Results 231 to 240 of about 55,191 (264)
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Differentiation, 2009
Survival and capability of cancer cells to form metastases fundamentally depend on interactions with their microenvironment. Secondary tumors originating from prostate carcinomas affect remodeling of bone tissue and can induce both osteolytic and osteocondensing lesions.
Petr, Vanhara +5 more
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Survival and capability of cancer cells to form metastases fundamentally depend on interactions with their microenvironment. Secondary tumors originating from prostate carcinomas affect remodeling of bone tissue and can induce both osteolytic and osteocondensing lesions.
Petr, Vanhara +5 more
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RANKL as the master regulator of osteoclast differentiation
Journal of Bone and Mineral Metabolism, 2021RANKL, the essential cue for osteoclast differentiation, is the membrane-bound factor expressed by osteoclastogenesis-supporting cells such as osteoblasts and osteocytes. In vivo evidence indicates that RANKL functions as the indispensable and irreplaceable in the program of osteoclast differentiation.
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Relaxin stimulates osteoclast differentiation and activation
Bone, 2010Relaxin is a pleiotropic hormone with actions in reproductive and non-reproductive tissues, and has a role in tumor biology. It can promote growth, differentiation and invasiveness of different tumors, especially those that give bone metastases, and relaxin serum concentrations are increased in patients with bone metastasis.
FERLIN, ALBERTO +4 more
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Macrophage Polarization and Osteoclast Differentiation
Macrophages are a key player to regulate rheumatoid arthritis pathogenesis from onset to remission. They can alter innate functions under microenvironmental conditions. To understand heterogeneous functions of macrophages in rheumatoid arthritis, several activated statuses of macrophages should be mimicked in vitro.Noritaka, Saeki, Akihiro, Nakata
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Osteoblast and Osteoclast Differentiation in Modeled Microgravity
Annals of the New York Academy of Sciences, 2007Abstract: Prolonged microgravity experienced by astronauts is associated with a decrease in bone mineral density. To investigate the effect of microgravity on differentiation of osteoclasts and osteoblasts, we used a NASA‐recommended, ground‐based, microgravity‐simulating system, the Rotary Cell Culture System (RCCS).
Ritu, Saxena +2 more
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Osteoclast: Origin and Differentiation
2005hydroxyapatite surface has led to a fuller understanding of this important cell. In this introductory chapter we set out the basic aspects of osteoclast origin and differentiation. Beginning with a description of the multinuclear cell found in bone and a brief introduction to its typing through functional characteristics, we discuss developing research
Janet Rubin, Edward M. Greenfield
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[Differentiation of osteoclasts].
Clinical calcium, 2005The differentiation and functions of osteoclasts (OCs) are regulated by osteoblast-derived factors such as receptor activator of NF kappa; B ligand (RANKL) that stimulates OC formation and a novel secreted member of the TNF receptor superfamily, osteoprotegerin (OPG), that negatively regulates osteoclastogenesis.
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[Osteoclast differentiation and activation].
Clinical calcium, 2007In autoimmune arthritis, activation of T cells induces bone destruction through receptor activator of NF-kappaB ligand (RANKL) . Recent study revealed interleukin-17 (IL-17) -producing helper T cell subset (Th17) , but not IFN-gamma-producing Th1, to be responsible for bone destruction.
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Osteoclast differentiation and activity
Biochemical Society Transactions, 1998openaire +2 more sources