The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model [PDF]
, 2013 Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This
Ayati, Bruce P. +3 more
core +18 more sources
Local origins impart conserved bone type-related differences in human osteoblast behaviour [PDF]
, 2015 Osteogenic behaviour of osteoblasts from trabecular, cortical and subchondral bone were examined to determine any bone type-selective differences in samples from both osteoarthritic (OA) and osteoporotic (OP) patients.
Clarkin, C E +6 more
core +3 more sources
Acidosis Is a Key Regulator of Osteoblast Ecto-Nucleotidase Pyrophosphatase/Phosphodiesterase 1 (NPP1) Expression and Activity [PDF]
, 2015 Previous work has shown that acidosis prevents bone nodule formation by osteoblasts in vitro by inhibiting mineralisation of the collagenous matrix.
Arnett, T R +4 more
core +2 more sources
Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes [PDF]
, 2017 Identifying mechanisms by which cells of the osteoblastic lineage communicate in vivo is complicated by the mineralised matrix that encases osteocytes, and thus, vital mechanoadaptive processes used to achieve load‐bearing integrity remain unresolved. We
Aarden +83 more
core +3 more sources
Exenatide Improves Bone Quality in a Murine Model of Genetically Inherited Type 2 Diabetes Mellitus [PDF]
, 2017 Type 2 diabetes mellitus (T2DM) is associated with skeletal complications, including an increased risk of fractures. Reduced blood supply and bone strength may contribute to this skeletal fragility.
Andreozzi +64 more
core +6 more sources
The role of osteoblasts in regulating hematopoietic stem cell activity and tumor metastasis
Brazilian Journal of Medical and Biological Research, 2005 Bone marrow stromal cells are critical regulators of hematopoiesis. Osteoblasts are part of the stromal cell support system in bone marrow and may be derived from a common precursor.
K. Neiva, Y.-X. Sun, R.S. Taichman
doaj +1 more source
Osteocytes as a record of bone formation dynamics: A mathematical model of osteocyte generation in bone matrix [PDF]
, 2014 The formation of new bone involves both the deposition of bone matrix, and the formation of a network of cells embedded within the bone matrix, called osteocytes.
Buenzli, Pascal R
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Increased local bone turnover in patients with chronic periprosthetic joint infection
Bone & Joint Research, 2023 Aims: The management of periprosthetic joint infection (PJI) remains a major challenge in orthopaedic surgery. In this study, we aimed to characterize the local bone microstructure and metabolism in a clinical cohort of patients with chronic PJI ...
Nico Hinz +7 more
doaj +1 more source
Myocyte enhancer factor 2C: an osteoblast transcription factor identified by DMSO enhanced mineralization [PDF]
, 2011 Free to read on publisher website Rapid mineralization of cultured osteoblasts could be a useful characteristic in stem-cell mediated therapies for fracture and other orthopaedic problems. Dimethyl sulfoxide (DMSO) is a small amphipathic solvent molecule
Bacic-Welsh, Desa +6 more
core +2 more sources
Advanced Biomedical Research, 2012 Background: There are significant limitations in repair of irrecoverable bone defects. Stem-cell therapy is a promising approach for the construction of bone tissue.
Vahid Bahrambeigi +3 more
doaj +1 more source