Results 31 to 40 of about 182,622 (382)
Modulation of Osteoclast Interactions with Orthopaedic Biomaterials
Journal of Functional Biomaterials, 2018 Biomaterial integration in bone depends on bone remodelling at the bone-implant interface. Optimal balance of bone resorption by osteoclasts and bone deposition by osteoblasts is crucial for successful implantation, especially in orthopaedic surgery ...
Chris Steffi +3 more
doaj +1 more source
Regenerative Therapy, 2020 Objective: Nuclear factor-erythroid 2-related factor 2 (Nrf2) is shown to as a negative-regulatory cause in osteoclasts differentiation. Cannabinoid receptor type 2 (CB2) is verified to regulate osteoclast differentiation, though with diversed results ...
Wan Li, Yongxin Sun
doaj +1 more source
The polymethoxy flavonoid sudachitin suppresses inflammatory bone destruction by directly inhibiting osteoclastogenesis due to reduced ROS production and MAPK activation in osteoclast precursors. [PDF]
PLoS ONE, 2018 Inflammatory bone diseases, including rheumatoid arthritis, periodontitis and peri-implantitis, are associated not only with the production of inflammatory cytokines but also with local oxidative status, which is defined by intracellular reactive oxygen ...
Yoko Ohyama +4 more
doaj +1 more source
Life, 2022 (1) Background: Osteoporosis is a disease in which bones are weakened and fractured easily because of various factors. It is mainly observed in elderly and postmenopausal women, and it continues to carry high economic costs in aging societies.
Yongjin Lee +5 more
doaj +1 more source
Aplidin (plitidepsin) is a novel anti-myeloma agent with potent anti-resorptive activity mediated by direct effects on osteoclasts [PDF]
, 2019 Despite recent progress in its treatment, Multiple Myeloma (MM) remains incurable and its associated bone disease persists even after complete remission.
Atkinson, Emily G. +7 more
core +1 more source
Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro [PDF]
, 2013 Peer reviewedPublisher ...
Pappalardo, A., Thompson, K.
core +1 more source
Osteoclast Fusion and Fission [PDF]
Calcified Tissue International, 2012 Osteoclasts are specialized multinucleated cells with the unique capacity to resorb bone. Despite insight into the various steps of the interaction of osteoclast precursors leading to osteoclast formation, surprisingly little is known about what happens with the multinucleated cell itself after it has been formed.
Jansen, I.D.C. +4 more
openaire +10 more sources
International Journal of Molecular Sciences, 2019 Reactive oxygen species (ROS) and free radicals are essential for transmission of cell signals and other physiological functions. However, excessive amounts of ROS can cause cellular imbalance in reduction–oxidation reactions and disrupt normal ...
T. Agidigbi, Chaekyun Kim
semanticscholar +1 more source
Nature Communications, 2020 Bone remodeling consists of resorption by osteoclasts followed by formation by osteoblasts, and osteoclasts are a source of bone formation-stimulating factors.
Megan M. Weivoda +19 more
semanticscholar +1 more source
RAGE Signaling in Skeletal Biology [PDF]
, 2019 PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M. +2 more
core +1 more source