 more source

Cell therapy in bone healing disorders

Orthopedic Reviews, 2010
In addition to osteosynthetic stabilizing techniques and autologous bone transplantations, so-called orthobiologics play an increasing role in the treatment of bone healing disorders.
Marcus Jäger, Philippe Hernigou, Christoph Zilkens, Monika Herten, Xinning Li, Johannes Fischer, Rüdiger Krauspe   +6 more
doaj   +1 more source

Dysregulation of the MACF1‐Rab14/KIF16B‐FGFR Vesicular Trafficking Axis Skews MSC Lineage Commitment in Glucocorticoid‐Induced Osteoporosis

Advanced Science, EarlyView.
Under normal conditions, MACF1 interacts with Rab14 and facilitates KIF16B‐mediated FGFR vesicle trafficking along microtubules to the plasma membrane, thereby supporting BMSC differentiation. In contrast, chronic GC exposure suppresses MACF1 expression, disrupting this transport and causing intracellular FGFR retention, which blunts osteogenic ...
Peihong Su, Ye Tian, Fan Zhao, Jing Li, Suryaji Patil, Chunyu Zhu, Yujia Tian, Junrong Wang, Jiating Liu, Aoqi Xiang, Hua Guan, Lusha Zhang, Xiaochang Chen, Airong Qian, Qi Yu   +14 more
wiley   +1 more source

Pannexin 3-mediated adenosine triphosphate release from pre-osteoblasts promotes osteoblast differentiation through P2X4 receptor activation

Frontiers in Physiology
Increased pre-osteoblast cell density within bone resorption areas is a key factor in promoting osteoblast differentiation; however, the molecular mechanisms underlying this process remain poorly understood. In this study, we investigated the role of ATP
Hiroaki Kito, Ayano Niwa, Takusei Ryu, Yohei Yamaguchi, Junko Kajikuri, Susumu Ohya   +5 more
doaj   +1 more source

Bacteria Death and Osteoblast Metabolic Activity Correlated to Hydrothermally Synthesised TiO₂ Surface Properties [PDF]

, 2019
Orthopaedic surgery comes with an inherent risk of bacterial infection, prolonged antibiotic therapy and revision surgery. Recent research has focused on nanostructured surfaces to improve the bactericidal and osseointegrational properties of implants ...
Tuquabo Tesfamichael, Wang, Hongxia, Asha Mathew, Mathew, Asha, Alka Jaggessar, Tesfamichael, Tuquabo, Prasad KDV Yarlagadda, Cheng Yan, Hongxia Wang, Prasad KDV Yarlagadda, Yarlagadda, Prasad KDV, Jaggessar, Alka, Yan, Cheng   +12 more
core   +1 more source

Machine Learning‐Driven Design of Multicomponent Bone Inorganic Matrix Mimicking Scaffolds for Osteogenesis Enhanced by Neurogenesis

Advanced Science, EarlyView.
Schematic illustration of development of experimental datasets and algorithm models, screening and preparation of the scaffolds and their applications in vivo. ABSTRACT Bone defects require materials with osteogenic, neurogenic, and angiogenic activity, yet designing such materials within high‐dimensional compositional spaces remains challenging. Here,
Kunlu Lin, Ying Yang, Chuyao Zhou, Hanyue Mao, Zhiquan Zhang, Libangxi Liu, Xiaoying Yu, Haoming Liu, Long Liu, Xiaoyan Wang   +9 more
wiley   +1 more source

On a Class of Bone Cell-Based Remodeling Laws with Spatial Fading Influence of Stimuli

Engineering Transactions, 2015
In the present paper the class of cell-based bone remodeling laws is considered. The fundamental assumption is that of fading in space influence on actor cells osteocytes functioning as sensors.
T. Lekszycki
doaj   +1 more source

Recovering Osteoblast Functionality on TiO2 Nanotube Surfaces Under Diabetic Conditions

, 2022
Benjamin Valdez-Salas,1 Sandra Castillo-Uribe,1 Ernesto Beltran-Partida,1 Mario Curiel-Alvarez,1 Oscar Perez-Landeros,1 Minerva Guerra-Balcazar,2 Nelson Cheng,3 Daniel Gonzalez-Mendoza,4 Olivia Flores-Peñaloza1 1Laboratorio de Biología Molecular y Cáncer,
Perez-Landeros O, Flores-Peñaloza O, Guerra-Balcazar M, Valdez-Salas B, Gonzalez-Mendoza D, Curiel-Alvarez M, Cheng N, Beltran-Partida E, Castillo-Uribe S   +8 more
core  

Regulating Cells Fate and Function to Facilitate Bone Regeneration via Designing Programmable Bio‐Interactive Materials

Advanced Science, EarlyView.
This article aims to elucidate the biological mechanisms of bone repair and the evolution of material design, highlighting key cellular and molecular processes. It further proposes strategies and prospects for programmable bio‐interactive materials, which enable precisely guided bone tissue regeneration by dynamically regulating cell behavior and the ...
Qingrui Fan, Fuming Cao, Junqiang Mao, Pengbin Yin, Licheng Zhang, Jianjun Wang, Peifu Tang   +6 more
wiley   +1 more source

Electronic Chip‐Mimetic Medical Implants for Controllable Sonothermal Treatments

Advanced Science, EarlyView.
Inspired by the thermal effect of working electronic chips, which consist of various heterostructures, an sonothermal‐responsive platform has been developed through constructing metal‐semiconductor interface on implants. Biofilm infection and deep vein thrombosis can be successfully treated by controllable ultrasound treatments.
Zhengdong Zhang, Pan Liu, Jie Lei, Shuchang Peng, Qiu Chen, Wei Guan, Yizhou Zhu, Gang Liu, Xiaobo Feng, Cao Yang, Lei Tan   +10 more
wiley   +1 more source