Results 1 to 10 of about 262,778 (408)

Osteocytes as a record of bone formation dynamics: A mathematical model of osteocyte generation in bone matrix [PDF]

J Theor Biol 364: 418-427 (2015), 2014
The formation of new bone involves both the deposition of bone matrix, and the formation of a network of cells embedded within the bone matrix, called osteocytes. Osteocytes derive from bone-synthesising cells (osteoblasts) that become buried in bone matrix during bone deposition.
Buenzli, Pascal R
arxiv   +6 more sources

G protein-coupled receptor 91 activations suppressed mineralization in Porphyromonas gingivalis–infected osteoblasts [PDF]

Scientific Reports
Succinate receptor GPR91 is one of the G protein-coupled receptors (GPCRs) that interacts with various proteins to regulate diverse cellular functions such as cell morphology, apoptosis, and differentiation.
Wenqi Su, Dandan Zhang, Yujia Wang, Lang Lei, Houxuan Li   +4 more
doaj   +2 more sources

General analysis of mathematical models for bone remodeling [PDF]

arXiv, 2010
Bone remodeling is regulated by pathways controlling the interplay of osteoblasts and osteoclasts. In this work, we apply the method of generalized modelling to systematically analyse a large class of models of bone remodeling. Our analysis shows that osteoblast precursors can play an important role in the regulation of bone remodeling.
Gross, Thilo, Siegmund, Stefan, Stiefs, Dirk, Zumsande, Martin   +3 more
arxiv   +3 more sources

Spatio-temporal structure of cell distribution in cortical Bone Multicellular Units: a mathematical model [PDF]

Bone 48 (2011) 918-926, 2010
Bone remodelling maintains the functionality of skeletal tissue by locally coordinating bone-resorbing cells (osteoclasts) and bone-forming cells (osteoblasts) in the form of Bone Multicellular Units (BMUs). Understanding the emergence of such structured units out of the complex network of biochemical interactions between bone cells is essential to ...
Bird, Bronckers, Buenzli, Burger, D.W. Smith, Evans, Frost, Frost, Gori, Halmos, Harada, Iqbal, Ishii, Ishii, Jaworski, Jaworski, Komarova, Lauffenburger, Lemaire, Martin, Martin, P. Pivonka, P.R. Buenzli, Parfitt, Parfitt, Parfitt, Pivonka, Roodman, Ryser, Ryser, Scheurer, Tang, Thomas, van Oers, Väänänen, Wolfram Research   +35 more
arxiv   +4 more sources

Aerobic Glycolysis in Osteoblasts [PDF]

Current Osteoporosis Reports, 2014
Osteoblasts, the chief bone-making cells in the body, are a focus of osteoporosis research. Although teriparatide, a synthetic fragment of the human parathyroid hormone (PTH), has been an effective bone anabolic drug, there remains a clinical need for additional therapeutics that safely stimulates osteoblast number and function.
E. Esen, Fanxin Long
semanticscholar   +4 more sources

Extracellular ATP released by osteoblasts is a key local inhibitor of bone mineralisation [PDF]

, 2013
Previous studies have shown that exogenous ATP (>1µM) prevents bone formation in vitro by blocking mineralisation of the collagenous matrix. This effect is thought to be mediated via both P2 receptor-dependent pathways and a receptor-independent ...
A Brandao-Burch, A Brandao-Burch, A Gartland, A Hoebertz, BA Evans, CG Bellows, DC Genetos, DC Genetos, E Nakamura, G Burnstock, G Burnstock, G Burnstock, G Burnstock, H Fleisch, H Fleisch, H Zimmermann, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, IR Orriss, Isabel R. Orriss, J Ham, JL Ramírez-Zacarías, JP Reyes, KA Buckley, KA Buckley, KA Johnson, L Hessle, Luc Malaval, M Ciciarello, M Romanello, Mark O. R. Hajjawi, Michelle L. Key, MP Abbracchio, MW Pfaffl, N Panupinthu, N Panupinthu, N Wang, N Zippel, RM Rumney, S Shimegi, S Syberg, Timothy R. Arnett, V Ralevic, WB Bowler, WE Razzell, WN Addison   +49 more
core   +17 more sources

The diverse origin of bone‐forming osteoblasts

Journal of Bone and Mineral Research, 2021
Osteoblasts are the only cells that can give rise to bones in vertebrates. Thus, one of the most important functions of these metabolically active cells is mineralized matrix production.
T. Mizoguchi, N. Ono
semanticscholar   +1 more source

Substrate Stiffness of Bone Microenvironment Controls Functions of Pre-Osteoblasts and Fibroblasts In Vitro

Biomimetics, 2023
The formation of bone in a bone defect is accomplished by osteoblasts, while the over activation of fibroblasts promotes fibrosis. However, it is not clear how the extracellular matrix stiffness of the bone-regeneration microenvironment affects the ...
Shenghan Gao, Bo Chen, Min Gao, Yue Xu, Xueyi Yang, Chun Yang, Shaoxia Pan   +6 more
doaj   +1 more source

Nrf2 signaling activation by a small molecule activator compound 16 inhibits hydrogen peroxide-induced oxidative injury and death in osteoblasts

Cell Death Discovery, 2022
We explored the potential activity of compound 16 (Cpd16), a novel small molecule Nrf2 activator, in hydrogen peroxide (H2O2)-stimulated osteoblasts. In the primary murine/human osteoblasts and MC3T3-E1 murine osteoblastic cells, Cpd16 treatment at micro-
Jing-wei Zhao, Pei-jun Tang, Zhen-tao Zhou, Gang Xu, Quan Li, Ke-ran Li, Yue-huan Zheng   +6 more
doaj   +1 more source

Controlled oxygen plasma treatment of single-walled carbon nanotube films improves osteoblast cells attachment and enhances their proliferation [PDF]

Carbon, 49, 2926-2934 (2011), 2021
The effects of oxidative treatment of single-walled carbon nanotubes (SWCNTs) on the adhesion and proliferation of human osteoblasts (SAOS-2) were investigated. The surface properties of SWCNTs after oxygen plasma treatment were characterised by contact angle measurement, scanning electron microscopy and Raman spectroscopy.
arxiv   +1 more source