Results 41 to 50 of about 77,987 (262)
Frontiers in Pharmacology, 2020 Excessive bone resorption conducted by osteoclasts is considered as the main cause of osteoclast-related bone diseases such as osteoporosis. Therefore, the suppression of excessive osteoclast formation and function is one of the strategies to treat ...
Yu Yuan +15 more
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RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
Molecular Medicine, 2023 Background The cytoskeletal architecture of osteoclasts (OCs) and bone resorption activity must be appropriately controlled for proper bone remodeling, which is associated with osteoporosis.
Jirong Wang +8 more
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Streptococcal Mannose Phosphotransferase System Component IID Is a Novel RANK-Binding Osteoclastogenic Factor. [PDF]
Adv Sci (Weinh)Streptococcal mannose phosphotransferase system component IID (Man‐PTSIID) is identified as a novel RANK‐binding osteoclastogenic factor. By directly binding to RANK and activating NF‐κB independently of TLR2, Man‐PTSIID drives osteoclastogenesis and inflammatory bone destruction, uncovering an unexpected microbial mechanism underlying streptococcal ...
Park C +13 more
europepmc +2 more sources
Frontiers in Cell and Developmental Biology, 2022 Diabetes and periodontitis are comorbidities and may share common pathways. Several reports indicate that diabetes medication metformin may be beneficial for the periodontal status of periodontitis patients.
Lucy Y. Tao +8 more
doaj +1 more source
Osteoclast Fusion and Fission [PDF]
Calcified Tissue International, 2012 Osteoclasts are specialized multinucleated cells with the unique capacity to resorb bone. Despite insight into the various steps of the interaction of osteoclast precursors leading to osteoclast formation, surprisingly little is known about what happens with the multinucleated cell itself after it has been formed.
Jansen, I.D.C. +4 more
openaire +7 more sources
Effect of mitophagy in the formation of osteomorphs derived from osteoclasts
iScience, 2023 Summary: Osteoclasts are specialized multinucleated giant cells with unique bone-destroying capacities. A recent study revealed that osteoclasts undergo an alternative cell fate by dividing into daughter cells called osteomorphs. To date, no studies have
Tingben Huang +9 more
doaj +1 more source
Immunobiology, 1982 We are satisfied from studies with mi mi osteopetrotic mutant mice that osteoclasts arise from the myeloid tissue of bone marrow and not as formerly proposed from osteoprogenitor cells. Grafts of compatible normal myeloid cells cure the osteopetrosis by the substitution of the qualitatively defective osteoclasts with normal ones.
J F, Loutit, N W, Nisbet
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Interleukin-20 Acts as a Promotor of Osteoclastogenesis and Orthodontic Tooth Movement
Stem Cells International, 2021 Objectives. Bones constitute organs that are engaged in constant self-remodelling. Osteoblast and osteoclast homeostasis during remodelling contribute to overall skeletal status.
Yuanbo Liu +10 more
doaj +1 more source
BAP1 promotes osteoclast function by metabolic reprogramming
Nature Communications, 2023 Treatment of osteoporosis commonly diminishes osteoclast number which suppresses bone formation thus compromising fracture prevention. Bone formation is not suppressed, however, when bone degradation is reduced by retarding osteoclast functional ...
Nidhi Rohatgi +10 more
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Advanced Science, EarlyView.Mesenchymal stromal cells (MSCs) show promise for treating immune‐related disorders through immunomodulation and tissue regeneration. This review gives a brief overview of current clinical approval of MSC therapies. It also discussed how bioengineering, including genetic modification, biomaterial delivery, extracellular vesicles, and iPSC‐derived MSCs,
Sichen Yang +6 more
wiley +1 more source