Results 31 to 40 of about 86,504 (190)

Effect of mitophagy in the formation of osteomorphs derived from osteoclasts

iScience, 2023
Summary: Osteoclasts are specialized multinucleated giant cells with unique bone-destroying capacities. A recent study revealed that osteoclasts undergo an alternative cell fate by dividing into daughter cells called osteomorphs. To date, no studies have
Tingben Huang, Yuchen Wang, Zhou Yu, Xiaoyan Miao, Zhiwei Jiang, Ke Yu, Mengdie Fu, Kaichen Lai, Ying Wang, Guoli Yang   +9 more
doaj   +1 more source

Diabetes Medication Metformin Inhibits Osteoclast Formation and Activity in In Vitro Models for Periodontitis

Frontiers in Cell and Developmental Biology, 2022
Diabetes and periodontitis are comorbidities and may share common pathways. Several reports indicate that diabetes medication metformin may be beneficial for the periodontal status of periodontitis patients.
Lucy Y. Tao, Lucy Y. Tao, Katarzyna B. Łagosz-Ćwik, Jolanda M.A. Hogervorst, Ton Schoenmaker, Aleksander M. Grabiec, Tim Forouzanfar, Fridus A. van der Weijden, Teun J. de Vries   +8 more
doaj   +1 more source

IgSF11-mediated phosphorylation of pyruvate kinase M2 regulates osteoclast differentiation and prevents pathological bone loss

Bone Research, 2023
Osteoclasts are primary bone-resorbing cells, and receptor-activated NF-kB ligand (RANKL) stimulation is the key driver of osteoclast differentiation.
Hyunsoo Kim, Noriko Takegahara, Yongwon Choi   +2 more
doaj   +1 more source

An inducible explant model of osteoclast-osteoprogenitor coordination in exacerbated osteoclastogenesis

iScience, 2023
Summary: Elucidating a basic blueprint of osteoclast-osteoblast coordination in skeletal remodeling and understanding how this coordination breaks down with age and disease is essential for addressing the growing skeletal health problem in our aging ...
Jarred M. Whitlock, Luis F. de Castro, Michael T. Collins, Leonid V. Chernomordik, Alison M. Boyce   +4 more
doaj   +1 more source

Endogenous Collagenases Regulate Osteoclast Fusion

Biomolecules, 2020
The precise regulation of osteoclast differentiation and function is crucial for the maintenance of healthy bone. Despite several reports of collagenase expression in bone tissues, the precise isoform expression as well as the role in osteoclasts are ...
Hyo Jeong Kim, Youngkyun Lee
doaj   +1 more source

TRAF-6 dependent signaling pathway is essential for TNF-related apoptosis-inducing ligand (TRAIL) induces osteoclast differentiation. [PDF]

PLoS ONE, 2012
Human osteoclast formation from mononuclear phagocyte precursors involves interactions between tumor necrosis factor (TNF) ligand superfamily members and their receptors. Recent evidence indicates that in addition to triggering apoptosis, the TNF-related
Men-Luh Yen, Ping-Ning Hsu, Hsiu-Jung Liao, Be-Hang Lee, Hwei-Fang Tsai   +4 more
doaj   +1 more source

Osteoclast-Derived Extracellular Vesicles: Novel Regulators of Osteoclastogenesis and Osteoclast–Osteoblasts Communication in Bone Remodeling

Frontiers in Physiology, 2018
Extracellular vesicles (EVs), including exosomes, microvesicles, and apoptotic bodies, play an important role in cellular communication during skeletal growth and homeostasis.
Feng-Lai Yuan, Qian-yuan Wu, Zong-Ning Miao, Ming-Hui Xu, Rui-Sheng Xu, Dong-Lin Jiang, Jun-Xing Ye, Fei-hu Chen, Ming-Dong Zhao, Hao-jue Wang, Xia Li   +10 more
doaj   +1 more source

Breast cancer cell-derived fibroblast growth factors enhance osteoclast activity and contribute to the formation of metastatic lesions. [PDF]

PLoS ONE, 2017
Fibroblast growth factors (FGFs) and their receptors (FGFRs) have been implicated in promoting breast cancer growth and progression. While the autocrine effects of FGFR activation in tumor cells have been extensively studied, little is known about the ...
Kelly Aukes, Cynthia Forsman, Nicholas J Brady, Kristina Astleford, Nicholas Blixt, Deepali Sachdev, Eric D Jensen, Kim C Mansky, Kathryn L Schwertfeger   +8 more
doaj   +1 more source

Inflammatory activation of the FcγR and IFNγR pathways co-influences the differentiation and activity of osteoclasts

Frontiers in Immunology, 2022
Osteoclasts are polykaryons formed by cell–cell fusion of highly motile progenitors of the myeloid lineage. Osteoclast activity can preserve skeletal strength and bone homeostasis.
Bettina Groetsch, Elisabeth Schachtschabel, Philipp Tripal, Benjamin Schmid, Ana-Suncana Smith, Georg Schett, Aline Bozec   +6 more
doaj   +1 more source

Osteoblast–osteoclast interactions [PDF]

Connective Tissue Research, 2017
Bone homeostasis depends on the resorption of bones by osteoclasts and formation of bones by the osteoblasts. Imbalance of this tightly coupled process can cause diseases such as osteoporosis. Thus, the mechanisms that regulate communication between osteoclasts and osteoblasts are critical to bone cell biology.
Xiao, Chen, Zhongqiu, Wang, Na, Duan, Guoying, Zhu, Edward M, Schwarz, Chao, Xie   +5 more
openaire   +2 more sources