Results 31 to 40 of about 222,196 (348)

Acid-Induced Inflammatory Cytokines in Osteoblasts: A Guided Path to Osteolysis in Bone Metastasis

Frontiers in Cell and Developmental Biology, 2021
Bone metastasis (BM) is a dismal complication of cancer that frequently occurs in patients with advanced carcinomas and that often manifests as an osteolytic lesion.
Gemma Di Pompo, Costantino Errani, Robert Gillies, Laura Mercatali, Toni Ibrahim, Jacopo Tamanti, Nicola Baldini, Nicola Baldini, Sofia Avnet, Sofia Avnet   +9 more
doaj   +1 more source

Analysis of the Intrinsic Self-Organising Properties of Mesenchymal Stromal Cells in Three-Dimensional Co-Culture Models with Endothelial Cells

Bioengineering, 2018
Mesenchymal stem/stromal cells (MSCs) are typically characterised by their ability to differentiate into skeletal (osteogenic, chondrogenic and adipogenic) lineages.
Julia Marshall, Amanda Barnes, Paul Genever   +2 more
doaj   +1 more source

NLRP3 Inflammasome: A New Target for Prevention and Control of Osteoporosis?

Frontiers in Endocrinology, 2021
Osteoporosis is a systemic bone metabolism disease that often causes complications, such as fractures, and increases the risk of death. The nucleotide-binding oligomerization domain-like-receptor family pyrin domain-containing 3 (NLRP3) inflammasome is ...
Na Jiang, Jinyang An, Kuan Yang, Jinjin Liu, Jinjin Liu, Conghui Guan, Conghui Guan, Chengxu Ma, Xulei Tang, Xulei Tang   +9 more
doaj   +1 more source

Alterations in the self-renewal and differentiation ability of bone marrow mesenchymal stem cells in a mouse model of rheumatoid arthritis [PDF]

, 2010
Introduction: Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease primarily involving the synovium. Evidence in recent years has suggested that the bone marrow (BM) may be involved, and may even be the initiating site of the disease ...
Bellantuono, I., Coulton, L., Croucher, P.I., Gambardella, A., Hughes, D., Kottam, L., Mohanty, S.T., Nicklin, M.J., Wilson, A.G.   +8 more
core   +3 more sources

Human Osteoblast Migration in DC Electrical Fields Depends on Store Operated Ca2+-Release and Is Correlated to Upregulation of Stretch-Activated TRPM7 Channels

Frontiers in Bioengineering and Biotechnology, 2019
Fracture healing and bone regeneration, particularly in the elderly, remains a challenge. There is an ongoing search for methods to activate osteoblasts, and the application of electrical fields is an attractive approach in this context.
Marco Rohde, Josefin Ziebart, Timo Kirschstein, Tina Sellmann, Katrin Porath, Friederike Kühl, Bachir Delenda, Christian Bahls, Ursula van Rienen, Ursula van Rienen, Rainer Bader, Rainer Bader, Rüdiger Köhling, Rüdiger Köhling   +13 more
doaj   +1 more source

Primary cultures of chick osteocytes retain functional gap junctions between osteocytes and between osteocytes and osteoblasts [PDF]

, 2008
The inaccessibility of osteocytes due to their embedment in the calcified bone matrix in vivo has precluded direct demonstration that osteocytes use gap junctions as a means of intercellular communication.
Ishihara, Yoshihito, Kamioka, Hiroshi, Lim, Soo-Siang, Murshid, Sakhr A., Ris, Hans, Sugawara, Yasuyo, Yamamoto, Teruko Takano   +6 more
core   +1 more source

Grafting effectiveness of Anadara granosa shell combined with sardinella longiseps gel on the number of osteoblast-osteoclast cells

Dental Journal, 2017
Background: Bone grafts derived from Anadara granosa shells contain calcium carbonate that possesses bone-healing properties. The combination of Sardinella Longiceps fish oil, containing EPA and DHA, and Anadara granosa shells was assumed to regulate the
Eddy Hermanto, Rima Parwati Sari, Asri Cahyadita Dwi Imaniar, Kevin Anggoro   +3 more
doaj   +1 more source

Ceramic identity contributes to mechanical properties and osteoblast behavior on macroporous composite scaffolds. [PDF]

, 2012
Implants formed of metals, bioceramics, or polymers may provide an alternative to autografts for treating large bone defects. However, limitations to each material motivate the examination of composites to capitalize on the beneficial aspects of ...
Genetos, Damian C, Leach, J Kent, Morales-Hernandez, Diana G, Murphy, Kaitlin C, Working, David M   +4 more
core   +4 more sources

Mathematical modelling of the pathogenesis of multiple myeloma-induced bone disease [PDF]

, 2014
Multiple myeloma (MM) is the second most common haematological malignancy and results in destructive bone lesions. The interaction between MM cells and the bone microenvironment plays an important role in the development of the tumour cells and MM ...
Blum B, Eriksen EF, Klein B, Lipton A, Mundy GR, Schmitt CP, Shay G   +6 more
core   +1 more source

PYCR1 inhibition in bone marrow stromal cells enhances bortezomib sensitivity in multiple myeloma cells by altering their metabolism

Molecular Oncology, EarlyView.
This study investigated how PYCR1 inhibition in bone marrow stromal cells (BMSCs) indirectly affects multiple myeloma (MM) cell metabolism and viability. Culturing MM cells in conditioned medium from PYCR1‐silenced BMSCs impaired oxidative phosphorylation and increased sensitivity to bortezomib.
Inge Oudaert, Lauren van den Broecke, Osman Aksoy, Judith Lind, Sonia Vallet, Arne Van der Vreken, Gamze Ates, Ann Massie, Ken Maes, Kim De Veirman, Elke De Bruyne, Karin Vanderkerken, Klaus Podar, Eline Menu   +13 more
wiley   +1 more source