Results 21 to 30 of about 112,140 (265)

MicroRNA-21: An Emerging Player in Bone Diseases

Frontiers in Pharmacology, 2021
MicroRNAs (MiRNAs) are small endogenous non-coding RNAs that bind to the 3′-untranslated region of target genes and promote their degradation or inhibit translation, thereby regulating gene expression. MiRNAs are ubiquitous in biology and are involved in
Chen Chen, Chen Chen, Ya-Mei Liu, Bin-Lan Fu, Liang-Liang Xu, Liang-Liang Xu, Bin Wang   +6 more
doaj   +1 more source

Acid-Induced Inflammatory Cytokines in Osteoblasts: A Guided Path to Osteolysis in Bone Metastasis

Frontiers in Cell and Developmental Biology, 2021
Bone metastasis (BM) is a dismal complication of cancer that frequently occurs in patients with advanced carcinomas and that often manifests as an osteolytic lesion.
Gemma Di Pompo, Costantino Errani, Robert Gillies, Laura Mercatali, Toni Ibrahim, Jacopo Tamanti, Nicola Baldini, Nicola Baldini, Sofia Avnet, Sofia Avnet   +9 more
doaj   +1 more source

Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells

Bioengineering, 2018
Mesenchymal stem/stromal cells (MSCs) are typically characterised by their ability to differentiate into skeletal (osteogenic, chondrogenic and adipogenic) lineages.
Julia Marshall, Amanda Barnes, Paul Genever   +2 more
doaj   +1 more source

NLRP3 Inflammasome: A New Target for Prevention and Control of Osteoporosis?

Frontiers in Endocrinology, 2021
Osteoporosis is a systemic bone metabolism disease that often causes complications, such as fractures, and increases the risk of death. The nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3 (NLRP3) inflammasome is ...
Na Jiang, Jinyang An, Kuan Yang, Jinjin Liu, Jinjin Liu, Conghui Guan, Conghui Guan, Chengxu Ma, Xulei Tang, Xulei Tang   +9 more
doaj   +1 more source

Strontium and osteoblast function [PDF]

Osteoporosis International, 2015
Dear Editor, We thank Drs. Xie and Ye [1] for their interest in our paper [2] and address their main comments below. Firstly, we were careful to acknowledge the contrasting findings of other published studies, both in vitro and in vivo. We do not know of any evidence to support the assertion of Drs.
D P, Wornham, M O, Hajjawi, I R, Orriss, T R, Arnett   +3 more
openaire   +2 more sources

Human Osteoblast Migration in DC Electrical Fields Depends on Store Operated Ca2+-Release and Is Correlated to Upregulation of Stretch-Activated TRPM7 Channels

Frontiers in Bioengineering and Biotechnology, 2019
Fracture healing and bone regeneration, particularly in the elderly, remains a challenge. There is an ongoing search for methods to activate osteoblasts, and the application of electrical fields is an attractive approach in this context.
Marco Rohde, Josefin Ziebart, Timo Kirschstein, Tina Sellmann, Katrin Porath, Friederike Kühl, Bachir Delenda, Christian Bahls, Ursula van Rienen, Ursula van Rienen, Rainer Bader, Rainer Bader, Rüdiger Köhling, Rüdiger Köhling   +13 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Grafting effectiveness of Anadara granosa shell combined with sardinella longiseps gel on the number of osteoblast-osteoclast cells

Dental Journal, 2017
Background: Bone grafts derived from Anadara granosa shells contain calcium carbonate that possesses bone-healing properties. The combination of Sardinella Longiceps fish oil, containing EPA and DHA, and Anadara granosa shells was assumed to regulate the
Eddy Hermanto, Rima Parwati Sari, Asri Cahyadita Dwi Imaniar, Kevin Anggoro   +3 more
doaj   +1 more source

Early‐life high‐fat diet exposure increases Achilles tendon stiffness and induces transcriptomic alterations

FEBS Open Bio, EarlyView.
Early‐life exposure to a high‐fat diet altered intact Achilles tendons in rat offspring, making them thinner, stiffer, and molecularly distinct even without injury. These findings suggest that developmental high‐fat diet exposure may impair tendon quality and increase susceptibility to mechanical overload or tendon injury later in life.
Heyong Yin, Ziyang Yuan, Wenli Jiang, Ai Guo   +3 more
wiley   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source