Results 271 to 280 of about 87,738 (302)

New regulation mechanisms of osteoclast differentiation

Annals of the New York Academy of Sciences, 2011
Osteoclasts play a crucial role in both physiological and pathological bone resorption. It is, thus, of compelling importance to understand the molecular mechanisms of osteoclast regulation. Because receptor activator of nuclear factor‐κB ligand (RANKL) is the key cytokine that induces osteoclast differentiation, we have focused on the investigation of
Tomoki, Nakashima, Hiroshi, Takayanagi
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Heparin inhibits osteoclastic differentiation and function

Journal of Cellular Biochemistry, 2008
AbstractWe investigated the effects of Glycosaminoglycans (GAGs) on mouse monocytic cell line in regard to their differentiation, proliferation, and function in vitro. RAW 264.7 cells were cultured with receptor activator of NF‐κB ligand (RANKL) and various GAGs.
Wataru, Ariyoshi, Tetsu, Takahashi, Takahiro, Kanno, Hisashi, Ichimiya, Kouhei, Shinmyouzu, Hiroshi, Takano, Takeyoshi, Koseki, Tatsuji, Nishihara   +7 more
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Osteoclast Differentiation Factor Acts as a Multifunctional Regulator in Murine Osteoclast Differentiation and Function

The Journal of Immunology, 1999
Abstract Osteoclast differentiation factor (ODF), a novel member of the TNF ligand family, is expressed as a membrane-associated protein by osteoblasts/stromal cells. The soluble form of ODF (sODF) induces the differentiation of osteoclast precursors into osteoclasts in the presence of M-CSF.
E, Jimi, S, Akiyama, T, Tsurukai, N, Okahashi, K, Kobayashi, N, Udagawa, T, Nishihara, N, Takahashi, T, Suda   +8 more
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Growth/differentiation factor-15 inhibits differentiation into osteoclasts—A novel factor involved in control of osteoclast differentiation

Differentiation, 2009
Survival and capability of cancer cells to form metastases fundamentally depend on interactions with their microenvironment. Secondary tumors originating from prostate carcinomas affect remodeling of bone tissue and can induce both osteolytic and osteocondensing lesions.
Petr, Vanhara, Eva, Lincová, Alois, Kozubík, Pierre, Jurdic, Karel, Soucek, Jan, Smarda   +5 more
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Osteoclast: Origin and Differentiation

2005
hydroxyapatite surface has led to a fuller understanding of this important cell. In this introductory chapter we set out the basic aspects of osteoclast origin and differentiation. Beginning with a description of the multinuclear cell found in bone and a brief introduction to its typing through functional characteristics, we discuss developing research
Janet Rubin, Edward M. Greenfield
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Bone Cells Required for Osteoclastic Resorption but Not for Osteoclastic Differentiation

Biochemical and Biophysical Research Communications, 1996
It is generally considered that osteoblastic cells are essential for osteoclast formation. We tested the ability of hemopoietic tissue to differentiate osteoclastic characteristics in the absence of osteoblastic cells. We found that large numbers of calcitonin-receptor positive (CTRP) cells can be induced by prostaglandin E2 and 1,25(OH)2 vitamin D3 ...
J M, Owens, A C, Gallagher, T J, Chambers   +2 more
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Macrophage Polarization and Osteoclast Differentiation

Macrophages are a key player to regulate rheumatoid arthritis pathogenesis from onset to remission. They can alter innate functions under microenvironmental conditions. To understand heterogeneous functions of macrophages in rheumatoid arthritis, several activated statuses of macrophages should be mimicked in vitro.
Noritaka, Saeki, Akihiro, Nakata
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Advances in Osteoclast Differentiation and Function

Current Drug Targets - Immune, Endocrine & Metabolic Disorders, 2005
Osteoclasts are the sole bone resorbing cells. These cells are essential for skeletal development and remodeling throughout the life of animal and man. Deficiency of osteoclasts leads to osteopetrosis, a diseases manifested by increased non-remodeled bone mass, which ultimately leads to bone deformities and functional failure of other body systems.
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Fra-1 potentiates osteoclastic differentiation in osteoclast-macrophage precursor cell lines

Journal of Cellular Physiology, 1999
c-Fos, a component of the dimeric transcription factor AP-1, is necessary for osteoclast formation. To determine whether c-Fos can substitute for any or all of the stimuli needed for osteoclast induction, we infected osteoclast precursors with retroviral vectors expressing c-Fos or the Fos-related protein, Fra-1.
Owens, J.M., Matsuo, K., Nicholson, G.C., Wagner, E.F., Chambers, T.J.   +4 more
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[Differentiation of osteoclasts].

Clinical calcium, 2005
The differentiation and functions of osteoclasts (OCs) are regulated by osteoblast-derived factors such as receptor activator of NF kappa; B ligand (RANKL) that stimulates OC formation and a novel secreted member of the TNF receptor superfamily, osteoprotegerin (OPG), that negatively regulates osteoclastogenesis.
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