Results 41 to 50 of about 86,504 (190)

CD97 inhibits osteoclast differentiation via Rap1a/ERK pathway under compression

International Journal of Oral Science
Acceleration of tooth movement during orthodontic treatment is challenging, with osteoclast-mediated bone resorption on the compressive side being the rate-limiting step.
Wen Wang, Qian Wang, Shiying Sun, Pengfei Zhang, Yuyu Li, Weimin Lin, Qiwen Li, Xiao Zhang, Zhe Ma, Haiyan Lu   +9 more
doaj   +1 more source

The role of TRPV2 as a regulator on the osteoclast differentiation during orthodontic tooth movement in rats

Scientific Reports, 2023
When orthodontic forces are applied to teeth, bone remodeling, which consists of bone resorption and bone formation, occurs around the teeth. Transient receptor potential vanilloid 2 (TRPV2) is a cation channel expressed in various cell types that ...
Shohei Shigemi, Tadasu Sato, Mayuri Sakamoto, Takehiro Yajima, Takahiro Honda, Hiroka Tsumaki, Toru Deguchi, Hiroyuki Ichikawa, Tomohiro Fukunaga, Itaru Mizoguchi   +9 more
doaj   +1 more source

MicroRNA-34a prevents postmenopausal osteoporosis by promoting osteoclasts-induced osteoblasts differentiation and downregulating the proinflammatory cytokines [PDF]

, 2022
Wentao Lv, Xiaojie Chu, Zhonglei Bao, Xinyuan zhang, Jia Jia, Liyan Wang   +5 more
openalex   +1 more source

Osteoclast.

The Southern medical record
Citation: 'osteoclast' in the IUPAC Compendium of Chemical Terminology, 5th ed.; International Union of Pure and Applied Chemistry; 2025. Online version 5.0.0, 2025. 10.1351/goldbook.11050 • License: The IUPAC Gold Book is licensed under Creative Commons Attribution-ShareAlike CC BY-SA 4.0 International for individual terms.
Kapil Paiwal, Niranzena Panneer Selvam, Abrar Ahmed Alamoudi, Jitin Makker, Anirudha Agnihotry   +4 more
  +5 more sources

TAZ inhibits osteoclastogenesis by attenuating TAK1/NF-κB signaling

Bone Research, 2021
Osteoporosis is an osteolytic disorder commonly associated with excessive osteoclast formation. Transcriptional coactivator with PDZ-binding motif (TAZ) is a key downstream effector of the Hippo signaling pathway; it was suggested to be involved in the ...
Wanlei Yang, Xuanyuan Lu, Tan Zhang, Weiqi Han, Jianlei Li, Wei He, Yewei Jia, Kangxian Zhao, An Qin, Yu Qian   +9 more
doaj   +1 more source

Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton

eLife, 2022
Increased intracellular iron spurs mitochondrial biogenesis and respiration to satisfy high-energy demand during osteoclast differentiation and bone-resorbing activities.
Bhaba K Das, Lei Wang, Toshifumi Fujiwara, Jian Zhou, Nukhet Aykin-Burns, Kimberly J Krager, Renny Lan, Samuel G Mackintosh, Ricky Edmondson, Michael L Jennings, Xiaofang Wang, Jian Q Feng, Tomasa Barrientos, Jyoti Gogoi, Aarthi Kannan, Ling Gao, Weirong Xing, Subburaman Mohan, Haibo Zhao   +18 more
doaj   +1 more source

IL-17A deficiency inhibits lung cancer-induced osteoclastogenesis by promoting apoptosis of osteoclast precursor cells.

PLoS ONE
Osteoclasts are crucial in the events leading to bone metastasis of lung cancer. Interleukin-17A (IL-17A) affects osteogenesis by regulating the survival of osteoclast precursors (OCPs) and is enriched in lung cancer cells.
Hongkai Wang, Hao Tang, Shujie Yuan, Chuntao Liang, Yuanxin Li, Shida Zhu, Kai Chen   +6 more
doaj   +1 more source

Echinococcus granulosus sensu lato promotes osteoclast differentiation through DUSP4-MAPK signaling in osseous echinococcosis

Frontiers in Microbiology
IntroductionOsseous echinococcosis, caused by Echinococcus granulosus infection, is characterized by progressive bone destruction driven by abnormal osteoclast activation.
Haohao Sun, Yaqing Liu, Yaqing Liu, Yiping Huang, Kangjun Xiong, Zhendong Zhang, Weishan Wang, Yi Dai, Jing Li, Qi Li, Sibo Wang, Chenhui Shi   +11 more
doaj   +1 more source

Caspase-8 promotes scramblase-mediated phosphatidylserine exposure and fusion of osteoclast precursors

Bone Research
Efficient cellular fusion of mononuclear precursors is the prerequisite for the generation of fully functional multinucleated bone-resorbing osteoclasts.
Brenda Krishnacoumar, Martin Stenzel, Hilal Garibagaoglu, Yasunori Omata, Rachel L. Sworn, Thea Hofmann, Natacha Ipseiz, Magdalena A. Czubala, Ulrike Steffen, Antonio Maccataio, Cornelia Stoll, Christina Böhm, Martin Herrmann, Stefan Uderhardt, Robert H. Jenkins, Philip R. Taylor, Anika Grüneboom, Mario M. Zaiss, Georg Schett, Gerhard Krönke, Carina Scholtysek   +20 more
doaj   +1 more source

Periodontal ligament cells-derived exosomes promote osteoclast differentiation via modulating macrophage polarization

Scientific Reports
Several studies have demonstrated that exosomes (Exos) are involved in the regulation of macrophage polarization and osteoclast differentiation. However, the characteristics as well as roles of exosomes from human periodontal ligament cells (hPDLCs-Exos)
Xinyi Bai, Yingxue Wang, Xinyuan Ma, Yingying Yang, Cong Deng, Mengling Sun, Chen Lin, Linkun Zhang   +7 more
doaj   +1 more source