Results 141 to 150 of about 919,707 (247)

Cysteine Peptidases in Antitumor Immunity: Unraveling Antigen‐Presenting Cell Regulation and Therapeutic Potential

iMetaMed, EarlyView.
This review systematically summarizes the central role of cysteine peptidases in modulating antigen‐presenting cell (APC) function and antitumor immune responses, highlighting their critical significance in overcoming tumor immune evasion. Current research has established that cysteine peptidase subtypes, including cathepsins B, S, L, and X, exert ...
Yimao Wu, Xiaoyan Chen, Zichang Chen, Yalun Liang, Gokhan Zengin, Qian Zhang, Wenlong Sun, Meng‐Yao Li   +7 more
wiley   +1 more source

Asarinin Inhibits RANKL-Induced Osteoclast Differentiation by Targeting the p38/ERK-c-Fos-NFATc1 Axis. [PDF]

Int J Mol Sci
Zhang L, Xie C, Bao X, Li X, Velez H, Basit F, Ding Y, Tabandeh M, Deepak V.   +8 more
europepmc   +1 more source

Human biomarker navigator

iMeta, EarlyView.
The Human Biomarker Navigator integrates the disease continuum, biomarker dynamics, cross‐organ biomarker networks, biomarker classification, and technology‐driven paradigms. It maps how biomarkers link multi‐system physiology and pathology across the nervous, respiratory, endocrine, circulatory, immune, digestive, urinary, reproductive, and ...
Meng‐Yao Li, Qian Zhang, Zijie Wang, Zeping Gui, Jing Liu, Jingda Li, Maojun Jiang, Zukang Chang, Qingqing Han, Bendong Yang, Tariq Saeed, Jun Li, Jinghan Jia, Chenghu Song, Tong Shao, Tianhuan Peng, Xueying Zhang, Pingping Guo, Jun Luo, Gangao Yang, Yuan Wan, Gokhan Zengin, Quan Yuan, Lingru Li, Xiaohui Fan, Yang Luo, Lvyun Zhu, Yanfei Zheng, Wenjun Mao, Wenlong Sun   +29 more
wiley   +1 more source

Exosomal Amphiregulin induce osteoclastogenesis through osteoclast differentiation mediated by EGFR pathway in NSCLC

, 2017
Exosomal Amphiregulin induce osteoclastogenesis through osteoclast differentiation mediated by EGFR pathway in ...
Marzia Pucci, Simona Taverna, Mariantonietta Di Bella, Christian Rolfo, Pablo Reclusa, Ignacio Gil Bazo I, Riccardo Alessandro   +6 more
core  

Vitamin K2 ameliorates pregnancy‐ and lactation‐associated osteopenia and postpartum depression

iMeta, EarlyView.
Vitamin K2 (VitK2) supplementation ameliorates comorbid pregnancy‐ and lactation‐associated osteopenia (PLO) and postpartum depression (PPD). These improvements are accompanied by reduced relative abundance of Bacteroides uniformis (B. uniformis) and lower serum deoxycholic acid (DCA) levels. DCA inhibits osteoblast differentiation, promotes osteoclast
Wanqiong Yuan, Jing Hang, Jialin Jia, Jie Huang, Xuanqi Zheng, Huan Wang, Tong Wu, Hao Liu, Junxiong Zhu, Chenggui Zhang, Jinwen He, Yundi Zhang, Hong Wang, Xin Xiong, Na He, Haofan Bai, Jiamin Yan, Huijie Leng, Weili Zhu, Yingsheng Xu, Jie Shi, Chunli Song   +21 more
wiley   +1 more source

Estradiol Enhances Alveolar Bone Resorption by Promoting Osteoclast Differentiation in Experimental Periodontitis. [PDF]

Dent J (Basel)
Yasuda K, Matsuda S, Memida T, Yoshimoto T, Nakashima F, Ninomiya Y, Ueda T, Shimada S, Hirata-Tsuchiya S, Kajiya M, Ouhara K, Mizuno N.   +11 more
europepmc   +1 more source

Expression of Capn6 During Osteoclast Differentiation In Wild-Type and Hdac4 Knockout Mice

, 2019
University of Minnesota M.S. thesis. 2019. Major: Dentistry. Advisor: Amy Tasca. 1 computer file (PDF); 38 pages.Introduction: The process of osteoclast differentiation consists of a network of complex signaling pathways.
Kopf, Molly
core  

ATP Citrate Lyase in Metabolic Disease: Mechanistic Insights and Clinical Potential

iNew Medicine, EarlyView.
ATP citrate lyase (ACLY) is a central metabolic hub that diverts mitochondrial citrate to fuel de novo lipogenesis, cholesterol biosynthesis, and protein acetylation. Given its robust correlation with pathological changes in multiple human diseases, ACLY inhibitors featuring distinct pharmacological strengths have been developed for therapeutic ...
Wenbiao Wang, Xinyan Li, Honglu Shi, Gaolei Song, Zhifu Xie, Jingya Li   +5 more
wiley   +1 more source

RUNX2 promotes osteoclast differentiation and bone resorption via the newly identified LncRNA-ROD: implications for alveolar remodeling. [PDF]

Int J Oral Sci
Li J, Liu Y, Qiao Y, Yan C, Zhao W, Ji L, Liu D, Xin Y, Zhang C, Wang X, Wang Y, Zheng S.   +11 more
europepmc   +1 more source

Peri‐implant disease pathogenesis animal models: Consensus report of Workgroup 1 of the IADR Implantology Research Group Best Evidence Consensus Symposium on Peri‐Implant Disease and Its Treatment

Journal of Periodontology, EarlyView.
Abstract Background The pathogenesis and etiology of peri‐implantitis demand a deeper understanding to lead to successful treatment modalities. Animal models of peri‐implantitis pathogenesis offer unique insights but their translational impact requires consideration of implant biomaterials science.
Georgios Kotsakis, Leonardo Mancini, Panos Afouxenides, Andrea Roccuzzo, IADR IRG Peri‐implantitis Best Evidence Consensus Working Group 1, Tara Aghaloo, Georgios Belibasakis, Nagihan Bostanci, Li Dehua, Nikolaos Donos, Alpdogan Kantarci, Alireza Moshaverinia, Flavia Pirih, Mia Rakic, Frank Schwarz, Sukirth Ganesan   +15 more
wiley   +1 more source