Results 241 to 250 of about 130,158 (334)

A Retinoid Antagonist Attenuates Bone Growth Inhibition Caused by Growth Plate Injury in Mice

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Growth plate injury, which may trigger growth plate fusion or arrest, is a common occurrence in pediatric orthopaedics that can lead to angulation of the limb and limb length discrepancy. Growth plate injuries are currently treated palliatively, with surgical intervention when severe limb length discrepancy or angulation is found during follow‐
Masatake Matsuoka, Ningfeng Tang, Tian Hongying, Kenta Uchibe, Satoru Otsuru, Norimasa Iwasaki, Joshua M. Abzug, Motomi Enomoto‐Iwamoto, Masahiro Iwamoto   +8 more
wiley   +1 more source

Urolithin A Attenuates Periodontitis in Mice via Dual Anti-Inflammatory and Osteoclastogenesis Inhibition: A Natural Metabolite-Based Therapeutic Strategy. [PDF]

Molecules
Xia Y, Wu D, Zhou L, Wu X, Chen J.
europepmc   +1 more source

Osteogenic Small Molecule FK506 for Enhanced Bone Formation in a Rabbit Ankle Fusion Model

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Non‐union remains a significant complication following ankle fusion procedures, underscoring the need for effective osteogenic adjuvants to improve boney healing and fusion outcomes. This study investigates the osteogenic potential of FK506 (Tacrolimus), both in vitro and in vivo, for enhanced ankle fusion.
Nicholas Huffman, Amogh Magesh, Hanna Solomon, Caroline Dingler, Sreedhara Sangadala, Jay M. Patel, Jason T. Bariteau   +6 more
wiley   +1 more source

The inhibitory effects of 7ND protein on osteoclast differentiation in apical periodontitis. [PDF]

Front Cell Infect Microbiol
Ji ZZ, Xu XM, Lu YL, Zhang RZ, Zhang Y, Zou ZH, Xu Q.   +6 more
europepmc   +1 more source

COX‐2 in Fracture Callus Chondro‐Osseous Junction Osteoclasts Regulates Chondrocyte Hypertrophy and Callus Vasculogenesis

Journal of Orthopaedic Research, EarlyView.
ABSTRACT Cyclooxygenase‐2 (COX‐2) activity is necessary for bone fracture healing to proceed normally. COX‐2 is encoded by Ptgs2 and is expressed by several cell types during fracture healing, suggesting that COX‐2 regulates multiple processes to affect fracture healing.
Marc Teitelbaum, Hsuan‐Ni Lin, Maya D. Culbertson, Charlene Wetterstrand, J. Patrick O'Connor   +4 more
wiley   +1 more source

Epimedium Brevicornu and Curculigo orchioides inhibit osteoclast autophagy by degrading the level of miRNA-199 to regulate the mTOR signaling pathway. [PDF]

J Orthop Surg Res
Shi M, Sun P, Chai F.
europepmc   +1 more source

Metformin reverses periodontal destruction caused by experimental periodontitis by inhibiting interleukin‐1β activity

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis is a destructive disease that affects periodontal tissue. While current research focuses on disease management, research on tissue repair remains limited. Metformin, a first‐line medication for diabetes treatment, has positive effects on bone health in nondiabetic patients.
Zhao Wang, Ju Han Song, Jung‐Woo Kim, Seung‐Hee Kwon, Xianyu Piao, Sin‐Hye Oh, Suk‐Gyun Park, Sun‐Hun Kim, Je‐Hwang Ryu, Ok‐Su Kim, Jeong‐Tae Koh   +10 more
wiley   +1 more source

Targeting lipid raft-related stomatin to ameliorate osteoporosis in preclinical models. [PDF]

Nat Commun
Tao H, Chen K, Wang Q, Zhu P, Chu M, Chen W, Yang C, Gu Y, Yang H, Zhou Q, Lv S, Geng D.   +11 more
europepmc   +1 more source

Peri‐implant inflammation increases the risk of osteonecrosis in mice treated with bisphosphonate

Journal of Periodontology, EarlyView.
Abstract Background Bisphosphonates (BPs) are effective in managing bone diseases due to their anti‐resorptive properties but are linked to medication‐related osteonecrosis of the jaw (MRONJ), particularly concerning dental implants. This study explored the combined impact of ligature‐induced peri‐implant inflammation and zoledronic acid (ZA), a BP ...
Ana Bujila, Davi N. A. Silva, Sepehr Monajemzadeh, Taciane M. da Silveira, Naseim Elzakra, Maísa Casarin, Kimberly Flores, Clara Magyar, Julie Marchesan, Reuben Kim, Sotirios Tetradis, Flavia Q. Pirih   +11 more
wiley   +1 more source

An emerging role of mitochondrial quality control in bone metabolism: from molecular mechanisms to targeted therapeutic interventions. [PDF]

Cell Mol Life Sci
Qin Z, Zhu X, Shen Y, Ling H, Ruan N, Ye W, Xu Y, Gan X.   +7 more
europepmc   +1 more source