Results 261 to 270 of about 87,738 (302)
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Osteoclast Differentiation Assay
2018Osteoclasts are highly specialized multinucleated cells derived from the monocyte/macrophage hematopoietic lineage that are uniquely capable of adhering to bone matrix and resorbing bone. The tartrate-resistant acid phosphatase (TRAP) assay is the most common method to detect osteoclasts population in vitro.
Jingxuan, Yang, Xiaohong, Bi, Min, Li
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Epigenetic regulation of osteoclast differentiation
Annals of the New York Academy of Sciences, 2011Recent studies have uncovered that epigenetic regulation, such as histone methylation and acetylation, plays a critical role in determining cell fate. In particular, the expression of key developmental genes tends to be regulated by trimethylation of histone H3 lysine 4 (H3K4me3) and lysine 27 (H3K27me3).
Tetsuro, Yasui +3 more
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Osteoclast differentiation and gene regulation
Frontiers in Bioscience, 2007Osteoclasts, the bone resorbing cells, play a key role both in normal bone remodeling and in the skeletal osteopenia of arthritis, osteoporosis, periodontal disease and certain malignancies. Osteoclast cellular commitment, differentiation and function depend upon the establishment of specific patterns of gene expression achieved through networks of ...
Qingxiao, Zhao +3 more
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Regulation of Osteoclast Differentiation
Annals of the New York Academy of Sciences, 2006Abstract: The osteoclast (OCL) is derived from the cells in monocyte‐macrophage lineage. The earliest identifiable OCL precursor is the granulocyte‐macrophage colony‐forming unit (CFU‐GM), which gives rise to granulocytes, monocytes, and OCL. CFU‐GM–derived cells then differentiate to committed OCL precursors, which are post‐mitotic cells, and fuse ...
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MicroRNA-124 regulates osteoclast differentiation
Bone, 2013Osteoclasts are specialized cells for bone-resorption originated from precursors of macrophage/monocyte lineage. The receptor activator of NFκB ligand (RANKL) initiates osteoclast differentiation, in which nuclear factor of activated T cell cytoplasmic 1 (NFATc1) plays a key role as a master transcription factor.
Youngkyun, Lee +6 more
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Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis
Food and Chemical Toxicology, 2008In bone remodeling, an imbalance caused by increased bone resorption over bone formation leads to adult skeletal diseases such as osteoporosis. Therefore, the development of anti-resorptive agents has still gained more interest. In this study, using cell-based assay systems in RAW264.7 murine macrophage cells, we found that baicalein significantly ...
Myung Hee, Kim +5 more
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Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts
Journal of Cellular Physiology, 2009AbstractThe receptor activator of nuclear factor‐κB ligand (RANKL) plays a critical role in the differentiation and bone resorptive activity of osteoclasts. Recently, the development of anti‐resorptive agents from natural substances has become a subject of interest.
Myung Hee, Kim +4 more
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The molecular understanding of osteoclast differentiation
Bone, 2007Osteoclasts are multinucleated cells of monocyte/macrophage origin that degrade bone matrix. The differentiation of osteoclasts is dependent on a tumor necrosis factor (TNF) family cytokine, receptor activator of nuclear factor (NF)-kappaB ligand (RANKL), as well as macrophage colony-stimulating factor (M-CSF).
Masataka, Asagiri, Hiroshi, Takayanagi
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Malignant Melanoma With Osteoclast-Like Differentiation
International Journal of Surgical Pathology, 2015Osteoclast-like giant cells are frequently encountered in nonskeletal malignancies; however, the evidence to date suggests that they represent a tissue response to the lesion rather than neoplastic differentiation. We describe a case of metastatic melanoma demonstrating osteoclast-like differentiation in the lung.
Jason K, Wasserman +2 more
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Relaxin stimulates osteoclast differentiation and activation
Bone, 2010Relaxin is a pleiotropic hormone with actions in reproductive and non-reproductive tissues, and has a role in tumor biology. It can promote growth, differentiation and invasiveness of different tumors, especially those that give bone metastases, and relaxin serum concentrations are increased in patients with bone metastasis.
FERLIN, ALBERTO +4 more
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