Results 251 to 260 of about 65,828 (262)

Collagen Cross-Linking Influences Osteoblastic Differentiation

Calcified Tissue International, 2008
Osteoblasts synthesize collagen matrix, which itself regulates the differentiation of precursor cells into mature osteoblasts. They express lysyl oxidase (LOX), which is involved in the collagen cross-linking process. Lathyrogens, like ss-aminopropionitrile (ssAPN), inhibit the formation of a stable matrix.
C, Turecek, N, Fratzl-Zelman, M, Rumpler, B, Buchinger, S, Spitzer, R, Zoehrer, E, Durchschlag, K, Klaushofer, E P, Paschalis, F, Varga   +9 more
openaire   +2 more sources

Transcriptional profiling of human osteoblast differentiation

Journal of Cellular Biochemistry, 2003
AbstractOsteoblast differentiation is a key aspect of bone formation and remodeling. To further our understanding of the differentiation process, we have developed a collection of conditionally immortalized adult human osteoblast cell lines representing discrete stages of differentiation.
J, Billiard, R A, Moran, M Z, Whitley, M, Chatterjee-Kishore, K, Gillis, E L, Brown, B S, Komm, P V N, Bodine   +7 more
openaire   +2 more sources

Osteoblasts: Differentiation and Function

1993
Cells of the osteoblast lineage occupy a central position in bone metabolism. The formation of a structurally sound skeleton, with its strength and integrity conserved by constant remodeling, and the formation as well as activation of the major bone-resorbing cell, the osteoclast, are the result of direct and indirect influences of osteoblasts.
T. J. Martin, D. M. Findlay, J. K. Heath, K. W. Ng   +3 more
openaire   +1 more source

Differentiation of Osteoblasts on Pectin-Coated Titanium

Biomacromolecules, 2008
The gold standard for implant metals is titanium, and coatings such as collagen-I, RGD-peptide, chondroitin sulfate, and calcium phosphate have been used to modify its biocompatibility. We investigated how titanium coated with pectins, adaptable bioactive plant polysaccharides with anti-inflammatory effects, supports osteoblast differentiation.
Kokkonen, H., Cassinelli, C., Verhoef, R., Morra, M., Schols, H.A., Tuukkanen, J.   +5 more
openaire   +2 more sources

Osteosarcoma and Osteoblastic Differentiation

Clinical Orthopaedics and Related Research, 2007
In addition to changes in cellular pathways, loss of differentiation is a notable feature of osteosarcoma. We hypothesized that blocks to normal differentiation may be a common feature of osteosarcoma, and may be one of many critical events that occur during oncogenesis in osteosarcoma.
Rex C, Haydon, Hue H, Luu, Tong-Chuan, He   +2 more
openaire   +2 more sources

IGFBP-2 Directly Stimulates Osteoblast Differentiation: IGFBP-2 DIRECTLY STIMULATES OSTEOBLAST DIFFERENTIATION

2014
Insulin like growth factor binding protein two (IGFBP-2) is important for acquisition of normal bone mass in mice; however, the mechanism by which IGFBP-2 functions is not defined. These studies investigated the role of IGFBP-2 in stimulating osteoblast differentiation.
Rosen, Clifford J, Xi, Gang, Clemmons, David R, Wai, Christine, DeMambro, Victoria   +4 more
openaire   +1 more source

Regulation of Osteoblast Differentiation by Runx2

2009
Runx2 protein is first detected in preosteoblasts, and the expression is upregulated in immature osteoblasts, but downregulated in mature osteoblasts. Runx2 is the first transcription factor required for determination of the osteoblast lineage, while Sp7 and canonical Wnt-signaling further direct the fate of mesenchymal cells to osteoblasts, blocking ...
openaire   +2 more sources

Transcriptional control of osteoblast differentiation

Biochemical Society Transactions, 1998
Lian, Jane B., Stein, Gary S., Stein, Janet L., Van Wijnen, Andre J.   +3 more
openaire   +3 more sources

Tributyltin modulates osteoblast differentiation

Toxicology Letters, 2008
Merja Korkalainen, Maria Herlin, Arja Tamminen, Helen Håkansson, Matti Viluksela   +4 more
openaire   +1 more source

Osteoblast Differentiation

2020
openaire   +1 more source