Results 211 to 220 of about 55,191 (264)
Some of the next articles are maybe not open access.
Osteoclast differentiation and activation
Nature, 2003Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis ...
William J, Boyle +2 more
openaire +2 more sources
Modulation of Osteoclast Differentiation
Endocrine Reviews, 1992I. Introduction BONE is a complex tissue in which resorption and formation continue throughout life. This process is called bone remodeling. Osteotropic hormones such as 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], PTH, and calcitonin preferentially modulate the process of bone resorption to maintain bone remodeling. The bone tissue contains various types
T, Suda, N, Takahashi, T J, Martin
openaire +2 more sources
Control of Osteoclast Differentiation
Critical Reviews in Eukaryotic Gene Expression, 1998The osteoclast is the primary bone-resorbing cell and is derived from the monocyte/macrophage lineage. Bipotent osteoclast precursors, which can form both osteoclasts and monocyte-macrophages, proliferate and differentiate to become unipotent post-mitotic committed osteoclast precursors.
S V, Reddy, G D, Roodman
openaire +2 more sources
The molecular understanding of osteoclast differentiation
Bone, 2007Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone matrix. The differentiation of osteoclasts is dependent on a tumor necrosis factor (TNF) family cytokine, receptor activator of nuclear factor (NF)-kappaB ligand (RANKL), as well as macrophage colony-stimulating factor (M-CSF).
Masataka, Asagiri, Hiroshi, Takayanagi
openaire +2 more sources
Modern Rheumatology, 2001
Abstract The aim of this study was to clarify the role of osteoclast differentiation factor (ODF) and osteoprotegerin (OPG) in synovial macrophage-osteoclast differentiation. Synovial macrophages were cultured in the presence of macrophage-colony-stimulating factor (M-CSF) and/or ODF. OPG was added to cocultures of synovial macrophages and UMR106.
O, Kudo +3 more
openaire +2 more sources
Abstract The aim of this study was to clarify the role of osteoclast differentiation factor (ODF) and osteoprotegerin (OPG) in synovial macrophage-osteoclast differentiation. Synovial macrophages were cultured in the presence of macrophage-colony-stimulating factor (M-CSF) and/or ODF. OPG was added to cocultures of synovial macrophages and UMR106.
O, Kudo +3 more
openaire +2 more sources
Osteoclast Differentiation Assay
2018Osteoclasts are highly specialized multinucleated cells derived from the monocyte/macrophage hematopoietic lineage that are uniquely capable of adhering to bone matrix and resorbing bone. The tartrate-resistant acid phosphatase (TRAP) assay is the most common method to detect osteoclasts population in vitro.
Jingxuan, Yang, Xiaohong, Bi, Min, Li
openaire +2 more sources
Epigenetic regulation of osteoclast differentiation
Annals of the New York Academy of Sciences, 2011Recent studies have uncovered that epigenetic regulation, such as histone methylation and acetylation, plays a critical role in determining cell fate. In particular, the expression of key developmental genes tends to be regulated by trimethylation of histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3).
Tetsuro, Yasui +3 more
openaire +2 more sources
Modulation of osteoclast differentiation by local factors
Bone, 1995Bone-resorbing osteoclasts are of hemopoietic cell origin, probably of the CFU-M-derived monocyte-macrophage family. Bone marrow-derived osteoblastic stromal cells play an important role in modulating the differentiation of osteoclast progenitors in two different ways: one is the production of soluble factors, and the other is cell-to-cell recognition ...
Toshio Suda +2 more
exaly +3 more sources
Interleukins in the Control of Osteoclast Differentiation
Critical Reviews in Eukaryotic Gene Expression, 1998To maintain homeostasis of bone, the production of osteoblasts and osteoclasts is tightly regulated. At the local level, hormones and cytokines control formation of osteoclasts from hemopoietic precursors by acting upon osteoblastic-stromal cells and in some cases also upon cells of the immune system.
T J, Martin, E, Romas, M T, Gillespie
openaire +2 more sources
A role for osteocalcin in osteoclast differentiation
Journal of Cellular Biochemistry, 1991AbstractSpecific cellular interactions with components of the extracellular matrix can influence cellular differentiation and development of many tissues. The extracellular matrix of bone is composed of organic constituents and a solid phase of calcium and inorganic phosphate (apatite).
J, Glowacki +4 more
openaire +2 more sources