Results 1 to 10 of about 222,196 (348)

Proline-rich 15 depletion enhances Nrf2 cascade to promote osteoblast survival from oxidative injury [PDF]

Communications Biology
Reducing oxidative stress via enhancing Nrf2 cascade activation can efficiently protect osteoblasts. Here siRNA-based screening of nuclear proteins identified PRR15 (proline-rich 15) as a potential regulator of the Nrf2-ARE pathway in osteoblasts.
Zhiqiang Zhou, Zhi-gao Jin, Xiao-feng Qi, Ze-yu Qian, Tian-yu Shi, Peng Zhang, Chang-gong Lan, Yi Wang, Dong Liu   +8 more
doaj   +2 more sources

Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]

, 2013
Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch, A Brandao-Burch, A Gartland, A Hoebertz, BA Evans, CG Bellows, DC Genetos, DC Genetos, E Nakamura, G Burnstock, G Burnstock, G Burnstock, G Burnstock, H Fleisch, H Fleisch, H Zimmermann, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, Isabel R. Orriss, J Ham, JL Ramírez-Zacarías, JP Reyes, KA Buckley, KA Buckley, KA Johnson, L Hessle, Luc Malaval, M Ciciarello, M Romanello, Mark O. R. Hajjawi, Michelle L. Key, MP Abbracchio, MW Pfaffl, N Panupinthu, N Panupinthu, N Wang, N Zippel, RM Rumney, S Shimegi, S Syberg, Timothy R. Arnett, V Ralevic, WB Bowler, WE Razzell, WN Addison   +49 more
core   +23 more sources

Substrate Stiffness of Bone Microenvironment Controls Functions of Pre-Osteoblasts and Fibroblasts In Vitro

Biomimetics, 2023
The formation of bone in a bone defect is accomplished by osteoblasts, while the over activation of fibroblasts promotes fibrosis. However, it is not clear how the extracellular matrix stiffness of the bone-regeneration microenvironment affects the ...
Shenghan Gao, Bo Chen, Min Gao, Yue Xu, Xueyi Yang, Chun Yang, Shaoxia Pan   +6 more
doaj   +1 more source

Cellular and molecular mediators of bone metastatic lesions [PDF]

, 2018
Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia, Del Fattore, Andrea, Marampon, Francesco, Rossi, Michela   +3 more
core   +9 more sources

Nrf2 signaling activation by a small molecule activator compound 16 inhibits hydrogen peroxide-induced oxidative injury and death in osteoblasts

Cell Death Discovery, 2022
We explored the potential activity of compound 16 (Cpd16), a novel small molecule Nrf2 activator, in hydrogen peroxide (H2O2)-stimulated osteoblasts. In the primary murine/human osteoblasts and MC3T3-E1 murine osteoblastic cells, Cpd16 treatment at micro-
Jing-wei Zhao, Pei-jun Tang, Zhen-tao Zhou, Gang Xu, Quan Li, Ke-ran Li, Yue-huan Zheng   +6 more
doaj   +1 more source

Rifampicin restores extracellular organic matrix formation and mineralization of osteoblasts after intracellular Staphylococcus aureus infection

Bone & Joint Research, 2022
Aims: Bone regeneration during treatment of staphylococcal bone infection is challenging due to the ability of Staphylococcus aureus to invade and persist within osteoblasts.
Francisca I. Alagboso, Gopala K. Mannala, Nike Walter, Denitsa Docheva, Christoph Brochhausen, Volker Alt, Markus Rupp   +6 more
doaj   +1 more source

Osteoblast-Osteoclast Communication and Bone Homeostasis

Cells, 2020
Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell ...
Jung-Min Kim, Chujiao Lin, Zheni Stavre, Matthew B. Greenblatt, Jae-Hyuck Shim   +4 more
doaj   +1 more source

Biosafety of 3D printed titanium alloy porous materials to osteoblast cell line MC3T3-E1 [PDF]

Jichu yixue yu linchuang, 2020
Objective To prepare 3D-printed porous materials of titanium alloy by electron beaming melting (EBM) and to confirm its biosafety to osteoblasts (OB). Methods Three topological structures of titanium alloy porous materials (2.0 mm, 2.25 mm and 2.5 mm ...
JING Li, SHI Wen, CAO Yu, LIU Rui-sai, LIU Lu, LI Jian-yu, LIU Hui
doaj  

Effects of Mechanical Stress Stimulation on Function and Expression Mechanism of Osteoblasts

Frontiers in Bioengineering and Biotechnology, 2022
Osteoclasts and osteoblasts play a major role in bone tissue homeostasis. The homeostasis and integrity of bone tissue are maintained by ensuring a balance between osteoclastic and osteogenic activities.
Pan Liu, Pan Liu, Ji Tu, Wenzhao Wang, Zheng Li, Yao Li, Yao Li, Xiaoping Yu, Xiaoping Yu, Zhengdong Zhang, Zhengdong Zhang, Zhengdong Zhang   +11 more
doaj   +1 more source

Acidosis Is a Key Regulator of Osteoblast Ecto-Nucleotidase Pyrophosphatase/Phosphodiesterase 1 (NPP1) Expression and Activity [PDF]

, 2015
Previous work has shown that acidosis prevents bone nodule formation by osteoblasts in vitro by inhibiting mineralisation of the collagenous matrix.
Arnett, T R, Hajjawi, M O R, Key, M L, Millan, J L, Orriss, I R   +4 more
core   +2 more sources