Results 41 to 50 of about 127,619 (299)

RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling

Molecular Medicine, 2023
Background The cytoskeletal architecture of osteoclasts (OCs) and bone resorption activity must be appropriately controlled for proper bone remodeling, which is associated with osteoporosis.
Jirong Wang, Chengyun Xu, Jing Zhang, Yizhong Bao, Ying Tang, Xiaoling Lv, Bo Ma, Ximei Wu, Genxiang Mao   +8 more
doaj   +1 more source

Effect of mitophagy in the formation of osteomorphs derived from osteoclasts

iScience, 2023
Summary: Osteoclasts are specialized multinucleated giant cells with unique bone-destroying capacities. A recent study revealed that osteoclasts undergo an alternative cell fate by dividing into daughter cells called osteomorphs. To date, no studies have
Tingben Huang, Yuchen Wang, Zhou Yu, Xiaoyan Miao, Zhiwei Jiang, Ke Yu, Mengdie Fu, Kaichen Lai, Ying Wang, Guoli Yang   +9 more
doaj   +1 more source

Strontium potently inhibits mineralisation in bone-forming primary rat osteoblast cultures and reduces numbers of osteoclasts in mouse marrow cultures [PDF]

, 2014
The basic mechanisms by which strontium ranelate acts on bone are still unclear. We show that an important action of strontium salts is to block calcification in cultures of osteoblasts, the bone-forming cells.
A Barbara, A Caudrillier, AF Donneau, AS Hurtel-Lemaire, C Roux, D. P. Wornham, E Bonnelye, E Canalis, F Yang, FE McCaslin, G Boivin, GJ Atkins, GM Blake, HB Pan, I Schrooten, I Schrooten, I Schrooten, I. R. Orriss, IR Orriss, IR Orriss, IR Orriss, J Christoffersen, JJ Patel, JY Reginster, JY Reginster, M Grynpas, M Yamaguchi, M. O. Hajjawi, MA Karsdal, MS Rybchyn, N Chattopadhyay, N Takahashi, O Bruyere, O Fromigue, P Ammann, P Zioupos, PC D’Haese, PJ Marie, PJ Marie, PJ Marie, PJ Marie, PJ Meunier, SC Verberckmoes, SC Verberckmoes, T. R. Arnett   +44 more
core   +3 more sources

Effects of RANKL-Targeted Therapy in Immunity and Cancer. [PDF]

, 2014
The role of the receptor activator of nuclear factor-κB ligand (RANKL)/RANK system is well characterized within bone, where RANKL/RANK signaling mediates osteoclastogenesis and bone resorption.
Cheng, Michael L, Fong, Lawrence
core   +2 more sources

Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model

, 2011
In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU).
Anderson, Baron, Beysens, Block, Boyce, Boyde, Britz, Bronckers, Buenzli, Burger, Chambers, Civitelli, Cohen, Cooper, David W. Smith, Drasdo, Drasdo, Everts, Frost, Frost, Fukushima, García-Aznar, Gerlee, Ghaemi, Glauber, Glazier, Grynpas, Helfrich, Huang, Jaworski, Jeon, Junhwan Jeon, Manolagas, Mansury, Markus, Martin, Martin, Martin, Martin, Martin, Matsuoka, Miller, Mombach, Moshin, Nishiyama, Noble, Othmer, Othmer, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Pascal R. Buenzli, Peruani, Peter Pivonka, Peter T. Cummings, Poplawski, Robling, Roodman, Ryser, Schienbein, Schilling, Schweitzer, Stout, Susa, Tappen, van Kampen, van Oers, van Oers, Väänänen, Walker, Zhang   +74 more
core   +2 more sources

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]

, 2017
Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran, Blyth, Karen, Charlesworth, Gemma, Daroszewska, Anna, Ford, Catriona, King, Ayala, Leung, Hing Y., Loveridge, Carolyn J., Mui, Ernest J., Prior, Amanda, Rose, Lorraine, Salji, Mark, Sansom, Owen, Tan, Ee Hong, van ’t Hof, Rob J., Welsh, Michelle   +15 more
core   +2 more sources

Diabetes Medication Metformin Inhibits Osteoclast Formation and Activity in In Vitro Models for Periodontitis

Frontiers in Cell and Developmental Biology, 2022
Diabetes and periodontitis are comorbidities and may share common pathways. Several reports indicate that diabetes medication metformin may be beneficial for the periodontal status of periodontitis patients.
Lucy Y. Tao, Lucy Y. Tao, Katarzyna B. Łagosz-Ćwik, Jolanda M.A. Hogervorst, Ton Schoenmaker, Aleksander M. Grabiec, Tim Forouzanfar, Fridus A. van der Weijden, Teun J. de Vries   +8 more
doaj   +1 more source

Towards a New Spatial Representation of Bone Remodeling [PDF]

, 2012
Irregular bone remodeling is associated with a number of bone diseases such as osteoporosis and multiple myeloma. Computational and mathematical modeling can aid in therapy and treatment as well as understanding fundamental biology.
Ayati, Bruce P., Graham, Jason M., Martin, James A., Ramakrishnan, Prem S.   +3 more
core   +2 more sources

Osteoprotegerin reduces osteoclast resorption activity without affecting osteogenesis on nanoparticulate mineralized collagen scaffolds. [PDF]

, 2019
The instructive capabilities of extracellular matrix-inspired materials for osteoprogenitor differentiation have sparked interest in understanding modulation of other cell types within the bone regenerative microenvironment.
Bischoff, David, Dewey, Marley J, Foulad, David, Harley, Brendan AC, He, Tong-Chuan, Lee, Justine C, Miller, Timothy A, Reid, Russell R, Ren, Xiaoyan, Tiffany, Aleczandria S, Yamaguchi, Dean T, Zhou, Qi   +11 more
core  

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source