Results 31 to 40 of about 18,733 (222)

Exosomes derived from osteogenic tumor activate osteoclast differentiation and concurrently inhibit osteogenesis by transferring COL1A1‐targeting miRNA‐92a‐1‐5p

Journal of Extracellular Vesicles, 2021
In patients with prostate cancer (PCa), bone lesions appear osteoblastic in radiographs; however, pathological fractures frequently occur in PCa patients, and bone resorption is observed in all metastatic lesions under histopathologic assessment.
Lijuan Yu, Bingdong Sui, Weixiao Fan, Lin Lei, Lei Zhou, Liu Yang, Yanjun Diao, Yue Zhang, Zhuo Li, Jiayun Liu, Xiaoke Hao   +10 more
doaj   +1 more source

Research Progress of Tumor Microenvironment and Prostate Cancer Bone Metastasis

Zhongliu Fangzhi Yanjiu, 2018
The majority of prostate cancer (PCa)-induced deaths is due to the development of metastatic disease, 80% of which is primarily localized in the bone. The types of bone metastasis of PCa are mainly osteoblastic or osteoclastic lesions.
MENG Jie, LU Yi, ZHANG Jian
doaj   +1 more source

MicroRNA-466 inhibits tumor growth and bone metastasis in prostate cancer by direct regulation of osteogenic transcription factor RUNX2. [PDF]

, 2017
MicroRNAs (miRNAs) have emerged as key players in cancer progression and metastatic initiation yet their importance in regulating prostate cancer (PCa) metastasis to bone has begun to be appreciated.
Colden, Melissa, Dahiya, Priya V, Dahiya, Rajvir, Dar, Altaf A, Majid, Shahana, Saini, Sharanjot, Shahryari, Varahram, Stein, Gary, Tanaka, Yuichiro, Yamamura, Soichiro   +9 more
core   +2 more sources

Procoxacin bidirectionally inhibits osteoblastic and osteoclastic activity in bone and suppresses bone metastasis of prostate cancer

Journal of Experimental & Clinical Cancer Research, 2023
Abstract Background Bone is the most common site of metastasis of prostate cancer (PCa). PCa invasion leads to a disruption of osteogenic-osteolytic balance and causes abnormal bone formation. The interaction between PCa and bone stromal cells, especially osteoblasts (OB), is considered essential for the disease ...
Depei Kong, Chen Ye, Chenxi Zhang, Xiaochen Sun, Fubo Wang, Rui Chen, Guangan Xiao, Shipeng He, Jianrong Xu, Xiwu Rao, Jianzhong Ai, Xu Gao, Hong Li, Li Su   +13 more
openaire   +3 more sources

Pseudoprogression after advanced first-line endocrine therapy in metastatic breast cancer with bone metastasis: A case report

Frontiers in Oncology, 2023
Approximately 75% of patients with advanced breast cancer develop bone metastasis, which significantly affects both the quality of life and the survival rate of patients. Accurate determination of the status of bone metastases is important for developing
Aijuan Tian, Huiyun Lv, Wei Liu, Jinbo Zhao, Shanshan Zhao, Kainan Wang, Chen Song   +6 more
doaj   +1 more source

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces [PDF]

, 2015
The diverse composition and structure of extracellular matrix (ECM) interfaces encountered by tumor cells at secondary tissue sites can influence metastatic progression. Extensive in vitro and in vivo data has confirmed that metastasizing tumor cells can
Caley, Matthew P., Gronau, Julian H., King, Helen, Rodriguez-Teja, Mercedes, Shah, Neel, Sturge, Justin, Wang, Kai, Waxman, Jonathan   +7 more
core   +2 more sources

Regulation of bone homeostasis by MERTK and TYRO3

Nature Communications, 2022
The TAM family of receptor tyrosine kinases exerts pleiotropic functions in health and disease. Here, the authors show that TAM receptors control osteoblastic bone formation and identified MERTK as a novel target for bone anabolic therapy and mitigation ...
Janik Engelmann, Jennifer Zarrer, Victoria Gensch, Kristoffer Riecken, Nikolaus Berenbrok, The Vinh Luu, Antonia Beitzen-Heineke, Maria Elena Vargas-Delgado, Klaus Pantel, Carsten Bokemeyer, Somasekhar Bhamidipati, Ihab S. Darwish, Esteban Masuda, Tal Burstyn-Cohen, Emily J. Alberto, Sourav Ghosh, Carla Rothlin, Eric Hesse, Hanna Taipaleenmäki, Isabel Ben-Batalla, Sonja Loges   +20 more
doaj   +1 more source

Role of key players in paradigm shifts of prostate cancer bone metastasis [PDF]

, 2018
Prostate cancer is one of the most common human cancers and bone metastasis is a frequent finding in the natural history of several types of cancers. The molecular mechanisms that makes prostate cancer metastasize to bone have recently been identified, and
Beg, OA, Butt, SI, Iqbal, S, Javed, S, Li, Z, Sherin, L, Sohail, A   +6 more
core   +2 more sources

Osteoblasts and osteoclasts: an important switch of tumour cell dormancy during bone metastasis

Journal of Experimental & Clinical Cancer Research, 2022
AbstractBone metastasis occurs when tumour cells dissociate from primary tumours, enter the circulation (circulating tumour cells, CTCs), and colonize sites in bone (disseminated tumour cells, DTCs). The bone marrow seems to be a particularly dormancy-inducing environment for DTCs, yet the mechanisms of dormancy initiation, reactivation, and ...
Rongchen Dai, Mengfan Liu, Xincheng Xiang, Zhichao Xi, Hongxi Xu   +4 more
openaire   +3 more sources

Restoring Tissue Homeostasis at Metastatic Sites: A Focus on Extracellular Vesicles in Bone Metastasis

Frontiers in Oncology, 2021
Bone is the most common site of cancer metastasis and the spread of cancer cells to the bone is associated with poor prognosis, pain, increased risk of fractures, and hypercalcemia.
Domenica Giannandrea, Valentina Citro, Elena Lesma, Monica Bignotto, Natalia Platonova, Raffaella Chiaramonte   +5 more
doaj   +1 more source