Results 111 to 120 of about 36,147 (282)

PP2Ac Regulates Autophagy via Mediating mTORC1 and ULK1 During Osteoclastogenesis in the Subchondral Bone of Osteoarthritis

Advanced Science
The molecular mechanism underlying abnormal osteoclastogenesis triggering subchondral bone remodeling in osteoarthritis (OA) is still unclear. Here, single‐cell and bulk transcriptomics sequencing analyses are performed on GEO datasets to identify key ...
Haifeng Zhang, Gaoran Ge, Wei Zhang, Houyi Sun, Xiaolong Liang, Yu Xia, Jiacheng Du, Zerui Wu, Jiaxiang Bai, Huilin Yang, Xing Yang, Jun Zhou, Yaozeng Xu, Dechun Geng   +13 more
doaj   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

NFAT2 IS AN ESSENTIAL MEDIATOR OF ORTHOPEDIC PARTICLE-INDUCED OSTEOCLASTOGENESIS

, 2008
AuthorParticle-induced periprosthetic osteolysis is the major cause for orthopedic implant failure. This failure is mediated mainly by the action of osteoclasts, the principal cells responsible for bone resorption and osteolysis.
Otero, Jesse, Abu-Amer, Yousef, Foglia, Domenica, Abu-Amer, Wahid, ヤマナカ, ヤスヒロ, 山中, 康裕, Clohisy, John, Yamanaka, Yasuhiro   +7 more
core   +1 more source

Puerarin inhibits the migration of osteoclast precursors and osteoclastogenesis by inhibiting MCP-1 production

, 2020
Puerarin inhibits osteoclastogenesis and cells migration. This study aims to explore whether puerarin prevents osteoclastogenesis by inhibiting osteoclast precursors (OCPs) migration.
Xiaomin Fu (4470064), Yunlong Yu (1376577), Yinquan Lin (8555040), Dianshan Ke (8555037), Sanfu Lin (8555034)   +4 more
core   +1 more source

DataSheet3_Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.ZIP

, 2021
Receptor activator of nuclear factor-κB ligand (RANKL) has been found to induce osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms remain unclear.
Jing Sun (141206), Songtao Li (186776), Tongwei Chu (2926755), Xu Hu (23350), Jigong Wu (495850), Shangcheng Xu (533704), Hao Qiu (491130), Sizhen Yang (11475436), Wugui Chen (11492752), Ying Zhang (40767)   +9 more
core   +1 more source

KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL/OPG ratio on the compression side during orthodontic tooth movement

Progress in Orthodontics
Background Orthodontic tooth movement (OTM) is a dynamic equilibrium of bone remodeling, involving the osteogenesis of new bone and the osteoclastogenesis of old bone, which is mediated by mechanical force. Periodontal ligament stem cells (PDLCSs) in the
Kuang Tan, Jiayi Wang, Xinyu Su, Yunfei Zheng, Weiran Li   +4 more
doaj   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Disrupted joint clock is associated with rhythmic expression of bone destruction factors in collagen‐induced arthritis

Rheumatology &Autoimmunity, EarlyView.
Schematic Summary of Circadian Dysregulation in Arthritic Joints. This graphical abstract illustrates the key circadian disruptions observed in the collagen‑induced arthritis (CIA) model. The diagram depicts three main findings: (1) Nocturnal elevations in pro‑inflammatory cytokines (TNF‑α, IL‑6, IL‑17, IL‑1β, MIF) and bone‑destructive factors (DKK‑1 ...
Xiaogang Zhang, Mingming Zhang, Zhiqiang Wang, Jie Bai, Xing Feng, Yajing Wang, Zhenbin Li, Dongbao Zhao   +7 more
wiley   +1 more source

Table1_Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.docx

, 2021
Receptor activator of nuclear factor-κB ligand (RANKL) has been found to induce osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms remain unclear.
Jing Sun (141206), Songtao Li (186776), Tongwei Chu (2926755), Xu Hu (23350), Jigong Wu (495850), Shangcheng Xu (533704), Hao Qiu (491130), Sizhen Yang (11475436), Wugui Chen (11492752), Ying Zhang (40767)   +9 more
core   +1 more source

Hypoxia Exacerbates Periapical Periodontitis‐Associated Pathological Bone Loss via the Hypoxia‐Inducible Factor‐2α‐Calmodulin‐Dependent Protein Kinase IV Axis

Cell Proliferation, EarlyView.
Hypoxia exposure activates HIF‐2α, which binds to the Camk4 promoter to enhance RANKL‐mediated osteoclast differentiation, leading to aggravated alveolar bone resorption in periapical periodontitis. ABSTRACT Periapical periodontitis is one of the most common inflammatory bone destructive diseases. Epidemiological evidence suggests that hypoxia exposure,
Kang Gao, Yifan Xu, Haoran Du, Zixiao Li, Xiaochen Fang, Minghui Wang, Jia Liu, Xu Zha, Xianglong Han, Weihua Guo, Xicheng Liu, Jian Zhou   +11 more
wiley   +1 more source