Results 11 to 20 of about 87,991 (243)

Resveratrol Attenuates High Glucose-Induced Osteoblast Dysfunction via AKT/GSK3β/FYN-Mediated NRF2 Activation

Frontiers in Pharmacology, 2022
Osteoblast dysfunction, induced by high glucose (HG), negatively impacts bone homeostasis and contributes to the pathology of diabetic osteoporosis (DOP).
Yue Xuan, Jie Wang, Xiaohui Zhang, Jie Wang, Jiahao Li, Qingbo Liu, Guangping Lu, Mengjie Xiao, Ting Gao, Yuanfang Guo, Cong Cao, Ou Chen, Kunli Wang, Yufeng Tang, Junlian Gu   +14 more
doaj   +1 more source

PPAR Gamma Activity and Control of Bone Mass in Skeletal Unloading

PPAR Research, 2006
Bone loss occuring with unloading is associated with decreased osteoblastogenesis and increased bone marrow adipogenesis, resulting in bone loss and decreased bone formation.
P. J. Marie, K. Kaabeche
doaj   +1 more source

Repression of osteoblast maturation by ERRα accounts for bone loss induced by estrogen deficiency. [PDF]

PLoS ONE, 2013
ERRα is an orphan member of the nuclear receptor family, the complete inactivation of which confers resistance to bone loss induced by ageing and estrogen withdrawal to female mice in correlation with increased bone formation in vivo.
Marlène Gallet, Soraya Saïdi, Eric Haÿ, Johann Photsavang, Caroline Marty, Juliette Sailland, Julie Carnesecchi, Violaine Tribollet, Bruno Barenton, Christelle Forcet, Marie-Christine Birling, Tania Sorg, Olivier Chassande, Martine Cohen-Solal, Jean-Marc Vanacker   +14 more
doaj   +1 more source

Hedgehog signaling regulates osteoblast differentiation in zebrafish larvae through modulation of autophagy

Biology Open, 2019
Impaired osteoblast differentiation may result in bone metabolic diseases such as osteoporosis. It was reported recently that hedgehog (Hh) signaling and autophagy are two important regulators of bone differentiation.
Zhanying Hu, Bo Chen, Qiong Zhao
doaj   +1 more source

MAF1, a repressor of RNA polymerase III-dependent transcription, regulates bone mass

eLife, 2022
MAF1, a key repressor of RNA polymerase (pol) III-mediated transcription, has been shown to promote mesoderm formation in vitro. Here, we show that MAF1 plays a critical role in regulating osteoblast differentiation and bone mass. Global deletion of MAF1
Ellen Phillips, Naseer Ahmad, Li Sun, James Iben, Christopher J Walkey, Aleksandra Rusin, Tony Yuen, Clifford J Rosen, Ian M Willis, Mone Zaidi, Deborah L Johnson   +10 more
doaj   +1 more source

Transcriptional regulation of bone formation by the osteoblast-specific transcription factor Osx

Journal of Orthopaedic Surgery and Research, 2010
Bone formation is a complex developmental process involving the differentiation of mesenchymal stem cells to osteoblasts. Osteoblast differentiation occurs through a multi-step molecular pathway regulated by different transcription factors and signaling ...
Zhang Chi
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The influence of periostin on osteoblastic adhesion and proliferation on collagen matrices - An in vitro study

Journal of Indian Society of Periodontology, 2021
Purpose: The purpose of the study was to evaluate the ability of periostin when impregnated onto varied collagen matrices to influence osteoblast cell adhesion, proliferation, and activity. Materials and Methods: Saos-2 osteoblast cells were cultured and
Suganthi Mohanarangam, Dhayanand John Victor, Sangeetha Subramanian, P SG Prakash   +3 more
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Primary human osteoblasts in response to 25-hydroxyvitamin D3, 1,25-dihydroxyvitamin D3 and 24R,25-dihydroxyvitamin D3. [PDF]

PLoS ONE, 2014
The most biologically active metabolite 1,25-dihydroxyvitamin D3 (1,25(OH)2D3) has well known direct effects on osteoblast growth and differentiation in vitro. The precursor 25-hydroxyvitamin D3 (25(OH)D3) can affect osteoblast function via conversion to
Karen van der Meijden, Paul Lips, Marjolein van Driel, Annemieke C Heijboer, Engelbert A J M Schulten, Martin den Heijer, Nathalie Bravenboer   +6 more
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The Effects of Receptor Activator of NF-κB Ligand-Binding Peptides on Bone Resorption and Bone Formation

Frontiers in Cell and Developmental Biology, 2021
Receptor activator of NF-κB ligand (RANKL)-binding peptides inhibit bone resorption and were recently shown to activate bone formation. The stimulatory mechanism underlying bone formation associated with these peptides was explained as RANKL-reverse ...
Fatma Rashed, Fatma Rashed, Shingo Kamijyo, Yuri Shimizu, Yuna Hirohashi, Masud Khan, Yasutaka Sugamori, Ramachandran Murali, Kazuhiro Aoki   +8 more
doaj   +1 more source

Effects of Modulation of the Hedgehog and Notch Signaling Pathways on Osteoblast Differentiation Induced by Titanium with Nanotopography

Journal of Functional Biomaterials, 2023
Background: The events of bone formation and osteoblast/titanium (Ti) interactions may be affected by Hedgehog and Notch signalling pathways. Herein, we investigated the effects of modulation of these signalling pathways on osteoblast differentiation ...
Paola Gomes Souza, Leticia Faustino Adolpho, Helena Bacha Lopes, Denise Weffort, Alann Thaffarell Portilho Souza, Fabiola Singaretti Oliveira, Adalberto Luiz Rosa, Marcio Mateus Beloti   +7 more
doaj   +1 more source