Complex dynamics of osteoclast formation and death in long-term cultures. [PDF]
PLoS ONE, 2008 BACKGROUND: Osteoclasts, cells responsible for bone resorption, contribute to the development of degenerative, metabolic and neoplastic bone diseases, which are often characterized by persistent changes in bone microenvironment.
Timur Akchurin +5 more
doaj +1 more source
Origin of Osteoclasts: Osteoclast Precursor Cells
Journal of Bone Metabolism, 2023 Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling for health and disease. Since the discovery of osteoclasts in 1873, the structure and function of osteoclasts and the molecular and cellular mechanisms of osteoclastogenesis have been extensively studied.
Jefferson Tsai +4 more
openaire +2 more sources
Biomolecules, 2022 Bone diseases such as osteoporosis are the result of osteoclast over-activation. There are many therapeutic agents from natural compounds inhibiting the formation of osteoclast that have been reported and are continuously being interested. Amygdalin (AD)
Nguyen Minh Trang +3 more
doaj +1 more source
Involvement of Noncoding RNAs in the Differentiation of Osteoclasts
Stem Cells International, 2020 As the most important bone-resorbing cells, osteoclasts play fundamental roles in bone remodeling and skeletal health. Much effort has been focused on identifying the regulators of osteoclast metabolism.
Yi Zhao +3 more
doaj +1 more source
BHLHE40 promotes osteoclastogenesis and abnormal bone resorption via c-Fos/NFATc1
Cell & Bioscience, 2022 Background Dysregulated osteoclast activity due to altered osteoclast differentiation causes multiple bone diseases. Osteoclasts are multinucleated giant cells derived from hematopoietic stem cells and play a major role in bone absorption.
Yufeng Zhang +10 more
doaj +1 more source
Retinoic acid increases proliferation of human osteoclast progenitors and inhibits RANKL-stimulated osteoclast differentiation by suppressing RANK. [PDF]
PLoS ONE, 2010 It has been shown that high vitamin A intake is associated with bone fragility and fractures in both animals and humans. However, the mechanism by which vitamin A affects bones is unclear. In the present study, the direct effects of retinoic acid (RA) on
Lijuan Hu +4 more
doaj +1 more source
Cellular and molecular mediators of bone metastatic lesions [PDF]
, 2018 Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia +3 more
core +5 more sources
The Cord Weekly (January 12, 1968) [PDF]
, 1968 Rab44 is an atypical Rab GTPase that contains some additional domains such as the EF-hand and coiled-coil domains as well as Rab-GTPase domain. Although Rab44 genes have been found in mammalian genomes, no studies concerning Rab44 have been reported yet.
山口, 優
core +3 more sources
Modulation of Osteoclast Interactions with Orthopaedic Biomaterials
Journal of Functional Biomaterials, 2018 Biomaterial integration in bone depends on bone remodelling at the bone-implant interface. Optimal balance of bone resorption by osteoclasts and bone deposition by osteoblasts is crucial for successful implantation, especially in orthopaedic surgery ...
Chris Steffi +3 more
doaj +1 more source
The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors. [PDF]
PLoS ONE, 2018 Inflammatory bone diseases, including rheumatoid arthritis, periodontitis and peri-implantitis, are associated not only with the production of inflammatory cytokines but also with local oxidative status, which is defined by intracellular reactive oxygen ...
Yoko Ohyama +4 more
doaj +1 more source