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Osteoclast receptors and signaling
Archives of Biochemistry and Biophysics, 2008Osteoclasts are bone-resorbing cells derived from hematopoietic precursors of the monocyte-macrophage lineage. Besides the well known Receptor Activator of Nuclear factor-kappaB (RANK), RANK ligand and osteoprotegerin axis, a variety of factors tightly regulate osteoclast formation, adhesion, polarization, motility, resorbing activity and life span ...
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Journal of Cellular Biochemistry, 1994
AbstractIn biological research, new ideas arise and quickly spread to encompass the entire field. Thus, the evolution of molecular biology has significantly changed our methods of approaching our research. A similar far‐reaching finding has been the advent of radical reactions into biology.
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AbstractIn biological research, new ideas arise and quickly spread to encompass the entire field. Thus, the evolution of molecular biology has significantly changed our methods of approaching our research. A similar far‐reaching finding has been the advent of radical reactions into biology.
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Regulation of Differentiated Osteoclasts
Critical Reviews in Eukaryotic Gene Expression, 2000Osteoclasts respond to many factors, including endocrines, cytokines, cell-cell interactions, and cell-matrix contacts. For mature osteoclasts, the first level of control occurs through signaling that follows binding to an appropriate substrate. Mononuclear and multinucleate osteoclasts are activated when cell surface integrins, notably but not ...
C V, Gay, J A, Weber
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Bone Cells Required for Osteoclastic Resorption but Not for Osteoclastic Differentiation
Biochemical and Biophysical Research Communications, 1996It is generally considered that osteoblastic cells are essential for osteoclast formation. We tested the ability of hemopoietic tissue to differentiate osteoclastic characteristics in the absence of osteoblastic cells. We found that large numbers of calcitonin-receptor positive (CTRP) cells can be induced by prostaglandin E2 and 1,25(OH)2 vitamin D3 ...
A.C. Gallagher, T.J. Chambers, J. Owens
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2013
Osteoclasts are the principal, perhaps only, cells capable of destroying bone. They are highly motile cells, usually multinucleated, and of hemopoietic origin. Osteoclasts excavate characteristic pits and trails on bone by pumping protons to solubilize the mineral component (hydroxyapatite) and secreting cathepsin K, an enzyme that partly degrades the ...
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Osteoclasts are the principal, perhaps only, cells capable of destroying bone. They are highly motile cells, usually multinucleated, and of hemopoietic origin. Osteoclasts excavate characteristic pits and trails on bone by pumping protons to solubilize the mineral component (hydroxyapatite) and secreting cathepsin K, an enzyme that partly degrades the ...
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2011
Publisher Summary One of the integral cell types contributes significantly to regulation of bone mass; osteoblasts, of mesenchymal origin, are transducers of numerous endocrine and paracrine signals. Separately they secrete and calcify the unique bone matrix, which is degraded by myeloid derived osteoclasts.
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Publisher Summary One of the integral cell types contributes significantly to regulation of bone mass; osteoblasts, of mesenchymal origin, are transducers of numerous endocrine and paracrine signals. Separately they secrete and calcify the unique bone matrix, which is degraded by myeloid derived osteoclasts.
openaire +2 more sources