Results 51 to 60 of about 182,622 (382)
Frontiers in Pharmacology, 2020 Excessive bone resorption conducted by osteoclasts is considered as the main cause of osteoclast-related bone diseases such as osteoporosis. Therefore, the suppression of excessive osteoclast formation and function is one of the strategies to treat ...
Yu Yuan +15 more
doaj +1 more source
Arachidonic acid and docosahexaenoic acid suppress osteoclast formation and activity in human CD14+ monocytes, in vitro. [PDF]
PLoS ONE, 2015 An unbalanced diet can have adverse effects on health. Long chain polyunsaturated fatty acids (LCPUFAs) have been the focus of research owing to their necessity of inclusion in a healthy diet. However, the effects of LCPUFAs on human osteoclast formation
Abe E Kasonga +3 more
doaj +1 more source
Current Understanding of RANK Signaling in Osteoclast Differentiation and Maturation
Molecules and Cells, 2017 Osteoclasts are bone-resorbing cells that are derived from hematopoietic precursor cells and require macrophage-colony stimulating factor and receptor activator of nuclear factor-κB ligand (RANKL) for their survival, proliferation, differentiation, and ...
J. H. Park, N. Lee, Soo Young Lee
semanticscholar +1 more source
Journal of Clinical Investigation, 2020 Although the control of bone-resorbing osteoclasts through osteocyte-derived RANKL is well defined, little is known about the regulation of osteoclasts by osteocyte death.
D. Andreev +17 more
semanticscholar +1 more source
Myeloid DAP12-associating lectin (MDL)-1 regulates synovial inflammation and bone erosion associated with autoimmune arthritis. [PDF]
, 2010 DNAX adaptor protein 12 (DAP12) is a trans-membrane adaptor molecule that transduces activating signals in NK and myeloid cells. Absence of functional Dap12 results in osteoclast defects and bone abnormalities.
Adamopoulos, Iannis E +11 more
core +3 more sources
RhoA promotes osteoclastogenesis and regulates bone remodeling through mTOR-NFATc1 signaling
Molecular Medicine, 2023 Background The cytoskeletal architecture of osteoclasts (OCs) and bone resorption activity must be appropriately controlled for proper bone remodeling, which is associated with osteoporosis.
Jirong Wang +8 more
doaj +1 more source
SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts [PDF]
, 2017 Acknowledgements We sincerely thank the patients and family members who participated in this study. We would also like to thank Stefan Esher, Umeå University, for help with genealogy, and Anna Westerlund for excellent technical assistance.
Ameur, Adam +15 more
core +1 more source
BAP1 promotes osteoclast function by metabolic reprogramming
Nature Communications, 2023 Treatment of osteoporosis commonly diminishes osteoclast number which suppresses bone formation thus compromising fracture prevention. Bone formation is not suppressed, however, when bone degradation is reduced by retarding osteoclast functional ...
Nidhi Rohatgi +10 more
doaj +1 more source
Effect of mitophagy in the formation of osteomorphs derived from osteoclasts
iScience, 2023 Summary: Osteoclasts are specialized multinucleated giant cells with unique bone-destroying capacities. A recent study revealed that osteoclasts undergo an alternative cell fate by dividing into daughter cells called osteomorphs. To date, no studies have
Tingben Huang +9 more
doaj +1 more source
Regulation of Osteoclast Differentiation by Cytokine Networks
Immune Network, 2018 Cytokines play a pivotal role in maintaining bone homeostasis. Osteoclasts (OCs), the sole bone resorbing cells, are regulated by numerous cytokines. Macrophage colony-stimulating factor and receptor activator of NF-κB ligand play a central role in OC ...
Dulshara Sachini Amarasekara +5 more
semanticscholar +1 more source