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Resveratrol-Mediated Reversal of Doxorubicin-Induced Osteoclast Differentiation [PDF]
International Journal of Molecular Sciences, 2022 Secondary osteoporosis has been associated with cancer patients undertaking Doxorubicin (DOX) chemotherapy. However, the molecular mechanisms behind DOX-induced bone loss have not been elucidated. Molecules that can protect against the adverse effects of
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The molecular understanding of osteoclast differentiation
Bone, 2007Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone matrix. The differentiation of osteoclasts is dependent on a tumor necrosis factor (TNF) family cytokine, receptor activator of nuclear factor (NF)-kappaB ligand (RANKL), as well as macrophage colony-stimulating factor (M-CSF).
Masataka, Asagiri, Hiroshi, Takayanagi
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Modern Rheumatology, 2001
Abstract The aim of this study was to clarify the role of osteoclast differentiation factor (ODF) and osteoprotegerin (OPG) in synovial macrophage-osteoclast differentiation. Synovial macrophages were cultured in the presence of macrophage-colony-stimulating factor (M-CSF) and/or ODF. OPG was added to cocultures of synovial macrophages and UMR106.
O, Kudo +3 more
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Abstract The aim of this study was to clarify the role of osteoclast differentiation factor (ODF) and osteoprotegerin (OPG) in synovial macrophage-osteoclast differentiation. Synovial macrophages were cultured in the presence of macrophage-colony-stimulating factor (M-CSF) and/or ODF. OPG was added to cocultures of synovial macrophages and UMR106.
O, Kudo +3 more
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Osteoclast Differentiation Assay
2018Osteoclasts are highly specialized multinucleated cells derived from the monocyte/macrophage hematopoietic lineage that are uniquely capable of adhering to bone matrix and resorbing bone. The tartrate-resistant acid phosphatase (TRAP) assay is the most common method to detect osteoclasts population in vitro.
Jingxuan, Yang, Xiaohong, Bi, Min, Li
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Epigenetic regulation of osteoclast differentiation
Annals of the New York Academy of Sciences, 2011Recent studies have uncovered that epigenetic regulation, such as histone methylation and acetylation, plays a critical role in determining cell fate. In particular, the expression of key developmental genes tends to be regulated by trimethylation of histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3).
Tetsuro, Yasui +3 more
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Interleukins in the Control of Osteoclast Differentiation
Critical Reviews in Eukaryotic Gene Expression, 1998To maintain homeostasis of bone, the production of osteoblasts and osteoclasts is tightly regulated. At the local level, hormones and cytokines control formation of osteoclasts from hemopoietic precursors by acting upon osteoblastic-stromal cells and in some cases also upon cells of the immune system.
T J, Martin, E, Romas, M T, Gillespie
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A role for osteocalcin in osteoclast differentiation
Journal of Cellular Biochemistry, 1991AbstractSpecific cellular interactions with components of the extracellular matrix can influence cellular differentiation and development of many tissues. The extracellular matrix of bone is composed of organic constituents and a solid phase of calcium and inorganic phosphate (apatite).
J, Glowacki +4 more
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Regulation of Osteoclast Differentiation
Annals of the New York Academy of Sciences, 2006Abstract: The osteoclast (OCL) is derived from the cells in monocyte‐macrophage lineage. The earliest identifiable OCL precursor is the granulocyte‐macrophage colony‐forming unit (CFU‐GM), which gives rise to granulocytes, monocytes, and OCL. CFU‐GM–derived cells then differentiate to committed OCL precursors, which are post‐mitotic cells, and fuse ...
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MicroRNAs and their roles in osteoclast differentiation
Frontiers of Medicine, 2011Osteoclasts, which are derived from monocyte-macrophage precursors, are exclusive bone resorption cells. Limited evidence indicates that a class of small non-coding single-stranded RNAs known as "microRNAs" (miRNAs) is also involved in bone resorption.
Zhuying, Xia +4 more
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Osteoclast differentiation and gene regulation
Frontiers in Bioscience, 2007Osteoclasts, the bone resorbing cells, play a key role both in normal bone remodeling and in the skeletal osteopenia of arthritis, osteoporosis, periodontal disease and certain malignancies. Osteoclast cellular commitment, differentiation and function depend upon the establishment of specific patterns of gene expression achieved through networks of ...
Qingxiao, Zhao +3 more
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