Results 11 to 20 of about 81,269 (285)

Substrate Stiffness Controls Osteoblastic and Chondrocytic Differentiation of Mesenchymal Stem Cells without Exogenous Stimuli [PDF]

, 2017
Stem cell fate has been linked to the mechanical properties of their underlying substrate, affecting mechanoreceptors and ultimately leading to downstream biological response.
Boyan, Barbara D., Doroudi, Maryam, Gall, Ken, Hyzy, Sharon L., Lee, Erin M., Olivares-Navarrete, Rene, Schwartz, Zvi, Smith, Kathryn, Williams, Joseph K.   +8 more
core   +15 more sources

Enhanced osteogenic differentiation in zoledronate-treated osteoporotic patients [PDF]

, 2017
Bisphosphonates are well known inhibitors of osteoclast activity and thus may be employed to influence osteoblast activity. The present study was designed to evaluate the in vivo effects of zoledronic acid (ZA) on the proliferation and osteoblastic ...
Carbonare, Luca Dalle, Dellantonio, Alessandra, Malerba, Giovanni, Mori, Antonio, Mottes, Monica, Plebani, Mario, Valenti, Maria Teresa, Zaninotto, Martina   +7 more
core   +9 more sources

Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation. [PDF]

PLoS ONE, 2012
Giant cell tumor of bone (GCT) is an aggressive bone tumor consisting of multinucleated osteoclast-like giant cells and proliferating osteoblast-like stromal cells.
Shalini Singh, Mohini Singh, Isabella W Y Mak, Robert Turcotte, Michelle Ghert   +4 more
doaj   +1 more source

The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature review

Frontiers in Oncology, 2023
Prostate cancer is the only human malignancy that generates predominantly osteoblastic bone metastases, and osteoblastic bone metastases account for more than 90% of osseous metastases of prostate cancer.
Xu Zhang, Peng Jiang, Chaojun Wang
doaj   +1 more source

MDA-MET-conditioned-medium augments the chemoattractant-dependent migration of MDA-MET cells towards hFOB-conditioned medium and increases collagenase activity

BMC Cancer, 2017
Background Metastasis of breast cancer displays site-specificity towards bone. Recently, studies have emerged indicating that primary tumors may remotely influence creation of a pre-metastatic niche.
Karis Chin-Quee, Henry J. Donahue
doaj   +1 more source

Prilocaine induces apoptosis in osteoblastic cells [PDF]

Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 1999
To determine whether prilocaine, a local anesthetic, induces apoptosis in osteoblastic cells.After reaching subconfluence, human osteoblastic Saos-2 and MG63 cells and mouse osteoblastic MC3T3-E1 cells were exposed for 48 hr to varying concentrations of prilocaine up to 10 mM and the cytotoxicity of the cells was analyzed by phase-contrast microscopy ...
K, Nakamura, H, Kido, Y, Morimoto, H, Morimoto, S, Kobayashi, M, Morikawa, T, Haneji   +6 more
openaire   +2 more sources

Wnt1 induces osteoblastic changes in a well‐established osteolytic skeletal metastatic model derived from breast cancer

Cancer Reports, 2023
Background Osteoblastic skeletal metastasis is frequently observed in prostate cancer. An effective therapy has not been developed due to the unclear molecular mechanism.
Aya Sugyo, Atsushi B. Tsuji, Hitomi Sudo, Yoshiya Sugiura, Mitsuru Koizumi, Tatsuya Higashi   +5 more
doaj   +1 more source

Proposal of a Novel Natural Biomaterial, the Scleral Ossicle, for the Development of Vascularized Bone Tissue In Vitro

Biomedicines, 2017
Recovering of significant skeletal defects could be partially abortive due to the perturbations that affect the regenerative process when defects reach a critical size, thus resulting in a non-healed bone.
Marta Checchi, Jessika Bertacchini, Giulia Grisendi, Alberto Smargiassi, Antonella Sola, Massimo Messori, Carla Palumbo   +6 more
doaj   +1 more source

Notch 1 Impairs Osteoblastic Cell Differentiation [PDF]

Endocrinology, 2003
Notch receptors are single pass transmembrane receptors activated by membrane-bound ligands with a role in cell proliferation and differentiation. As Notch 1 and 2 mRNAs are expressed by osteoblasts and induced by cortisol, we postulated that Notch could regulate osteoblastogenesis.
Maria, Sciaudone, Elisabetta, Gazzerro, Leah, Priest, Anne M, Delany, Ernesto, Canalis   +4 more
openaire   +2 more sources

RAGE Signaling in Skeletal Biology [PDF]

, 2019
PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M., Essex, Alyson L., Plotkin, Lilian I.   +2 more
core   +2 more sources