Results 11 to 20 of about 82,535 (276)

Osteoblasts as leukemia-initiating cells [PDF]

BoneKEy Reports, 2014
Commentary on: Kode A, Manavalan JS, Mosialou I, Bhagat G, Rathinam CV, Luo N, Khiabanian H, Lee A, Murty VV, Friedman R, Brum A, Park D, Galili N, Mukherjee S, Teruya-Feldstein J, Raza A, Rabadan R, Berman E, Kousteni S. Leukaemogenesis induced by an activating β-catenin mutation in osteoblasts. Nature 2014;506(7487):240–244. Hematopoietic stem and
Benjamin J, Frisch, Laura M, Calvi
openaire   +2 more sources

Antagonizing exosomal miR-18a-5p derived from prostate cancer cells ameliorates metastasis-induced osteoblastic lesions by targeting Hist1h2bc and activating Wnt/β-catenin pathway

Genes and Diseases, 2023
More than 50% of prostate cancer (PCa) patients have bone metastasis with osteoblastic lesions. MiR-18a-5p is associated with the development and metastasis of PCa, but it remains unclear whether it is involved in osteoblastic lesions.
Fanchun Zeng, Chunrong Zhao, Rujie Wang, Lingyan Ren, Hao Qiu, Zhi Zou, Haibin Ding, Zhongyi Sun, Jianmei Li, Shiwu Dong   +9 more
doaj   +1 more source

Downregulation of miR-184 facilitates osseous differentiation in periodontal ligament stem cells by modulating nuclear factor I-C

Journal of Dental Sciences, 2021
Background/purpose: PDLSCs (periodontal ligament stem cells), derived from dental tissues, are candidate cells for regeneration of dental tissues. MiRNAs could regulate osteogenic differentiation and the transformation into osteoblasts.
Chunying Li, Guanglin Duan, Yaopu Feng
doaj   +1 more source

Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation. [PDF]

PLoS ONE, 2012
Giant cell tumor of bone (GCT) is an aggressive bone tumor consisting of multinucleated osteoclast-like giant cells and proliferating osteoblast-like stromal cells.
Shalini Singh, Mohini Singh, Isabella W Y Mak, Robert Turcotte, Michelle Ghert   +4 more
doaj   +1 more source

The role of prostate-specific antigen in the osteoblastic bone metastasis of prostate cancer: a literature review

Frontiers in Oncology, 2023
Prostate cancer is the only human malignancy that generates predominantly osteoblastic bone metastases, and osteoblastic bone metastases account for more than 90% of osseous metastases of prostate cancer.
Xu Zhang, Peng Jiang, Chaojun Wang
doaj   +1 more source

MDA-MET-conditioned-medium augments the chemoattractant-dependent migration of MDA-MET cells towards hFOB-conditioned medium and increases collagenase activity

BMC Cancer, 2017
Background Metastasis of breast cancer displays site-specificity towards bone. Recently, studies have emerged indicating that primary tumors may remotely influence creation of a pre-metastatic niche.
Karis Chin-Quee, Henry J. Donahue
doaj   +1 more source

Prilocaine induces apoptosis in osteoblastic cells [PDF]

Canadian Journal of Anesthesia/Journal canadien d'anesthésie, 1999
To determine whether prilocaine, a local anesthetic, induces apoptosis in osteoblastic cells.After reaching subconfluence, human osteoblastic Saos-2 and MG63 cells and mouse osteoblastic MC3T3-E1 cells were exposed for 48 hr to varying concentrations of prilocaine up to 10 mM and the cytotoxicity of the cells was analyzed by phase-contrast microscopy ...
K, Nakamura, H, Kido, Y, Morimoto, H, Morimoto, S, Kobayashi, M, Morikawa, T, Haneji   +6 more
openaire   +2 more sources

Wnt1 induces osteoblastic changes in a well‐established osteolytic skeletal metastatic model derived from breast cancer

Cancer Reports, 2023
Background Osteoblastic skeletal metastasis is frequently observed in prostate cancer. An effective therapy has not been developed due to the unclear molecular mechanism.
Aya Sugyo, Atsushi B. Tsuji, Hitomi Sudo, Yoshiya Sugiura, Mitsuru Koizumi, Tatsuya Higashi   +5 more
doaj   +1 more source

Proposal of a Novel Natural Biomaterial, the Scleral Ossicle, for the Development of Vascularized Bone Tissue In Vitro

Biomedicines, 2017
Recovering of significant skeletal defects could be partially abortive due to the perturbations that affect the regenerative process when defects reach a critical size, thus resulting in a non-healed bone.
Marta Checchi, Jessika Bertacchini, Giulia Grisendi, Alberto Smargiassi, Antonella Sola, Massimo Messori, Carla Palumbo   +6 more
doaj   +1 more source

Glial cell line-derived neurotrophic factor influences proliferation of osteoblastic cells [PDF]

, 2012
Little is known about the role of neurotrophic growth factors in bone metabolism. This study investigated the short-term effects of glial cell line-derived neurotrophic factor (GDNF) on calvarial-derived MC3T3-E1 osteoblasts.
Airaksinen, Baldassarre, Ben A. Scheven, Chen, Costantini, Cuccuru, De Ceuninck, Declercq, Edery, Figiel, Forander, Frost, Gale, Gao, Garcia, Gattei, Gattei, Glass, Gowen, Hashino, Hefferan, Hellmich, Janssens, Jiang, Kashani, Krieglstein, Kuno, Kurozumi, Lencel, Li, Luukko, Modrowski, Nakayama, Nanes, Nosrat, Nosrat, Paratcha, Paul R. Cooper, Peterziel, Rawlinson, Remy, Remy, Robinson, Saarma, Sariola, Scheven, Scheven, Shi, Subramaniam, van den Bos, Wang, Wang, Yajima, Yan, Yanaga, Zins, Zoe Gale   +56 more
core   +2 more sources