The molecular signature of the stroma response in prostate cancer-induced osteoblastic bone metastasis highlights expansion of hematopoietic and prostate epithelial stem cell niches. [PDF]
PLoS ONE, 2014 The reciprocal interaction between cancer cells and the tissue-specific stroma is critical for primary and metastatic tumor growth progression. Prostate cancer cells colonize preferentially bone (osteotropism), where they alter the physiological balance ...
Berna C Özdemir +13 more
doaj +7 more sources
Osteoblastic metastasis from signet ring cell gastric cancer in a young male [PDF]
The Turkish Journal of Gastroenterology, 2014 Bone metastasis is common in patients with lung, prostate, and breast cancers but it isn’t common in stomach cancer. Gastric carcinoma infrequently metastasizes to the bone and rarely in an osteoblastic form.
Fatih Ermiş +5 more
doaj +2 more sources
The host microenvironment influences prostate cancer invasion, systemic spread, bone colonization, and osteoblastic metastasis [PDF]
Frontiers in Oncology, 2014 Prostate cancer (PCa) is the second leading cause of cancer death in men worldwide. Most PCa patients die with osteoblastic bone metastases. What triggers PCa metastasis to the bone and what causes osteoblastic lesions remain unanswered.
Sourik S Ganguly +2 more
doaj +2 more sources
Influence of the Different Primary Cancers and Different Types of Bone Metastasis on the Lesion-based Artificial Neural Network Value Calculated by a Computer-aided Diagnostic System,BONENAVI, on Bone Scintigraphy Images [PDF]
Asia Oceania Journal of Nuclear Medicine and Biology, 2017 Objective(s): BONENAVI, a computer-aided diagnostic system, is used in bone scintigraphy. This system provides the artificial neural network (ANN) and bone scan index (BSI) values.
TAKURO ISODA +7 more
doaj +2 more sources
A case of lung cancer with osteoblastic metastasis diagnosed with visual impairment
Interdisciplinary Neurosurgery, 2021 Bone metastasis is relatively common in patients with lung cancers. Although there are some reports of osteolytic skull base metastasis in lung cancer, osteoblastic skull base metastasis is quite rare.
Hiroki Sato +3 more
doaj +2 more sources
Pathogenesis of bone metastasis
Journal of Oncological Sciences, 2016 Bone metastases are more frequently seen as a complication of cancer than primary bone tumors. For example, it can be seen in as many as 70% of advanced stage breast and prostate cancer cases.
Erdinc Nayir
doaj +2 more sources
DKK1 and Kremen Expression Predicts the Osteoblastic Response to Bone Metastasis
Translational Oncology, 2018 Bone metastasis is a complication of advanced breast and prostate cancer. Tumor-secreted Dickkopf homolog 1 (DKK1), an inhibitor of canonical Wnt signaling and osteoblast differentiation, was proposed to regulate the osteoblastic response to metastatic ...
Katrina L. Clines, Gregory A. Clines
doaj +2 more sources
Targeting bone remodeling by isoflavone and 3,3'-diindolylmethane in the context of prostate cancer bone metastasis. [PDF]
PLoS ONE, 2012 Prostate cancer (PCa) bone metastases have long been believed to be osteoblastic because of bone remodeling leading to the formation of new bone. However, recent studies have shown increased osteolytic activity in the beginning stages of PCa bone ...
Yiwei Li +4 more
doaj +2 more sources
The negative prognostic impact of bone metastasis with a tumor mass
Clinics, 2015 OBJECTIVE:Typically, bone metastasis causes osteolytic and osteoblastic lesions resulting from the interactions of tumor cells with osteoclasts and osteoblasts. In addition to these interactions, tumor tissues may grow inside bones and cause mass lesions.
Birsen Yücel +7 more
doaj +2 more sources
GDF15 promotes prostate cancer bone metastasis and colonization through osteoblastic CCL2 and RANKL activation [PDF]
Bone Research, 2022 Bone metastases occur in patients with advanced-stage prostate cancer (PCa). The cell-cell interaction between PCa and the bone microenvironment forms a vicious cycle that modulates the bone microenvironment, increases bone deformities, and drives tumor ...
Jawed Akhtar Siddiqui +12 more
doaj +2 more sources