Results 41 to 50 of about 100,119 (298)

Arachidonic acid and docosahexaenoic acid suppress osteoclast formation and activity in human CD14+ monocytes, in vitro. [PDF]

PLoS ONE, 2015
An unbalanced diet can have adverse effects on health. Long chain polyunsaturated fatty acids (LCPUFAs) have been the focus of research owing to their necessity of inclusion in a healthy diet. However, the effects of LCPUFAs on human osteoclast formation
Abe E Kasonga, Vishwa Deepak, Marlena C Kruger, Magdalena Coetzee   +3 more
doaj   +1 more source

The T-cell oncogene Tal2 is a Target of PU.1 and upregulated during osteoclastogenesis [PDF]

, 2013
Transcription factors play a crucial role in regulating differentiation processes during human life and are important in disease. The basic helix-loop-helix transcription factors Tal1 and Lyl1 play a major role in the regulation of gene expression in the
Stefanie Herkt, Hussong, Helge, Helge Hussong, Christian Mücke, Jörn Lausen, Herkt, Stefanie, Nadine Courtial, Courtial, Nadine, Stephan Kolodziej, Kolodziej, Stephan, Lausen, Jörn, Mücke, Christian, Mücke Christian, Kolodziej Stephan, Courtial Nadine, Lausen Jörn, Hussong Helge, Herkt Stefanie   +17 more
core   +1 more source

Osteoclast origins and occurrences.

, 2021
Osteoclast origins and occurrences.
Bregje W. M. de Wildt (11648899), Eva S. R. Spaander (11648905), Stefan J. A. Remmers (11648896), Rob B. M. de Vries (11648908), Michelle A. M. Vis (11648902), Sandra Hofmann (488242), Keita Ito (446796)   +6 more
core   +1 more source

Conditional Knockout of PKC-δ in Osteoclasts Favors Bone Mass Accrual in Males Due to Decreased Osteoclast Function

Frontiers in Cell and Developmental Biology, 2020
Protein kinase C delta (PKC-δ) functions as an important regulator in bone metabolism. However, the precise involvement of PKC-δ in the regulation of osteoclasts remains elusive.
Shangfu Li, Shangfu Li, Shangfu Li, Tianwei He, Tianwei He, Tianwei He, Depeng Wu, Depeng Wu, Depeng Wu, Liangming Zhang, Liangming Zhang, Liangming Zhang, Ruiqiang Chen, Ruiqiang Chen, Ruiqiang Chen, Bin Liu, Bin Liu, Bin Liu, Jinbo Yuan, Jennifer Tickner, An Qin, Jiake Xu, Limin Rong, Limin Rong, Limin Rong   +24 more
doaj   +1 more source

RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling

Molecular Medicine, 2023
Background The cytoskeletal architecture of osteoclasts (OCs) and bone resorption activity must be appropriately controlled for proper bone remodeling, which is associated with osteoporosis.
Jirong Wang, Chengyun Xu, Jing Zhang, Yizhong Bao, Ying Tang, Xiaoling Lv, Bo Ma, Ximei Wu, Genxiang Mao   +8 more
doaj   +1 more source

Fumitremorgin C Attenuates Osteoclast Formation and Function via Suppressing RANKL-Induced Signaling Pathways

Frontiers in Pharmacology, 2020
Excessive bone resorption conducted by osteoclasts is considered as the main cause of osteoclast-related bone diseases such as osteoporosis. Therefore, the suppression of excessive osteoclast formation and function is one of the strategies to treat ...
Yu Yuan, Yu Yuan, Yu Yuan, Kai Chen, Kai Chen, Xi Chen, Chao Wang, Heng Qiu, Zhen Cao, Dezhi Song, Youqiang Sun, Jianmin Guo, Jianmin Guo, Jennifer Tickner, Jiake Xu, Jun Zou   +15 more
doaj   +1 more source

Thioredoxin-2 Alleviates Osteoporosis by Restraining FOXO3a Nuclear Translocation. [PDF]

Adv Sci (Weinh)
Endothelial TRX2 preserves bone homeostasis by retaining FOXO3a at mitochondria and limiting TRAIL production. Loss of TRX2 or oxidative stress releases FOXO3a for nuclear translocation, increasing endothelial TRAIL secretion and driving osteoclast formation and bone loss.
Zhan C, Zhou Z, Ding Y, Lian R, Li X, Zhang X, Cao J, Tang Z, Lin Z, Song Z, He F.   +10 more
europepmc   +2 more sources

Diabetes Medication Metformin Inhibits Osteoclast Formation and Activity in In Vitro Models for Periodontitis

Frontiers in Cell and Developmental Biology, 2022
Diabetes and periodontitis are comorbidities and may share common pathways. Several reports indicate that diabetes medication metformin may be beneficial for the periodontal status of periodontitis patients.
Lucy Y. Tao, Lucy Y. Tao, Katarzyna B. Łagosz-Ćwik, Jolanda M.A. Hogervorst, Ton Schoenmaker, Aleksander M. Grabiec, Tim Forouzanfar, Fridus A. van der Weijden, Teun J. de Vries   +8 more
doaj   +1 more source

Monocyte Chemotactic Protein-1 (MCP1) Accumulation in Human Osteoclast Precursor Cultures

, 2022
In vitro osteoclast methods require constant treatment with macrophage colony stimulating factor (M-CSF) to support precursor survival and addition of the differentiation agent receptor activator of NF-κB ligand (RANKL).
Morrison, Nigel A., Forwood, Mark R, Nigel A. Morrison, Morrison, Nigel A, Forwood, Mark R., Mark R. Forwood   +5 more
core   +1 more source

Osteoclast Fusion and Fission [PDF]

Calcified Tissue International, 2012
Osteoclasts are specialized multinucleated cells with the unique capacity to resorb bone. Despite insight into the various steps of the interaction of osteoclast precursors leading to osteoclast formation, surprisingly little is known about what happens with the multinucleated cell itself after it has been formed.
Jansen, I.D.C., Vermeer, J.A.F., Bloemen, V., Stap, J., Everts, V.   +4 more
openaire   +7 more sources