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Life, 2022 (1) Background: Osteoporosis is a disease in which bones are weakened and fractured easily because of various factors. It is mainly observed in elderly and postmenopausal women, and it continues to carry high economic costs in aging societies.
Yongjin Lee +5 more
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The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors. [PDF]
PLoS ONE, 2018 Inflammatory bone diseases, including rheumatoid arthritis, periodontitis and peri-implantitis, are associated not only with the production of inflammatory cytokines but also with local oxidative status, which is defined by intracellular reactive oxygen ...
Yoko Ohyama +4 more
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Advances in the Regulation of Osteoclasts and Osteoclast Functions [PDF]
Journal of Dental Research, 2013 Osteoclasts are derived from mononuclear hematopoietic myeloid lineage cells, which are formed in the bone marrow and are attracted to the bloodstream by factors, including sphingsine-1 phosphate. These circulating precursors are attracted to bone surfaces undergoing resorption by chemokines and other factors expressed at these sites, where they fuse ...
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From osteoblast to osteoclast: new insights of Yin-Yang theory in bone remodeling
World Journal of Traditional Chinese Medicine, 2015 Yin-Yang theory plays critical role in traditional Chinese medicine (TCM) science. However, there are many competing interpretations of Yin-Yang theory in the context with the development in biology, and no consensus has been established.
Dong-Feng Zhao +7 more
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Osteoclast Differentiation [PDF]
Critical Reviews in Oral Biology & Medicine, 1991 The osteoclast is the primary bone resorbing cell. It is a highly specialized multinucleated cell whose primary function is to help in the control of calcium homeostasis. The osteoclast has been very difficult to study because of its relative inaccessability, low numbers, and fragility when isolated from bone.
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Frontiers in Cell and Developmental Biology, 2020 Protein kinase C delta (PKC-δ) functions as an important regulator in bone metabolism. However, the precise involvement of PKC-δ in the regulation of osteoclasts remains elusive.
Shangfu Li +24 more
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Arachidonic acid and docosahexaenoic acid suppress osteoclast formation and activity in human CD14+ monocytes, in vitro. [PDF]
PLoS ONE, 2015 An unbalanced diet can have adverse effects on health. Long chain polyunsaturated fatty acids (LCPUFAs) have been the focus of research owing to their necessity of inclusion in a healthy diet. However, the effects of LCPUFAs on human osteoclast formation
Abe E Kasonga +3 more
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Frontiers in Pharmacology, 2020 Excessive bone resorption conducted by osteoclasts is considered as the main cause of osteoclast-related bone diseases such as osteoporosis. Therefore, the suppression of excessive osteoclast formation and function is one of the strategies to treat ...
Yu Yuan +15 more
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RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
Molecular Medicine, 2023 Background The cytoskeletal architecture of osteoclasts (OCs) and bone resorption activity must be appropriately controlled for proper bone remodeling, which is associated with osteoporosis.
Jirong Wang +8 more
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Osteoclasts and hematopoiesis [PDF]
BoneKEy Reports, 2012 The skeletal tissue is closely associated with the hematopoietic tissue lodged in its inner cavities. Besides the well-known role of the endosteal osteoblasts in the maintenance of the hematopoietic stem cell (HSC) niche, it is an emerging concept that osteoclasts are involved in the regulation of hematopoiesis as well, although published data are ...
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