Results 11 to 20 of about 115,598 (217)

DKK1 Induced by 1,25D3 Is Required for the Mineralization of Osteoblasts

Cells, 2020
1α,25-dihydroxyvitamin D3 (1,25D3), the most popular drug for osteoporosis treatment, drives osteoblast differentiation and bone mineralization. Wnt/β-catenin signaling is involved in commitment and differentiation of osteoblasts, but the role ...
Sungsin Jo, Subin Yoon, So Young Lee, So Yeon Kim, Hyosun Park, Jinil Han, Sung Hoon Choi, Joong-Soo Han, Jae-Hyuk Yang, Tae-Hwan Kim   +9 more
doaj   +1 more source

The role of osteoblasts in regulating hematopoietic stem cell activity and tumor metastasis

Brazilian Journal of Medical and Biological Research, 2005
Bone marrow stromal cells are critical regulators of hematopoiesis. Osteoblasts are part of the stromal cell support system in bone marrow and may be derived from a common precursor.
K. Neiva, Y.-X. Sun, R.S. Taichman
doaj   +1 more source

Comparison of the Anabolic Effects of Reported Osteogenic Compounds on Human Mesenchymal Progenitor-derived Osteoblasts

Bioengineering, 2020
There is variability in the reported effects of compounds on osteoblasts arising from differences in experimental design and choice of cell type/origin.
Robert Owen, Hossein Bahmaee, Frederik Claeyssens, Gwendolen C. Reilly   +3 more
doaj   +1 more source

Bone Cell Exosomes and Emerging Strategies in Bone Engineering

Biomedicines, 2022
Bone tissue remodeling is a highly regulated process balancing bone formation and resorption through complex cellular crosstalk between resident bone and microenvironment cells.
Sanjana Vig, Maria Helena Fernandes
doaj   +1 more source

Transcriptomic comparison of osteopontin, osteocalcin and core binding factor 1 genes between human adipose derived differentiated osteoblasts and native osteoblasts

Advanced Biomedical Research, 2012
Background: There are significant limitations in repair of irrecoverable bone defects. Stem-cell therapy is a promising approach for the construction of bone tissue.
Vahid Bahrambeigi, Rasoul Salehi, Batool Hashemibeni, Ebrahim Esfandiari   +3 more
doaj   +1 more source

Increased local bone turnover in patients with chronic periprosthetic joint infection

Bone & Joint Research, 2023
Aims: The management of periprosthetic joint infection (PJI) remains a major challenge in orthopaedic surgery. In this study, we aimed to characterize the local bone microstructure and metabolism in a clinical cohort of patients with chronic PJI ...
Nico Hinz, Sebastian Butscheidt, Nico M. Jandl, Holger Rohde, Johannes Keller, Frank T. Beil, Jan Hubert, Tim Rolvien   +7 more
doaj   +1 more source

Research Progress of Paradoxical Bone Formation in Osteoporosis [PDF]

Zhongguo quanke yixue
Osteoporosis is a common clinical bone disease caused by a variety of causes, it increases osteoclast production mainly by changing the inflammatory microenvironment of the body, the end result is increased bone resorption and decreased bone mass ...
YANG Yang, GAO Xi
doaj   +1 more source

Staphylococcus aureus - induced tumor necrosis factor - related apoptosis - inducing ligand expression mediates apoptosis and caspase-8 activation in infected osteoblasts

BMC Microbiology, 2003
Background Staphylococcus aureus infection of normal osteoblasts induces expression of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL). Results Normal osteoblasts were incubated in the presence of purified bacterial products over a range ...
Bost Kenneth L, Anguita Juan, Marriott Ian, Rivera F, Alexander Emily H, Hudson Michael C   +5 more
doaj   +1 more source

Coumarin Ameliorates Impaired Bone Turnover by Inhibiting the Formation of Advanced Glycation End Products in Diabetic Osteoblasts and Osteoclasts

Biomolecules, 2020
Accumulating evidence demonstrates that the risk of osteoporotic fractures increases in patients with diabetes mellitus. Thus, diabetes-induced bone fragility has recently been recognized as a diabetic complication. As the fracture risk is independent of
Eun-Jung Lee, Min-Kyung Kang, Yun-Ho Kim, Dong Yeon Kim, Hyeongjoo Oh, Soo-Il Kim, Su Yeon Oh, Woojin Na, Young-Hee Kang   +8 more
doaj   +1 more source

MicroRNA-21: An Emerging Player in Bone Diseases

Frontiers in Pharmacology, 2021
MicroRNAs (MiRNAs) are small endogenous non-coding RNAs that bind to the 3′-untranslated region of target genes and promote their degradation or inhibit translation, thereby regulating gene expression. MiRNAs are ubiquitous in biology and are involved in
Chen Chen, Chen Chen, Ya-Mei Liu, Bin-Lan Fu, Liang-Liang Xu, Liang-Liang Xu, Bin Wang   +6 more
doaj   +1 more source