Swiprosin-1 Negatively Regulates Osteoclast Differentiation and Bone Resorption via Akt/MAPK/NF-κB Pathway and αvβ3 Integrin-Dependent Signaling. [PDF]
Int J Mol SciCheon YH +5 more
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Targeted Dual Microdroplets for Modulating Osteoclast Differentiation and Function: A Novel Therapeutic Approach to Combat Osteoporosis. [PDF]
ACS Appl Mater InterfacesShi M +7 more
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Author Correction: Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation. [PDF]
Int J Oral SciRen F +7 more
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Fibroblast derived C3 promotes the progression of experimental periodontitis through macrophage M1 polarization and osteoclast differentiation. [PDF]
Int J Oral SciRen F +7 more
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Osteoclast differentiation and activation
Nature, 2003Osteoclasts are specialized cells derived from the monocyte/macrophage haematopoietic lineage that develop and adhere to bone matrix, then secrete acid and lytic enzymes that degrade it in a specialized, extracellular compartment. Discovery of the RANK signalling pathway in the osteoclast has provided insight into the mechanisms of osteoclastogenesis ...
William J, Boyle +2 more
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Regulation of Differentiated Osteoclasts
Critical Reviews in Eukaryotic Gene Expression, 2000Osteoclasts respond to many factors, including endocrines, cytokines, cell-cell interactions, and cell-matrix contacts. For mature osteoclasts, the first level of control occurs through signaling that follows binding to an appropriate substrate. Mononuclear and multinucleate osteoclasts are activated when cell surface integrins, notably but not ...
C V, Gay, J A, Weber
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Control of Osteoclast Differentiation
Critical Reviews in Eukaryotic Gene Expression, 1998The osteoclast is the primary bone-resorbing cell and is derived from the monocyte/macrophage lineage. Bipotent osteoclast precursors, which can form both osteoclasts and monocyte-macrophages, proliferate and differentiate to become unipotent post-mitotic committed osteoclast precursors.
S V, Reddy, G D, Roodman
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Modulation of Osteoclast Differentiation
Endocrine Reviews, 1992I. Introduction BONE is a complex tissue in which resorption and formation continue throughout life. This process is called bone remodeling. Osteotropic hormones such as 1α,25-dihydroxyvitamin D3 [1α,25(OH)2D3], PTH, and calcitonin preferentially modulate the process of bone resorption to maintain bone remodeling. The bone tissue contains various types
T, Suda, N, Takahashi, T J, Martin
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Abstract The aim of this study was to clarify the role of osteoclast differentiation factor (ODF) and osteoprotegerin (OPG) in synovial macrophage-osteoclast differentiation. Synovial macrophages were cultured in the presence of macrophage-colony-stimulating factor (M-CSF) and/or ODF. OPG was added to cocultures of synovial macrophages and UMR106.
O, Kudo +3 more
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Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function
Biochemical and Biophysical Research Communications, 2005Cancer-induced bone disease results in bone destruction, pathological fractures, and pain. We hypothesized that the inhibition of the proteasome-ubiquitin system in osteoclasts could abolish the receptor activator of NF-kappaB ligand (RANKL) mediated osteoclast differentiation and function, since RANKL-mediated downstream signaling plays a crucial role
Ivana, Zavrski +6 more
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