Results 21 to 30 of about 1,211,688 (156)

Molecular mechanism of bone metastasis in breast cancer [PDF]

Frontiers in Oncology
Bone metastasis is a debilitating complication that frequently occurs in the advanced stages of breast cancer. However, the underlying molecular and cellular mechanisms of the bone metastasis remain unclear.
Laijian Sui, Laijian Sui, Jing Wang, Wen G. Jiang, Xicheng Song, Lin Ye   +5 more
doaj   +2 more sources

Prostate adenocarcinoma presenting as diffuse osteolytic metastasis

Clinical Case Reports, 2022
Prostate cancer is one of the most common cancers that metastasize to the bone. Bone metastasis is usually osteoblastic, and diffuse osteolytic lesion on presentation is unusual.
Mohanad Faisal, Abdulrahman F. Al‐Mashdali, Noor Jasim, Mohamed Salem Ismail Khalil   +3 more
doaj   +2 more sources

Restoring Tissue Homeostasis at Metastatic Sites: A Focus on Extracellular Vesicles in Bone Metastasis [PDF]

Frontiers in Oncology, 2021
Bone is the most common site of cancer metastasis and the spread of cancer cells to the bone is associated with poor prognosis, pain, increased risk of fractures, and hypercalcemia.
Domenica Giannandrea, Valentina Citro, Elena Lesma, Monica Bignotto, Natalia Platonova, Raffaella Chiaramonte   +5 more
doaj   +2 more sources

A novel patient-derived intra-femoral xenograft model of bone metastatic prostate cancer that recapitulates mixed osteolytic and osteoblastic lesions [PDF]

Journal of Translational Medicine, 2011
Prostate cancer metastasizes to bone in the majority of patients with advanced disease leading to painfully debilitating fractures, spinal compression and rapid decline.
Raheem Omer, Kulidjian Anna A, Wu Christina, Jeong Young B, Yamaguchi Tomonori, Smith Kristen M, Goff Daniel, Leu Heather, Morris Sheldon R, Cacalano Nicholas A, Masuda Koichi, Jamieson Catriona HM, Kane Christopher J, Jamieson Christina AM   +13 more
doaj   +2 more sources

Review of Animal Models of Prostate Cancer Bone Metastasis

Veterinary Sciences, 2014
Prostate cancer bone metastases are associated with a poor prognosis and are considered incurable. Insight into the formation and growth of prostate cancer bone metastasis is required for development of new imaging and therapeutic strategies to combat ...
Jessica K. Simmons, Said M. Elshafae, Evan T. Keller, Laurie K. McCauley, Thomas J. Rosol   +4 more
doaj   +2 more sources

Correlation of the Levels of the Bone Turnover Markers BAP and β-CTX with Bone Metastasis Progress in Lung Cancer Patients

Chinese Journal of Lung Cancer, 2013
Background and objective Bone metastasis is common in lung cancer patients. The β isomer of the C-terminal telopeptide of type I collagen (β-CTX) and bone-specific alkaline phosphates (BAP) are regarded as important bone turnover markers in bone ...
Qiong TANG, Hui ZHAO, Rui JIA, Linlin LIU   +3 more
doaj   +2 more sources

AIF1+CSF1R+ MSCs, induced by TNF‐α, act to generate an inflammatory microenvironment and promote hepatocarcinogenesis

Hepatology, EarlyView., 2022
Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong, Yan Meng, Fei Ye, Xue Yang, Rong Li, Jinghua Jiang, Qiudong Zhao, Lu Gao, Zhipeng Han, Lixin Wei   +9 more
wiley   +1 more source

Accurate Monitoring of the Response of Bone Metastases to Treatment in Patients with Prostate Cancer Using Choline PET/CT

Case Reports in Oncology, 2021
We here report 2 cases of castration-resistant prostate cancer (CRPC) observed two times on 11C-choline positron emission tomography computed tomography (PET/CT), which was useful to discriminate viable progressive osteoblastic bone metastasis from ...
Kazuhiro Kitajima, Shingo Yamamoto, Masayuki Fujiwara, Yusuke Kawanaka, Yusuke Yamada, Seiji Nagasawa, Kimihiro Shimatani, Takeshi Hanasaki, Motohiro Taguchi, Akihiro Kanematsu, Koichiro Yamakado   +10 more
doaj   +1 more source

Osteoblast‐derived extracellular vesicles exert osteoblastic and tumor‐suppressive functions via SERPINA3 and LCN2 in prostate cancer

Molecular Oncology, 2023
Clinically, the osteolytic phenotype is rare in prostate cancer (PCa), and the prognosis is generally worse than that of the osteoblastic phenotype. Osteoblastic prostate cancer (BPCa) is a major type of bone metastasis.
Kagenori Ito, Tomofumi Yamamoto, Yusuke Hayashi, Shun Sato, Jun Nakayama, Fumihiko Urabe, Takeo Shimasaki, Eijiro Nakamura, Yoshiyuki Matui, Hiroyuki Fujimoto, Takahiro Kimura, Shin Egawa, Takahiro Ochiya, Yusuke Yamamoto   +13 more
doaj   +1 more source

The link between bone-derived factors osteocalcin, fibroblast growth factor 23, sclerostin, lipocalin 2 and tumor bone metastasis

Frontiers in Endocrinology, 2023
The skeleton is the third most common site of metastatic disease, which causes serious bone complications and short-term prognosis in cancer patients.
Monika Martiniakova, Vladimira Mondockova, Roman Biro, Veronika Kovacova, Martina Babikova, Nina Zemanova, Sona Ciernikova, Radoslav Omelka   +7 more
doaj   +1 more source