Results 61 to 70 of about 197,419 (304)

Biophysical Modulation of the Mitochondrial Metabolism and Redox in Bone Homeostasis and Osteoporosis: How Biophysics Converts into Bioenergetics

Antioxidants, 2021
Bone-forming cells build mineralized microstructure and couple with bone-resorbing cells, harmonizing bone mineral acquisition, and remodeling to maintain bone mass homeostasis.
Feng-Sheng Wang, Re-Wen Wu, Yu-Shan Chen, Jih-Yang Ko, Holger Jahr, Wei-Shiung Lian   +5 more
doaj   +1 more source

Raman Microscopy at the Organic–Inorganic Interfaces in Human Calcified Aortic Valves Shows the Co‐Existence of Whitlockite Crystals and Carbonated Hydroxyapatite‐Mineralized Collagen Fibrils

Advanced Functional Materials, EarlyView.
This study advances our understanding of aortic valve stenosis by capturing spatially resolved chemical and structural changes at the nanoscale. The findings highlight the potential of combined Raman and electron microscopy for understanding calcification mechanisms across diverse tissue types.
Robin H. M. Van der Meijden, Carolien T. A Kuster, Amber van Broekhoven, Raphaela Allgayer, Luco Rutten, Rona Roverts, Marta Cerruti, Elena Macías‐Sánchez, Jan Hein Cornel, Salloua el Messaoudi, Anat Akiva, Nico Sommerdijk   +11 more
wiley   +1 more source

Comparison of phenotypic characterization between differentiated osteoblasts from stem cells and Calvaria osteoblasts In vitro

International Journal of Preventive Medicine, 2013
Background: Characteristics of differentiated osteoblasts from adipose derived stem cells (ADSCs) in compared with isolated osteoblasts from normal bone such as calvaria are unknown.
Batool Hashemibeni, Farzaneh Jafary, Nafiseh Esmaeil, Vahid Goharian, Ghader Feizi, Fariba Heidari, Sayyedeh Zahra Moosavi-Nejad, Sayyed Hamid Zarkesh   +7 more
doaj  

Characterization and In Vitro Cytotoxicity Safety Screening of Fractionated Organosolv Lignin on Diverse Primary Human Cell Types Commonly Used in Tissue Engineering

Biology, 2022
There is limited data assessing the cytotoxic effects of organosolv lignin with cells commonly used in tissue engineering. Structural and physico-chemical characterization of fractionated organosolv lignin showed that a decrease of the molecular weight ...
Jules A. Menima-Medzogo, Kathrin Walz, Jasmin C. Lauer, Gopakumar Sivasankarapillai, F. Robert Gleuwitz, Bernd Rolauffs, Marie-Pierre Laborie, Melanie L. Hart   +7 more
doaj   +1 more source

Self‐Assembled Nanoclay Gel With Spheroid MSC‐Derived Exosome Mimetics to Integrate Demineralized Bone Matrix and Noggin‐Targeting miRNA for Synergistic Osteogenesis

Advanced Functional Materials, EarlyView.
We report a versatile nanoclay gel carrier platform that enhances the osteogenic efficacy of demineralized bone matrix (DBM) by integrating nanoclay‐based self‐assembly with cell‐derived exosome mimetics loaded with noggin‐targeting miR‐200c. This design amplifies BMP signaling, thereby promoting DBM‐mediated osteogenesis and offering a promising ...
Changlu Xu, Zhi Li, Minjee Kang, Ruoyu Sheng, Bing Han, Yiqing Chen, Tara Aghaloo, Min Lee   +7 more
wiley   +1 more source

Proline-rich 15 depletion enhances Nrf2 cascade to promote osteoblast survival from oxidative injury

Communications Biology
Reducing oxidative stress via enhancing Nrf2 cascade activation can efficiently protect osteoblasts. Here siRNA-based screening of nuclear proteins identified PRR15 (proline-rich 15) as a potential regulator of the Nrf2-ARE pathway in osteoblasts.
Zhiqiang Zhou, Zhi-gao Jin, Xiao-feng Qi, Ze-yu Qian, Tian-yu Shi, Peng Zhang, Chang-gong Lan, Yi Wang, Dong Liu   +8 more
doaj   +1 more source

The Floor‐Ceiling‐Chip, or 2 × 2D = Pseudo‐3D—Approaching 3D Cell Morphology and Organization between Two Opposing 2D Substrates with Cell‐Adhesive Protein Micropatterns

Advanced Healthcare Materials, EarlyView.
Here, we present a novel 3D cell patterning and culture platform. The “Floor‐Ceiling‐Chip” (FC‐Chip) consists of two opposing track‐etched membranes, creating a pseudo‐3D microenvironment for the cells in between. By providing the membranes with micropatterned cell‐adhesive islands of varying geometries and sizes, the FC‐Chip enables control over cell ...
Urandelger Tuvshindorj, Francesca Giacomini, Esra Güben Kaçmaz, Tim ten Brink, Lorenzo Moroni, Zeinab Tahmasebi Birgani, Clemens van Blitterswijk, Pamela Habibović, Stefan Giselbrecht, Jan de Boer, Roman Truckenmüller   +10 more
wiley   +1 more source

Spatial Distribution of Macrophages During Callus Formation and Maturation Reveals Close Crosstalk Between Macrophages and Newly Forming Vessels [PDF]

, 2019
Macrophages are essential players in the process of fracture healing, acting by remodeling of the extracellular matrix and enabling vascularization. Whilst activated macrophages of M1-like phenotype are present in the initial pro-inflammatory phase of ...
Aulich, Linus, Buttgereit, Frank, Duda, Georg N., Fiedler, Alexander F., Gaber, Timo, Hauser, Anja E., Köhler, Markus, Lang, Annemarie, Niesner, Raluca A., Rauch, Ariana, Schmidt-Bleek, Katharina, Stefanowski, Jonathan   +11 more
core   +1 more source

Laser‐Assisted Processing and Modification of Bioactive Glasses: A Review

Advanced Healthcare Materials, EarlyView.
Laser technologies provide powerful tools to process and transform bioactive glasses for advanced biomedical applications. This review discusses laser‐matter interaction mechanisms, laser surface engineering, and laser‐assisted fabrication of scaffolds and nanofibers.
Antonio Riveiro, Mario González‐Quintas, Mónica Fernández‐Arias, Jesús del Val, Félix Quintero, Rafael Comesaña, Fernando Lusquiños, Julian R. Jones, Juan Pou   +8 more
wiley   +1 more source

Multiple verification in computational modeling of bone pathologies

, 2011
We introduce a model checking approach to diagnose the emerging of bone pathologies. The implementation of a new model of bone remodeling in PRISM has led to an interesting characterization of osteoporosis as a defective bone remodeling dynamics with ...
A. Aziz, D.T. Gillespie, E. Bartocci, E. Bartocci, E. Bartocci, Emanuela Merelli, Erik de Vink, G. Karsenty, Ion Petre, L.J. Raggatt, M. Calder, M. Kwiatkowska, M. Kwiatkowska, N. Paoletti, Nicola Paoletti, P. Lió, Pietro Liò, R. Barbuti, R. Hanada, S. Jabbar, S.C. Manolagas, T.E. Pronk   +21 more
core   +2 more sources