Results 21 to 30 of about 182,622 (382)
Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
Nature Communications, 2020 Wolff’s law and the Utah Paradigm of skeletal physiology state that bone architecture adapts to mechanical loads. These models predict the existence of a mechanostat that links strain induced by mechanical forces to skeletal remodeling.
Lijun Wang +5 more
semanticscholar +1 more source
Macrophage-Osteoclast Associations: Origin, Polarization, and Subgroups
Frontiers in Immunology, 2021 Cellular associations in the bone microenvironment are involved in modulating the balance between bone remodeling and resorption, which is necessary for maintaining a normal bone morphology.
Yang Sun +6 more
semanticscholar +1 more source
Biomolecules, 2022 Bone diseases such as osteoporosis are the result of osteoclast over-activation. There are many therapeutic agents from natural compounds inhibiting the formation of osteoclast that have been reported and are continuously being interested. Amygdalin (AD)
Nguyen Minh Trang +3 more
doaj +1 more source
Retinoic acid increases proliferation of human osteoclast progenitors and inhibits RANKL-stimulated osteoclast differentiation by suppressing RANK. [PDF]
PLoS ONE, 2010 It has been shown that high vitamin A intake is associated with bone fragility and fractures in both animals and humans. However, the mechanism by which vitamin A affects bones is unclear. In the present study, the direct effects of retinoic acid (RA) on
Lijuan Hu +4 more
doaj +1 more source
Involvement of Noncoding RNAs in the Differentiation of Osteoclasts
Stem Cells International, 2020 As the most important bone-resorbing cells, osteoclasts play fundamental roles in bone remodeling and skeletal health. Much effort has been focused on identifying the regulators of osteoclast metabolism.
Yi Zhao +3 more
doaj +1 more source
New Insights Into Osteoclast Biology
JBMR Plus, 2021 Osteoclasts are multinucleated cells that are characterized by their unique ability to resorb large quantities of bone. Therefore, they are frequently the target of therapeutic interventions to ameliorate bone loss.
M. McDonald +3 more
semanticscholar +1 more source
Cellular and molecular mediators of bone metastatic lesions [PDF]
, 2018 Bone is the preferential site of metastasis for breast and prostate tumor. Cancer cells establish a tight relationship with the host tissue, secreting factors that stimulate or inhibit bone cells, receiving signals generated from the bone remodeling ...
Battafarano, Giulia +3 more
core +5 more sources
Osteocyte-Related Cytokines Regulate Osteoclast Formation and Bone Resorption
International Journal of Molecular Sciences, 2020 The process of bone remodeling is the result of the regulated balance between bone cell populations, namely bone-forming osteoblasts, bone-resorbing osteoclasts, and the osteocyte, the mechanosensory cell type.
H. Kitaura +9 more
semanticscholar +1 more source
Cell Reports, 2020 Summary: Bone metabolism depends on the balance between osteoclast-driven bone resorption and osteoblast-mediated bone formation. Diseases like osteoporosis are characterized by increased bone destruction due to partially enhanced osteoclastogenesis ...
Yongxing Zhang +8 more
doaj +1 more source
The Cord Weekly (January 12, 1968) [PDF]
, 1968 Rab44 is an atypical Rab GTPase that contains some additional domains such as the EF-hand and coiled-coil domains as well as Rab-GTPase domain. Although Rab44 genes have been found in mammalian genomes, no studies concerning Rab44 have been reported yet.
山口, 優
core +3 more sources