Involvement of microRNAs in regulation of osteoblastic differentiation in mouse induced pluripotent stem cells. [PDF]
PLoS ONE, 2012 UNLABELLED: BACKGOROUND: MicroRNAs (miRNAs), which regulate biological processes by annealing to the 3'-untranslated region (3'-UTR) of mRNAs to reduce protein synthesis, have been the subject of recent attention as a key regulatory factor in cell ...
Hideharu Okamoto +5 more
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Separations, 2023 Osteoporosis, one of the most common bone diseases, results from an imbalance between bone formation and resorption. Osteoblasts are primarily involved in bone formation, whereas osteoclasts are involved in bone resorption. Therefore, any substances that
Eun-Sang Cho +5 more
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Hyaluronan inhibits BMP‐induced osteoblast differentiation [PDF]
FEBS Letters, 2015 Hyaluronan (HA), one of the major structural extracellular components in cartilage, regulates cellular responses via receptors such as CD44. However, the direct effects of HA on osteoblastic differentiation has not been studied in detail. Here, we investigated the effects of HA (molecular weight: 900–1200kDa) on osteoblastic differentiation that was ...
Kaneko, Keiko +6 more
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Differential Iron Requirements for Osteoblast and Adipocyte Differentiation
JBMR Plus, 2021 ABSTRACT Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external environment and signals act to direct the pathway of differentiation. Importantly, situations such as aging and chronic kidney disease display alterations in the
Daniel F. Edwards +7 more
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The Effect of Zoledronic Acid on BSP Expression and Methylation during Osteoblastic Differentiation of Mesenchymal Stem Cells [PDF]
پیاورد سلامت, 2011 Background and Aim: Bone sialoprotein (BSP) is a specific marker of osteoblastic differentiation. In this research, the effect of Zoledronic Acid on BSP expression and methylation status during osteoblastic differentiation of mesenchymal stem cells (MSCs)
M Mahmodi Niya Meymand +5 more
doaj +2 more sources
Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation. [PDF]
PLoS ONE, 2012 Giant cell tumor of bone (GCT) is an aggressive bone tumor consisting of multinucleated osteoclast-like giant cells and proliferating osteoblast-like stromal cells.
Shalini Singh +4 more
doaj +1 more source
RAGE Signaling in Skeletal Biology [PDF]
, 2019 PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M. +2 more
core +2 more sources
Biological Research, 2015 BACKGROUND: Mechanical strain plays a great role in growth and differentiation of osteoblast. A previous study indicated that integrin-β (β1, β5) mediated osteoblast proliferation promoted by mechanical tensile strain.
Qiangcheng Zeng +8 more
doaj +1 more source
Glial cell line-derived neurotrophic factor influences proliferation of osteoblastic cells [PDF]
, 2012 Little is known about the role of neurotrophic growth factors in bone metabolism. This study investigated the short-term effects of glial cell line-derived neurotrophic factor (GDNF) on calvarial-derived MC3T3-E1 osteoblasts.
Airaksinen +56 more
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Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts [PDF]
, 2019 Despite recent progress in its treatment, Multiple Myeloma (MM) remains incurable and its associated bone disease persists even after complete remission.
Atkinson, Emily G. +7 more
core +1 more source