Results 11 to 20 of about 130,158 (334)
Interleukin-32 promotes osteoclast differentiation but not osteoclast activation.
PLoS ONE, 2009 BackgroundInterleukin-32 (IL-32) is a newly described cytokine produced after stimulation by IL-2 or IL-18 and IFN-gamma. IL-32 has the typical properties of a pro-inflammatory mediator and although its role in rheumatoid arthritis has been recently ...
Guillaume Mabilleau, Afsie Sabokbar
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The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation [PDF]
, 2010 Background: Clock genes and their protein products regulate circadian rhythms in mammals but have also been implicated in various physiological processes, including bone formation.
AE Hoffman +46 more
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Accelerated Lactate Dehydrogenase Activity Potentiates Osteoclastogenesis via NFATc1 Signaling. [PDF]
PLoS ONE, 2016 Osteoclasts seem to be metabolic active during their differentiation and bone-resorptive activation. However, the functional role of lactate dehydrogenase (LDH), a tetrameric enzyme consisting of an A and/or B subunit that catalyzes interconversion of ...
Heejin Ahn +6 more
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This is not an osteoclast [PDF]
Blood, 2016 ![Figure][1] A 64-year-old man with immunoglobulin A κ multiple myeloma was treated initially with bortezomib, thalidomide, dexamethasone, and daratumumab, an anti-CD38 antibody. After 4 cycles, the monoclonal component had decreased from 27 g/L to 8 g/L.
Adriana Plesa, Pierre Sujobert
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Scientific Reports, 2023 Osteoclasts degrade bone and osteoclast differentiation has been implicated in bone destruction in rheumatoid arthritis. The dairy bacterium Propionibacterium freudenreichii MJ2 (MJ2) isolated from raw milk inhibits osteoclast differentiation and ...
Jiah Yeom +3 more
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Ceritinib (LDK378) prevents bone loss via suppressing Akt and NF-κB-induced osteoclast formation
Frontiers in Endocrinology, 2022 BackgroundCeritinib is used for the treatment of patients with anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC), who are at the risk of developing bone metastasis.
Wenxin He +7 more
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CYP27A1 deficiency promoted osteoclast differentiation [PDF]
PeerJ, 2023 Background The elevating osteoclast differentiation can lead to an imbalance in bone homeostasis, which was responsible for bone loss and bone diseases, such as osteoporosis. Multiple pathways and molecules have been involved in osteoclast formation, but
Ziqi Fang +3 more
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Osteoclasts and Arthritis [PDF]
Journal of Bone and Mineral Research, 2009 INFLAMMATORY ARTHRITIS TYPICALLY presents as joint pain, swelling, and stiffness, which may be of short duration. For example, parvovirus B 19 infection, attended by painful polyarticular swelling, generally resolves spontaneously within 2 wk without joint destruction.
Georg Schett, Steven L. Teitelbaum
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Communications Biology, 2023 Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical
Weijia Sun +21 more
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Vitamin Regulation of Osteoclast Differentiation
Central Asian Journal of Medical Sciences, 2020 Objectives: Vitamins play critical roles in cellular metabolism, growth, and many enzymatic processes of the human body. They are also crucial in signal transduction and transcription pathways of many processes, including osteoclast differentiation. This
Erdenezaya Odkhuu +5 more
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