Results 231 to 240 of about 65,828 (262)

Stromal Defense Against Cancer: An Unprecedented Mechanism Limiting Cancer Invasion Into the Bone

Cancer Science, Volume 117, Issue 2, Page 308-315, February 2026.
The roles of nonimmune systems in tumor regulation remain largely undefined. This article introduces a new concept, “stromal defense against cancer (SDAC),” which is based on recent findings that the periosteum actively responds to tumor proximity and physically impedes tumor invasion into bone.
Masayuki Tsukasaki, Hiroshi Takayanagi
wiley   +1 more source

A metabolic comparison of GIPR agonism versus GIPR antagonism in male mice

Diabetes, Obesity and Metabolism, Volume 28, Issue 2, Page 1160-1167, February 2026.
Abstract Aims Targeting the glucose dependent insulinotropic polypeptide receptor (GIPR) is of growing interest for treating type 2 diabetes and obesity, though the optimal approach remains unclear. Both GIPR agonism and antagonism, respectively, incorporated into drugs like tirzepatide and maridebart cafraglutide, have paradoxically both shown ...
Iona Davies, Alexandra Turland, Hanh Duyen Tran, Carissa Wong, Olivier Cahn, Cecilia Dunsterville, Yichang Sun, Yilin Xiao, Kevin G. Murphy, Stephen R. Bloom, Ben Jones, Tricia M. M. Tan   +11 more
wiley   +1 more source

Effect of metformin on inflammation and bone damage in a rat model of medication‐related osteonecrosis of the jaw

European Journal of Oral Sciences, Volume 134, Issue 1, February 2026.
Abstract This study investigated how chronic metformin administration modulates the cellular profile and inflammatory markers in a zoledronic acid‐based rat model of medication‐related osteonecrosis of the jaw (MRONJ). Male Wistar rats were allocated to different treatments: (i) naïve, (ii) MRONJ (zoledronic acid, 0.2 mg/kg, i.v.
Liviane Maria Alves Rabelo, Mariana Vasconcelos Guimarães, Aurilene Gomes Cajado, José Vitor Mota Lemos, Felipe Domingos de Sousa, Nylane Maria Nunes Alencar, Vilma de Lima, Paulo Goberlânio de Barros Silva, Ana Paula Negreiros Nunes Alves, Deysi Viviana Tenazoa Wong, Roberto César Pereira Lima‐Júnior   +10 more
wiley   +1 more source

Epigenetic regulation of osteoblast differentiation [PDF]

, 2022
openaire   +1 more source

Tooth–bone attachment tissue is produced by cells with a mixture of odontoblastic and osteoblastic features in reptiles

Journal of Anatomy, Volume 248, Issue 2, Page 251-268, February 2026.
Tooth attachment in vertebrates ranges from ligament‐based anchorage in mammals to direct fusion in many reptiles. In the veiled chameleon, we identified a transient cell population—termed ankyloblasts—at the tooth‐bone interface. These cells exhibit both odontoblast‐ and osteoblast‐like features.
M. Šulcová, J. Dumková, B. Hutečková, M. Kavková, V. Parobková, O. Zahradníček, J. Křivánek, I. Adameyko, J. Kaiser, T. Zikmund, A. S. Tucker, M. Buchtová   +11 more
wiley   +1 more source

The NLRP3 Inflammasome Regulates Orthodontic Tooth Movement

Orthodontics &Craniofacial Research, Volume 29, Issue 1, Page 134-143, February 2026.
ABSTRACT Objective The NLRP3 inflammasome is a damage sensor driving pyroptotic cell death during orthodontic tooth movement (OTM). Recent studies have revealed impaired one‐week OTM in mice lacking NLRP3. However, the relevance of NLRP3 during long‐term OTM remains unknown.
Lisa Latzko, Gerald Degenhart, Michael J. Blumer, Reinhard Gruber, Johannes Haybäck, Claudia Manzl, Adriano G. Crismani   +6 more
wiley   +1 more source

Lysophosphatidic Acid Synergizes With 1,25‐Dihydroxyvitamin D to Promote Fibroblast Growth Factor‐23 Synthesis via MAPK Signaling and Induction of the IL12A Gene

The FASEB Journal, Volume 40, Issue 1, 15 January 2026.
Ay et al. investigated the cellular mechanisms behind the role of lysophosphatidic acid (LPA) in FGF23 production. They revealed that LPA cooperates with 1,25‐dihydroxyvitamin D (1,25D), that is, the bioactive form of vitamin D known to stimulate FGF23 synthesis. This synergy entails MAPK signaling and the induction of the gene encoding the interleukin‐
Birol Ay, Sajin Marcus Cyr, Yorihiro Iwasaki, Elizabeth Hill, Eugene P. Rhee, Nevil J. Singh, Petra Simic, Murat Bastepe   +7 more
wiley   +1 more source

VEGFA promotes odonto/osteoblastic differentiation in dental pulp stem cells via ERK/p38 signaling. [PDF]

J Dent Sci
Okada Y, Kawashima N, Noda S, Murano H, Han P, Hashimoto K, Kaneko T, Okiji T.   +7 more
europepmc   +1 more source

PKCα suppresses osteoblastic differentiation

PKCα suppresses osteoblastic differentiation
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Bioenergetic Metabolism In Osteoblast Differentiation

Current Osteoporosis Reports, 2022
Osteoblasts are responsible for bone matrix production during bone development and homeostasis. Much is known about the transcriptional regulation and signaling pathways governing osteoblast differentiation. However, less is known about how osteoblasts obtain or utilize nutrients to fulfill the energetic demands associated with osteoblast ...
Leyao Shen, Guoli Hu, Courtney M. Karner
openaire   +2 more sources