Results 31 to 40 of about 75,182 (264)

Diabetes Medication Metformin Inhibits Osteoclast Formation and Activity in In Vitro Models for Periodontitis

Frontiers in Cell and Developmental Biology, 2022
Diabetes and periodontitis are comorbidities and may share common pathways. Several reports indicate that diabetes medication metformin may be beneficial for the periodontal status of periodontitis patients.
Lucy Y. Tao, Lucy Y. Tao, Katarzyna B. Łagosz-Ćwik, Jolanda M.A. Hogervorst, Ton Schoenmaker, Aleksander M. Grabiec, Tim Forouzanfar, Fridus A. van der Weijden, Teun J. de Vries   +8 more
doaj   +1 more source

Effect of mitophagy in the formation of osteomorphs derived from osteoclasts

iScience, 2023
Summary: Osteoclasts are specialized multinucleated giant cells with unique bone-destroying capacities. A recent study revealed that osteoclasts undergo an alternative cell fate by dividing into daughter cells called osteomorphs. To date, no studies have
Tingben Huang, Yuchen Wang, Zhou Yu, Xiaoyan Miao, Zhiwei Jiang, Ke Yu, Mengdie Fu, Kaichen Lai, Ying Wang, Guoli Yang   +9 more
doaj   +1 more source

Interleukin-20 Acts as a Promotor of Osteoclastogenesis and Orthodontic Tooth Movement

Stem Cells International, 2021
Objectives. Bones constitute organs that are engaged in constant self-remodelling. Osteoblast and osteoclast homeostasis during remodelling contribute to overall skeletal status.
Yuanbo Liu, Yilong Ai, Xuan Sun, Bowen Meng, Xi Chen, Dongle Wu, Lei Gan, Benyi Yang, Chaoran Fu, Yilin Wu, Yang Cao   +10 more
doaj   +1 more source

Osteoclast Fusion and Fission [PDF]

Calcified Tissue International, 2012
Osteoclasts are specialized multinucleated cells with the unique capacity to resorb bone. Despite insight into the various steps of the interaction of osteoclast precursors leading to osteoclast formation, surprisingly little is known about what happens with the multinucleated cell itself after it has been formed.
Jansen, I.D.C., Vermeer, J.A.F., Bloemen, V., Stap, J., Everts, V.   +4 more
openaire   +6 more sources

BAP1 promotes osteoclast function by metabolic reprogramming

Nature Communications, 2023
Treatment of osteoporosis commonly diminishes osteoclast number which suppresses bone formation thus compromising fracture prevention. Bone formation is not suppressed, however, when bone degradation is reduced by retarding osteoclast functional ...
Nidhi Rohatgi, Wei Zou, Yongjia Li, Kevin Cho, Patrick L. Collins, Eric Tycksen, Gaurav Pandey, Carl J. DeSelm, Gary J. Patti, Anwesha Dey, Steven L. Teitelbaum   +10 more
doaj   +1 more source

INTRAVASCULAR OSTEOCLASTS [PDF]

The Journal of Bone and Joint Surgery. British volume, 1957
1. In five out of eleven cases of osteoclastoma it was found that osteoclasts were present inside clearly defined blood vessels either within the tumours or in the tissues immediately surrounding the tumours. In two further cases it was found that osteoclasts protruded into the vessels although they were not lying free within the vessels. 2.
openaire   +2 more sources

Stability of Medicinal Nanoemulsions to Spaceflight: Insights From the StarMed Experiment

Advanced Healthcare Materials, EarlyView.
Chitosan‐coated melatonin nanoemulsions (MN) recovered from a sounding rocket mission preserve droplet size and controlled‐release behavior, whereas uncoated nanoemulsions show ageing‐driven droplet growth and increased accessible drug fraction. Simple polymer coatings thus enhance the flight resilience of liquid space medicines under cumulative launch
Modupe Adebowale, Nguyen Van Duc Long, Philip M. Williams, Jens Hauslage, Volker Hessel   +4 more
wiley   +1 more source

Lipid Nanoparticle Co‐Delivery of mRNA and a Small Molecule Drug for Oral Cancer Chemoimmunotherapy

Advanced Materials, EarlyView.
Co‐encapsulation of p53 mRNA and the small molecule ciclopirox within a lipid nanoparticle yields an all‐in‐one chemoimmunotherapy for oral squamous cell carcinoma. The platform engages caspase‐driven apoptosis in cancer cells while repolarizing tumor‐associated macrophages, achieving tumor reduction in both p53‐susceptible and p53‐resistant models and
Marshall S. Padilla, Jacqueline J. Li, Qunzhou Zhang, Korey Patwari, Shihong Shi, Hannah M. Yamagata, Ryann A. Joseph, Briyanna N. Hymms, Sridatta V. Teerdhala, Emily Fitzgerald, Ori Z. Chalom, Kushol Gupta, Mohamad‐Gabriel Alameh, Drew Weissman, Anh D. Le, Michael J. Mitchell   +15 more
wiley   +1 more source

Endogenous Collagenases Regulate Osteoclast Fusion

Biomolecules, 2020
The precise regulation of osteoclast differentiation and function is crucial for the maintenance of healthy bone. Despite several reports of collagenase expression in bone tissues, the precise isoform expression as well as the role in osteoclasts are ...
Hyo Jeong Kim, Youngkyun Lee
doaj   +1 more source

The Origin of Osteoclasts

Immunobiology, 1982
We are satisfied from studies with mi mi osteopetrotic mutant mice that osteoclasts arise from the myeloid tissue of bone marrow and not as formerly proposed from osteoprogenitor cells. Grafts of compatible normal myeloid cells cure the osteopetrosis by the substitution of the qualitatively defective osteoclasts with normal ones.
J F, Loutit, N W, Nisbet
openaire   +2 more sources