Results 221 to 230 of about 8,722 (259)

Bone Cells Required for Osteoclastic Resorption but Not for Osteoclastic Differentiation

Biochemical and Biophysical Research Communications, 1996
It is generally considered that osteoblastic cells are essential for osteoclast formation. We tested the ability of hemopoietic tissue to differentiate osteoclastic characteristics in the absence of osteoblastic cells. We found that large numbers of calcitonin-receptor positive (CTRP) cells can be induced by prostaglandin E2 and 1,25(OH)2 vitamin D3 ...
J M, Owens, A C, Gallagher, T J, Chambers   +2 more
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Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function

Biochemical and Biophysical Research Communications, 2005
Cancer-induced bone disease results in bone destruction, pathological fractures, and pain. We hypothesized that the inhibition of the proteasome-ubiquitin system in osteoclasts could abolish the receptor activator of NF-kappaB ligand (RANKL) mediated osteoclast differentiation and function, since RANKL-mediated downstream signaling plays a crucial role
Ivana, Zavrski, Holger, Krebbel, Britt, Wildemann, Ulrike, Heider, Martin, Kaiser, Kurt, Possinger, Orhan, Sezer   +6 more
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Osteoclast Differentiation Factor Acts as a Multifunctional Regulator in Murine Osteoclast Differentiation and Function

The Journal of Immunology, 1999
Abstract Osteoclast differentiation factor (ODF), a novel member of the TNF ligand family, is expressed as a membrane-associated protein by osteoblasts/stromal cells. The soluble form of ODF (sODF) induces the differentiation of osteoclast precursors into osteoclasts in the presence of M-CSF. Here, the effects of sODF on the survival,
E, Jimi, S, Akiyama, T, Tsurukai, N, Okahashi, K, Kobayashi, N, Udagawa, T, Nishihara, N, Takahashi, T, Suda   +8 more
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Regulation of the differentiation and function of osteoclasts

The Journal of Pathology, 2000
The osteoclast is the cell that resorbs bone. It has been known for many years that its formation and function are regulated by cells of the osteoblastic lineage. Recently the molecular basis for this regulation was identified; osteoblastic cells induce osteoclastic differentiation and resorptive activity through expression of tumour necrosis factor ...
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Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis

Food and Chemical Toxicology, 2008
In bone remodeling, an imbalance caused by increased bone resorption over bone formation leads to adult skeletal diseases such as osteoporosis. Therefore, the development of anti-resorptive agents has still gained more interest. In this study, using cell-based assay systems in RAW264.7 murine macrophage cells, we found that baicalein significantly ...
Myung Hee, Kim, Shi Yong, Ryu, Myung Ae, Bae, Joon-Sig, Choi, Yong Ki, Min, Seong Hwan, Kim   +5 more
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Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts

Journal of Cellular Physiology, 2009
AbstractThe receptor activator of nuclear factor‐κB ligand (RANKL) plays a critical role in the differentiation and bone resorptive activity of osteoclasts. Recently, the development of anti‐resorptive agents from natural substances has become a subject of interest.
Myung Hee, Kim, Shi Yong, Ryu, Joon Sig, Choi, Yong Ki, Min, Seong Hwan, Kim   +4 more
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Advances in Osteoclast Differentiation and Function

Current Drug Targets - Immune, Endocrine & Metabolic Disorders, 2005
Osteoclasts are the sole bone resorbing cells. These cells are essential for skeletal development and remodeling throughout the life of animal and man. Deficiency of osteoclasts leads to osteopetrosis, a diseases manifested by increased non-remodeled bone mass, which ultimately leads to bone deformities and functional failure of other body systems.
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Growth/differentiation factor-15 inhibits differentiation into osteoclasts—A novel factor involved in control of osteoclast differentiation

Differentiation, 2009
Survival and capability of cancer cells to form metastases fundamentally depend on interactions with their microenvironment. Secondary tumors originating from prostate carcinomas affect remodeling of bone tissue and can induce both osteolytic and osteocondensing lesions.
Petr, Vanhara, Eva, Lincová, Alois, Kozubík, Pierre, Jurdic, Karel, Soucek, Jan, Smarda   +5 more
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RANKL as the master regulator of osteoclast differentiation

Journal of Bone and Mineral Metabolism, 2021
RANKL, the essential cue for osteoclast differentiation, is the membrane-bound factor expressed by osteoclastogenesis-supporting cells such as osteoblasts and osteocytes. In vivo evidence indicates that RANKL functions as the indispensable and irreplaceable in the program of osteoclast differentiation.
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Relaxin stimulates osteoclast differentiation and activation

Bone, 2010
Relaxin is a pleiotropic hormone with actions in reproductive and non-reproductive tissues, and has a role in tumor biology. It can promote growth, differentiation and invasiveness of different tumors, especially those that give bone metastases, and relaxin serum concentrations are increased in patients with bone metastasis.
FERLIN, ALBERTO, PEPE A, FACCIOLLI A, GIANESELLO, LISA, FORESTA, CARLO   +4 more
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