Results 41 to 50 of about 136,319 (308)

NLRP3 Inflammasome: A New Target for Prevention and Control of Osteoporosis?

open access: yesFrontiers in Endocrinology, 2021
Osteoporosis is a systemic bone metabolism disease that often causes complications, such as fractures, and increases the risk of death. The nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3 (NLRP3) inflammasome is ...
Na Jiang   +9 more
doaj   +1 more source

Enhancement of Bone Morphogenetic Protein-2 Expression and Bone Formation by Coumarin Derivatives Via P38 and Erk-Dependent Pathway in Osteoblasts

open access: yes, 2009
Osteoporosis is a reduction in skeletal mass due to an imbalance between bone resorption and bone formation. Bone morphogenetic protein (BMP) plays important roles in osteoblastic differentiation and bone formation.
TANG, CHIH-HSIN;YANG, RONG-SEN;CHIEN, MEI-YIN;CHEN, CHIEN-CHIH;FU, WEN -MEI   +1 more
core   +1 more source

Osteoblast Differentiation at a Glance [PDF]

open access: yesMedical Science Monitor Basic Research, 2016
Ossification is a tightly regulated process, performed by specialized cells called osteoblasts. Dysregulation of this process may cause inadequate or excessive mineralization of bones or ectopic calcification, all of which have grave consequences for human health.
Rutkovskiy, Arkady   +2 more
openaire   +2 more sources

Human Osteoblast Migration in DC Electrical Fields Depends on Store Operated Ca2+-Release and Is Correlated to Upregulation of Stretch-Activated TRPM7 Channels

open access: yesFrontiers in Bioengineering and Biotechnology, 2019
Fracture healing and bone regeneration, particularly in the elderly, remains a challenge. There is an ongoing search for methods to activate osteoblasts, and the application of electrical fields is an attractive approach in this context.
Marco Rohde   +13 more
doaj   +1 more source

Grafting effectiveness of Anadara granosa shell combined with sardinella longiseps gel on the number of osteoblast-osteoclast cells

open access: yesDental Journal, 2017
Background: Bone grafts derived from Anadara granosa shells contain calcium carbonate that possesses bone-healing properties. The combination of Sardinella Longiceps fish oil, containing EPA and DHA, and Anadara granosa shells was assumed to regulate the
Eddy Hermanto   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Strontium and osteoblast function [PDF]

open access: yesOsteoporosis International, 2015
Dear Editor, We thank Drs. Xie and Ye [1] for their interest in our paper [2] and address their main comments below. Firstly, we were careful to acknowledge the contrasting findings of other published studies, both in vitro and in vivo. We do not know of any evidence to support the assertion of Drs.
D P, Wornham   +3 more
openaire   +2 more sources

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

open access: yesFEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin   +3 more
wiley   +1 more source

Molecular mechanisms of skeletal tissue formation

open access: yesJournal of Physical Fitness and Sports Medicine, 2013
Vertebrate skeleton consists of numerous pieces of bone and cartilage, each placed at the appropriate anatomical site by an elaborate regulatory process in developmental patterning.
Akira Nifuji
doaj   +1 more source

Exploring In Vitro Biological Cellular Responses of Pegylated β-Cyclodextrins

open access: yesMolecules, 2022
βCDPEG5 and βCDPEG2 are two derivatives comprising seven PEG linear chains of 5 and 2 kDa, respectively, conjugated to βCD. As βCDPEGs display different physicochemical properties than their precursors, they could also trigger distinct cellular responses.
Juliana Rincón-López   +4 more
doaj   +1 more source

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