Results 21 to 30 of about 894,587 (193)
MiR-423-5p downregulates osteoblastic differentiation and cell viability by targeting SMAD3 in non-traumatic osteonecrosis [PDF]
, 2022 Purpose: To investigate the potential role of miR-423-5p in osteoblastic differentiation of non-traumatic osteonecrosis of the femoral head (ONFH). Methods: MiR-423-5p levels in bone marrow samples from ONFH and osteoarthritis (OA) patients, respectively,
Zeng, Yun +5 more
core +1 more source
Relaxin treatment stimulates the differentiation of mesenchymal stem cells into osteoblasts
Journal of Dental Sciences, 2023 Background/purpose: Several studies have determined that relaxin stimulates differentiation and regulates the activity of mature osteoclasts, but little is known about its effect on the differentiation of mesenchymal cells towards the osteogenic lineage.
Lina M. Escobar +3 more
doaj +1 more source
Icariin attenuates the calcification of vascular smooth muscle cells through ERα – p38MAPK pathway
Aging Medicine, 2023 Objective To investigate the relationship between icariin and the osteoblastic differentiation of vascular smooth muscle cells (VSMCs) and the signal pathway involved.
Jieyu He +9 more
doaj +1 more source
Animal Cells and Systems, 2021 Titanium (Ti) is a widely used biomaterial for dental implants because of its outstanding biocompatibility for hard tissues. Osseointegration, the interaction between implanted biomaterials and living cells in bone, is essential for successful ...
Moon-Jin Jeong +5 more
doaj +1 more source
Molecules, 2021 Several signalling pathways, including the JAK/STAT signalling pathway, have been identified to regulate the differentiation of human bone marrow skeletal (mesenchymal) stem cells (hBMSCs) into bone-forming osteoblasts.
Nihal AlMuraikhi +5 more
doaj +1 more source
Differential Iron Requirements for Osteoblast and Adipocyte Differentiation
JBMR Plus, 2021 ABSTRACT Bone marrow mesenchymal progenitor cells are precursors for various cell types including osteoblasts, adipocytes, and chondrocytes. The external environment and signals act to direct the pathway of differentiation. Importantly, situations such as aging and chronic kidney disease display alterations in the
Daniel F. Edwards +7 more
openaire +4 more sources
Investigation of FGFR2-IIIC signaling via FGF-2 ligand for advancing GCT stromal cell differentiation. [PDF]
PLoS ONE, 2012 Giant cell tumor of bone (GCT) is an aggressive bone tumor consisting of multinucleated osteoclast-like giant cells and proliferating osteoblast-like stromal cells.
Shalini Singh +4 more
doaj +1 more source
p38 MAPK Signaling in Osteoblast Differentiation [PDF]
Frontiers in Cell and Developmental Biology, 2016 The skeleton is a highly dynamic tissue whose structure relies on the balance between bone deposition and resorption. This equilibrium, which depends on osteoblast and osteoclast functions, is controlled by multiple factors that can be modulated post-translationally.
Rodríguez Carballo, Edgardo +2 more
openaire +5 more sources
Mesenchymal Differentiation and Organ Distribution of Established Human Stromal Cell Lines in NOD/SCID Mice [PDF]
, 2001 Two human stromal cell lines were established previously from bone marrow-derived primary long-term cultures by immortalization using the SV40 large T antigen and cellular cloning. After irradiation, the fibroblast-like cell lines L87/4 and L88/5 support
Thalmeier, Karin +6 more
core +1 more source
Stem Cell Research & Therapy, 2021 Background Transplantation of human bone marrow stromal cells (hBMSCs) is a promising therapy for bone regeneration due to their ability to differentiate into bone forming osteoblastic cells.
Justyna Magdalena Kowal +6 more
doaj +1 more source