Results 221 to 230 of about 55,191 (264)
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Regulation of Osteoclast Differentiation
Annals of the New York Academy of Sciences, 2006Abstract: The osteoclast (OCL) is derived from the cells in monocyte‐macrophage lineage. The earliest identifiable OCL precursor is the granulocyte‐macrophage colony‐forming unit (CFU‐GM), which gives rise to granulocytes, monocytes, and OCL. CFU‐GM–derived cells then differentiate to committed OCL precursors, which are post‐mitotic cells, and fuse ...
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MicroRNAs and their roles in osteoclast differentiation
Frontiers of Medicine, 2011Osteoclasts, which are derived from monocyte-macrophage precursors, are exclusive bone resorption cells. Limited evidence indicates that a class of small non-coding single-stranded RNAs known as "microRNAs" (miRNAs) is also involved in bone resorption.
Zhuying, Xia +4 more
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Osteoclast differentiation and gene regulation
Frontiers in Bioscience, 2007Osteoclasts, the bone resorbing cells, play a key role both in normal bone remodeling and in the skeletal osteopenia of arthritis, osteoporosis, periodontal disease and certain malignancies. Osteoclast cellular commitment, differentiation and function depend upon the establishment of specific patterns of gene expression achieved through networks of ...
Qingxiao, Zhao +3 more
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Bone Cells Required for Osteoclastic Resorption but Not for Osteoclastic Differentiation
Biochemical and Biophysical Research Communications, 1996It is generally considered that osteoblastic cells are essential for osteoclast formation. We tested the ability of hemopoietic tissue to differentiate osteoclastic characteristics in the absence of osteoblastic cells. We found that large numbers of calcitonin-receptor positive (CTRP) cells can be induced by prostaglandin E2 and 1,25(OH)2 vitamin D3 ...
J M, Owens +2 more
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Proteasome inhibitors abrogate osteoclast differentiation and osteoclast function
Biochemical and Biophysical Research Communications, 2005Cancer-induced bone disease results in bone destruction, pathological fractures, and pain. We hypothesized that the inhibition of the proteasome-ubiquitin system in osteoclasts could abolish the receptor activator of NF-kappaB ligand (RANKL) mediated osteoclast differentiation and function, since RANKL-mediated downstream signaling plays a crucial role
Ivana, Zavrski +6 more
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The Journal of Immunology, 1999
Abstract Osteoclast differentiation factor (ODF), a novel member of the TNF ligand family, is expressed as a membrane-associated protein by osteoblasts/stromal cells. The soluble form of ODF (sODF) induces the differentiation of osteoclast precursors into osteoclasts in the presence of M-CSF. Here, the effects of sODF on the survival,
E, Jimi +8 more
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Abstract Osteoclast differentiation factor (ODF), a novel member of the TNF ligand family, is expressed as a membrane-associated protein by osteoblasts/stromal cells. The soluble form of ODF (sODF) induces the differentiation of osteoclast precursors into osteoclasts in the presence of M-CSF. Here, the effects of sODF on the survival,
E, Jimi +8 more
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Regulation of the differentiation and function of osteoclasts
The Journal of Pathology, 2000The osteoclast is the cell that resorbs bone. It has been known for many years that its formation and function are regulated by cells of the osteoblastic lineage. Recently the molecular basis for this regulation was identified; osteoblastic cells induce osteoclastic differentiation and resorptive activity through expression of tumour necrosis factor ...
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Baicalein inhibits osteoclast differentiation and induces mature osteoclast apoptosis
Food and Chemical Toxicology, 2008In bone remodeling, an imbalance caused by increased bone resorption over bone formation leads to adult skeletal diseases such as osteoporosis. Therefore, the development of anti-resorptive agents has still gained more interest. In this study, using cell-based assay systems in RAW264.7 murine macrophage cells, we found that baicalein significantly ...
Myung Hee, Kim +5 more
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Saurolactam inhibits osteoclast differentiation and stimulates apoptosis of mature osteoclasts
Journal of Cellular Physiology, 2009AbstractThe receptor activator of nuclear factor‐κB ligand (RANKL) plays a critical role in the differentiation and bone resorptive activity of osteoclasts. Recently, the development of anti‐resorptive agents from natural substances has become a subject of interest.
Myung Hee, Kim +4 more
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Advances in Osteoclast Differentiation and Function
Current Drug Targets - Immune, Endocrine & Metabolic Disorders, 2005Osteoclasts are the sole bone resorbing cells. These cells are essential for skeletal development and remodeling throughout the life of animal and man. Deficiency of osteoclasts leads to osteopetrosis, a diseases manifested by increased non-remodeled bone mass, which ultimately leads to bone deformities and functional failure of other body systems.
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