Results 21 to 30 of about 100,119 (298)

Mechanical stimulation controls osteoclast function through the regulation of Ca2+-activated Cl− channel Anoctamin 1

Communications Biology, 2023
Mechanical force loading is essential for maintaining bone homeostasis, and unloading exposure can lead to bone loss. Osteoclasts are the only bone resorbing cells and play a crucial role in bone remodeling. The molecular mechanisms underlying mechanical
Weijia Sun, Yuheng Li, Jianwei Li, Yingjun Tan, Xinxin Yuan, Haoye Meng, Jianting Ye, Guohui Zhong, XiaoYan Jin, Zizhong Liu, Ruikai Du, Wenjuan Xing, Dingsheng Zhao, Jinping Song, Youyou Li, Junjie Pan, Yunzhang Zhao, Qi Li, Aiyuan Wang, Shukuan Ling, Rongji Dai, Yingxian Li   +21 more
doaj   +1 more source

Ceritinib (LDK378) prevents bone loss via suppressing Akt and NF-κB-induced osteoclast formation

Frontiers in Endocrinology, 2022
BackgroundCeritinib is used for the treatment of patients with anaplastic lymphoma kinase (ALK)-rearranged non-small cell lung cancer (NSCLC), who are at the risk of developing bone metastasis.
Wenxin He, Wenxin He, Wenxin He, Xiankun Cao, Keyu Kong, Kewei Rong, Shuai Han, An Qin   +7 more
doaj   +1 more source

Origin of Osteoclasts: Osteoclast Precursor Cells

Journal of Bone Metabolism, 2023
Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling for health and disease. Since the discovery of osteoclasts in 1873, the structure and function of osteoclasts and the molecular and cellular mechanisms of osteoclastogenesis have been extensively studied.
Jefferson Tsai, Kaichi Kaneko, Andrew J. Suh, Richard Bockman, Kyung-Hyun Park-Min   +4 more
openaire   +2 more sources

Vitamin Regulation of Osteoclast Differentiation

Central Asian Journal of Medical Sciences, 2020
Objectives: Vitamins play critical roles in cellular metabolism, growth, and many enzymatic processes of the human body. They are also crucial in signal transduction and transcription pathways of many processes, including osteoclast differentiation. This
Erdenezaya Odkhuu, Shijir Narmandakh, Munkhjargal Zinamyadar, Juramt Bold, Avirmed Amgalanbaatar, Enebish Sundui   +5 more
doaj   +1 more source

Surface proteins of Propionibacterium freudenreichii MJ2 inhibit RANKL-induced osteoclast differentiation by lipocalin-2 upregulation and lipocalin-2-mediated NFATc1 inhibition

Scientific Reports, 2023
Osteoclasts degrade bone and osteoclast differentiation has been implicated in bone destruction in rheumatoid arthritis. The dairy bacterium Propionibacterium freudenreichii MJ2 (MJ2) isolated from raw milk inhibits osteoclast differentiation and ...
Jiah Yeom, Seongho Ma, Dong Joon Yim, Young-Hee Lim   +3 more
doaj   +1 more source

Complex dynamics of osteoclast formation and death in long-term cultures. [PDF]

PLoS ONE, 2008
BACKGROUND: Osteoclasts, cells responsible for bone resorption, contribute to the development of degenerative, metabolic and neoplastic bone diseases, which are often characterized by persistent changes in bone microenvironment.
Timur Akchurin, Tayeb Aissiou, Naomi Kemeny, Erin Prosk, Nilima Nigam, Svetlana V Komarova   +5 more
doaj   +1 more source

BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1

Cell & Bioscience, 2022
Background Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role in bone absorption.
Yufeng Zhang, Min Yang, Sheng Zhang, Zhiqiang Yang, Yufan Zhu, Yi Wang, Zhe Chen, Xuan Lv, Zan Huang, Yuanlong Xie, Lin Cai   +10 more
doaj   +1 more source

Effect on Osteoclast Differentiation and ER Stress Downregulation by Amygdalin and RANKL Binding Interaction

Biomolecules, 2022
Bone diseases such as osteoporosis are the result of osteoclast over-activation. There are many therapeutic agents from natural compounds inhibiting the formation of osteoclast that have been reported and are continuously being interested. Amygdalin (AD)
Nguyen Minh Trang, Eun-Nam Kim, Hyun-Su Lee, Gil-Saeng Jeong   +3 more
doaj   +1 more source

Involvement of Noncoding RNAs in the Differentiation of Osteoclasts

Stem Cells International, 2020
As the most important bone-resorbing cells, osteoclasts play fundamental roles in bone remodeling and skeletal health. Much effort has been focused on identifying the regulators of osteoclast metabolism.
Yi Zhao, Lingfei Jia, Yunfei Zheng, Weiran Li   +3 more
doaj   +1 more source

Retinoic acid increases proliferation of human osteoclast progenitors and inhibits RANKL-stimulated osteoclast differentiation by suppressing RANK. [PDF]

PLoS ONE, 2010
It has been shown that high vitamin A intake is associated with bone fragility and fractures in both animals and humans. However, the mechanism by which vitamin A affects bones is unclear. In the present study, the direct effects of retinoic acid (RA) on
Lijuan Hu, Thomas Lind, Anders Sundqvist, Annica Jacobson, Håkan Melhus   +4 more
doaj   +1 more source