Results 191 to 200 of about 919,707 (247)

Teriparatide Topical Delivery Supports Osseointegration in Ovariectomized Rats Receiving Cafeteria Diet and Bisphosphonate: An In Vivo Experimental Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Background Postmenopausal osteoporosis associated with cafeteria diet and bisphosphonate therapy may impair peri‐implant bone repair. Therefore, strategies to enhance osseointegration are needed. Aim This study investigated whether teriparatide‐coated implant surfaces enhance osseointegration in a rodent model of estrogen deficiency (OVX) and ...
Ana Cláudia Ervolino da Silva, Fábio Roberto de Souza Batista, Jaqueline Suemi Hassumi, Naara Gabriela Monteiro, Marina Santos Fernandes, Luana Marotta Reis Vasconcellos, Gabriel Mulinari‐Santos, Reinhard Gruber, Paulo Noronha Lisboa‐Filho, Roberta Okamoto   +9 more
wiley   +1 more source

Egg Yolk-Derived Peptide VPF Orchestrates OPG/RANKL/RANK-Mediated Signaling to Suppress Osteoclast Differentiation and Facilitate Bone Development in Zebrafish. [PDF]

ACS Omega
Bao Z, Du J, Gao Y, Liu S, Xiao N, Wang H, Zhao L, Chen M, Feng F, Qu W, Wang Q.   +10 more
europepmc   +1 more source

Premature Occlusal Contacts Induce MRONJ in Osseointegrated Dental Implants: An Experimental In Vivo Study

Clinical Oral Implants Research, EarlyView.
ABSTRACT Objectives Medication‐related osteonecrosis of the jaw (MRONJ) is a debilitating condition associated with antiresorptive agents (ARAs) and can occur around well‐osseointegrated dental implants. Although implant presence–triggered osteonecrosis (IPTO) has been primarily linked to bacteria‐related peri‐implantitis, whether occlusal trauma ...
Eun‐Bin Bae, Ahana Goswami, Jun Yaung, Soo Yeon Kim, Sherry S. Baik, Kaylyn A. Yu, Chan Park, Jung‐Bo Huh, Jae‐Young Kim, Christine Y. Hong, Sol Kim, Reuben H. Kim   +11 more
wiley   +1 more source

Soluble Epoxide Hydrolase Inhibition Regulates Septoclast Activity to Promote Long Bone Growth and Fracture Healing by Enhancing Endothelial‐to‐Mesenchymal Notch Signalling

Cell Proliferation, EarlyView.
The sEH inhibitor TPPU upregulates endothelial HIF‐1α, activating the NOTCH signalling pathway between endothelial cells and mesenchymal stem cells. This promotes the differentiation and formation of FABP5+ septoclasts, enhances their participation in endochondral ossification, and ultimately improves longitudinal bone growth and fracture healing ...
Weixian Chen, Liangliang Liu, Xumeng Wang, Juanjuan Li, Jingyi Zhang, Xiaoli Shi, Qing Sun, Xu Chang, Jing Zhang, Jie Zhao, Fu Wang   +10 more
wiley   +1 more source

C-X-C motif chemokine ligand 13 suppresses osteoclast differentiation via interference with RANKL-RANK interaction. [PDF]

Front Immunol
Ho TL, Lee KT, He YH, Thuong LHH, Achudhan D, Huang WC, Ko CY, Liu CL, Guo JH, Tang CH.   +9 more
europepmc   +1 more source

Periodontitis‐Associated Circulating EVs Promote Colorectal Cancer Progression via Carnosine‐Mediated Acidosis Adaptation

Cell Proliferation, EarlyView.
This study identifies a link between periodontitis and CRC progression mediated by carnosine‐enriched circulating EVs. These EVs target the intestine and elevate tumour cell intracellular pH (pHi), which rescues lysosomal function. This process drives a transition from dysfunctional lysosomes to functional ones, promoting a high malignancy phenotype in
Ruoyi Wu, Zihan Cai, Hualing Sun, Haikun Yu, Bicheng Zhang, Chi Zhang, Yi Fan, Xiaoxuan Zhu, Yueqi Ni, Yu Cui, Kaixin Wang, Zhe Li, Xinyi Zhou, Qing He, Yanru Wu, Yufeng Zhang   +15 more
wiley   +1 more source

KAT6A regulates osteoclast differentiation and bone resorption through TET1-mediated TRPV4 expression. [PDF]

Naunyn Schmiedebergs Arch Pharmacol
Cao B, Dai X, Xiao L.
europepmc   +1 more source

Macrophage Lipid Homeostasis Drives IVDD via a Senescence‐Dependent Impairment of Efferocytosis

Cell Proliferation, EarlyView.
Intervertebral disc degeneration (IVDD) has been a leading cause of low back pain and lacks disease‐modifying therapies. Although dysregulated disc lipid metabolism is implicated, its impact on the immune microenvironment, particularly macrophages, remains unknown.
Jinyu Wang, Shiyong Ling, Qi Wang, Xuege Qiao, Jianpeng Xing, Siyang Ji, Linhui Han, Chen Yan, Zhishen Niu, Lei Yuan, Baolian Zhao, Kaiqiang Sun, Jiangang Shi   +12 more
wiley   +1 more source

Correction: "Betaone" barley water extract suppresses ovariectomy-induced osteoporosis in vivo and RANKL-induced osteoclast differentiation in vitro. [PDF]

PLoS One
Lee Y, Lee HJ, Kim KJ, Shin HB, Shin YA, Jin H, Ham JR, Choi SY, Lee MJ, Lee MK, Son YJ.   +10 more
europepmc   +1 more source