Results 41 to 50 of about 182,622 (382)
Osteoclasts and hematopoiesis [PDF]
BoneKEy Reports, 2012 The skeletal tissue is closely associated with the hematopoietic tissue lodged in its inner cavities. Besides the well-known role of the endosteal osteoblasts in the maintenance of the hematopoietic stem cell (HSC) niche, it is an emerging concept that osteoclasts are involved in the regulation of hematopoiesis as well, although published data are ...
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From osteoblast to osteoclast: new insights of Yin-Yang theory in bone remodeling
World Journal of Traditional Chinese Medicine, 2015 Yin-Yang theory plays critical role in traditional Chinese medicine (TCM) science. However, there are many competing interpretations of Yin-Yang theory in the context with the development in biology, and no consensus has been established.
Dong-Feng Zhao +7 more
doaj +1 more source
Mechanisms by which sialylated milk oligosaccharides impact bone biology in a gnotobiotic mouse model of infant undernutrition [PDF]
, 2019 Undernutrition in children is a pressing global health problem, manifested in part by impaired linear growth (stunting). Current nutritional interventions have been largely ineffective in overcoming stunting, emphasizing the need to obtain better ...
Ahern, Philip P. +13 more
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Advances in the Regulation of Osteoclasts and Osteoclast Functions [PDF]
Journal of Dental Research, 2013 Osteoclasts are derived from mononuclear hematopoietic myeloid lineage cells, which are formed in the bone marrow and are attracted to the bloodstream by factors, including sphingsine-1 phosphate. These circulating precursors are attracted to bone surfaces undergoing resorption by chemokines and other factors expressed at these sites, where they fuse ...
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Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]
, 2017 Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran +15 more
core +2 more sources
Osteoclast Multinucleation: Review of Current Literature
International Journal of Molecular Sciences, 2020 Multinucleation is a hallmark of osteoclast maturation. The unique and dynamic multinucleation process not only increases cell size but causes functional alterations through reconstruction of the cytoskeleton, creating the actin ring and ruffled border ...
Joe Kodama, T. Kaito
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2020 Protein kinase C delta (PKC-δ) functions as an important regulator in bone metabolism. However, the precise involvement of PKC-δ in the regulation of osteoclasts remains elusive.
Shangfu Li +24 more
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Interleukin-20 Acts as a Promotor of Osteoclastogenesis and Orthodontic Tooth Movement
Stem Cells International, 2021 Objectives. Bones constitute organs that are engaged in constant self-remodelling. Osteoblast and osteoclast homeostasis during remodelling contribute to overall skeletal status.
Yuanbo Liu +10 more
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Calcium phosphate-based materials regulate osteoclast-mediated osseointegration
Bioactive Materials, 2021 Calcium phosphate-based materials (CaP) have been widely used as bone graft substitutes with a decent osseointegration. However, the mechanism whereby cells function and repair the bone defect in CaP micro-environment is still elusive.
Xiaogang Wang +5 more
doaj +1 more source
Science Translational Medicine, 2020 Independent of cathepsin K, the osteoclast-derived matrix metalloproteinases MMP9 and MMP14 codependently drive bone resorption. Codependent deconstruction Bone homeostasis encompasses a balancing act between formation of new bone and remodeling and ...
Lingxin Zhu +7 more
semanticscholar +1 more source