Results 41 to 50 of about 2,079,758 (368)

RAGE Signaling in Skeletal Biology [PDF]

, 2019
PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M., Essex, Alyson L., Plotkin, Lilian I.   +2 more
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SLC38A2 provides proline to fulfill unique synthetic demands arising during osteoblast differentiation and bone formation

eLife, 2022
Cellular differentiation is associated with the acquisition of a unique protein signature that is essential to attain the ultimate cellular function and activity of the differentiated cell.
Leyao Shen, Yilin Yu, Yunji Zhou, Shondra M Pruett-Miller, Guo-Fang Zhang, Courtney M Karner   +5 more
doaj   +1 more source

The Synergistic Regulatory Effect of Runx2 and MEF Transcription Factors on Osteoblast Differentiation Markers [PDF]

, 2010
Purpose: Bone tissues for clinical application can be improved by studies on osteoblast differentiation. Runx2 is known to be an important transcription factor for osteoblast differentiation.
Cho, Je-Yoel, Lee, Jae-Mok, Libermann, Towia Aron   +2 more
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FOXO1 modulates osteoblast differentiation

Bone, 2011
Forkhead box O1 (FOXO1) is upregulated during bone formation and in response to stimulation by bone morphogenetic proteins. Studies presented here examined the functional role of FOXO1 in a well defined culture system in which pre-osteoblastic cells undergo terminal differentiation in vitro. Mineralizing cultures of MC3T3-E1 cells were examined with or
Siqueira, Michelle F, Flowers, Stephen, Bhattacharya, Rupa, Faibish, Dan, Behl, Yugal, Kotton, Darrell N, Gerstenfeld, Lou, Moran, Elizabeth, Graves, Dana T   +8 more
openaire   +4 more sources

SNHG14 induces osteogenic differentiation of human stromal (mesenchymal) stem cells in vitro by downregulating miR-2861

BMC Musculoskeletal Disorders, 2020
Background The differentiation of human stromal (mesenchymal) stem cells (hMSCs) is a critical procedure for the development of osteoblast. SNHG14 is a newly discovered lncRNA that has been barely studied.
Mingchang Du, Bo Wu, Shiwen Fan, Ye Liu, Xu Ma, Xun Fu   +5 more
doaj   +1 more source

Suppression of autophagy by FIP200 deletion leads to osteopenia in mice through the inhibition of osteoblast terminal differentiation [PDF]

, 2013
Autophagy is a conserved lysosomal degradation process that has important roles in both normal human physiology and disease. However, the function of autophagy in bone homeostasis is not well understood. Here, we report that autophagy is activated during
Abbi, Bae, Baerga, Buckbinder, Cecconi, Chandhoke, DeSelm, Feldkamp, Fimia, Gan, Gan, Ganley, Gomes, Hara, Hara, Hara, Hocking, Hosokawa, Hubbard, Jia, Jung, Kim, Komatsu, Komatsu, Komatsu, Kuhn, Kuma, Levine, Liang, Liu, Liu, Liu, Manolagas, McCreadie, McLeod, Meganck, Mijaljica, Miller, Mizushima, Mizushima, Mizushima, Mizushima, Mizushima, Mortensen, Mortensen, Narita, Pan, Parfitt, Pua, Pua, Rabinowitz, Rodda, Sandoval, Shoji-Kawata, Singh, Slack-Davis, Spilman, Srinivas, Stephenson, Stokes, Tsukamoto, Ueda, Volkman, Volkman, Wang, Wei, Whitehouse, Wullschleger, Xia, Yang, Yue, Zahm, Zhang, Zhang, Zhang   +74 more
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Evaluation of odonto/osteogenic differentiation potential from different regions derived dental tissue stem cells and effect of 17β-estradiol on efficiency

BMC Oral Health, 2021
Background The dentin is a tissue, which is formed by odontoblasts at the pulp interface of the teeth that supports the enamel. Odontoblasts, the cranial neural crest cells are derived from ectodermal mesenchymal stem cells (MSCs) and are long and ...
Young-Bum Son, Young-Hoon Kang, Hyeon-Jeong Lee, Si-Jung Jang, Dinesh Bharti, Sung-Lim Lee, Byeong-Gyun Jeon, Bong-Wook Park, Gyu-Jin Rho   +8 more
doaj   +1 more source

Proteomic Analysis of Human Osteoblastic Cells: Relevant Proteins and Functional Categories for Differentiation [PDF]

, 2010
Osteoblasts are the bone forming cells, capable of secreting an extracellular matrix with mineralization potential. The exact mechanism by which osteoblasts differentiate and form a mineralized extracellular matrix is presently not fully understood.
Alves, R.D.A.M. (Rodrigo), Burgers, P.C. (Peter), Chiba, H. (Hideki), Eijken, H.J.M. (Marco), Leeuwen, J.P.T.M. (Hans) van, Luider, T.M. (Theo), Swagemakers, S.M.A. (Sigrid), Titulaer, M.K. (Mark)   +7 more
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MiR-33a Controls hMSCS Osteoblast Commitment Modulating the Yap/Taz Expression Through EGFR Signaling Regulation [PDF]

, 2019
Mesenchymal stromal cells (hMSCs) display a pleiotropic function in bone regeneration. The signaling involved in osteoblast commitment is still not completely understood, and that determines the failure of current therapies being used.
Alessandro, Riccardo, Bellavia, Daniele, Carina, Valeria, Conigliaro, Alice, Costa, Viviana, De Luca, Angela, Fini, Milena, Giavaresi, Gianluca, Raimondi, Lavinia, Salamanna, Francesca   +9 more
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Gastric carcinoma with osteoblastic differentiation

International Journal of Surgery Case Reports, 2012
Carcinosarcoma is a rare malignant biphasic tumor which has sarcomatous and carcinomatous components. Stomach localization is very rare. We discuss the diagnosis, follow-up and treatment of patients diagnosed with gastric carcinosarcoma in company with the literature review.A 73-year-old white male patient applied to hospital with dyspeptic complaints ...
Selcukbiricik, Fatih, Tural, Deniz, Senel, Elif Tuba, Dervisoglu, Sergülen, Serdengecti, Süheyla   +4 more
openaire   +2 more sources