Results 121 to 130 of about 29,684 (190)

Design and Manufacturing of Multifunctional Hydroxyapatite‐Coated Ti6Al4V Implants With Cissus quadrangularis

open access: yesJournal of Biomedical Materials Research Part A, Volume 114, Issue 8, August 2026.
ABSTRACT This study presents a novel approach to enhance the early‐stage osseointegration of orthopedic implants through surface engineering. Lithium (Li), strontium (Sr), and silver (Ag)‐doped hydroxyapatite (HA) were coated on Ti6Al4V substrates using RF induction based plasma spray coating and loaded with polydopamine (PD) and Cissus quadrangularis ...
Susmita Bose   +5 more
wiley   +1 more source

Selective Small‐Molecule AdipoR1 Agonist 3‐Hydroxy Pterocarpan Salt (CDRI‐1709S) Ameliorates Skeletal Muscle Atrophy

open access: yesJournal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 4, August 2026.
ABSTRACT Background Skeletal muscle atrophy is a frequent comorbidity of metabolic disorders and chronic diseases, and despite its high prevalence, no pharmacological therapy is available, representing a major unmet clinical need. Adiponectin and its receptors are key regulators of skeletal muscle metabolism, mitochondrial function and myogenesis, yet ...
Md. Rameez Moin   +12 more
wiley   +1 more source

Combined Effects of Puerarin and Adipose‐Derived Stem Cells on Alveolar Bone Preservation and Inflammation Control in Periodontitis Through p38MAPK Modulation

open access: yesThe Kaohsiung Journal of Medical Sciences, Volume 42, Issue 8, August 2026.
ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley   +1 more source

SIRT Family: Biological Functions and Therapeutic Targets

open access: yesMedComm, Volume 7, Issue 8, August 2026.
SIRT1–SIRT7 networks from transgenic mice to human‑relevant therapeutic targets. SIRT1–SIRT7 form an isoform‑, organ‑, and disease‑specific regulatory network. Transgenic Sirt1–7 mouse models define central regulatory SIRTs (SIRT1, SIRT3, SIRT6), context‑dependent modifiers (SIRT2, SIRT4, SIRT5, SIRT7), and their key mechanisms and target organs. These
Jia‐Yi Wang   +9 more
wiley   +1 more source

Ultrasound‐Driven Dual Piezocatalytic–Electrical Scaffold Synergistically Promotes Osteoporotic Bone Healing

open access: yesRare Metals, Volume 45, Issue 8, August 2026.
ABSTRACT The regeneration of osteoporotic bone defects is severely hampered by compromised endogenous healing capacity, demanding advanced strategies that actively orchestrate pro‐osteogenic microenvironments. Here, we report an integrated, self‐powered osteo‐regenerative system that uniquely leverages a dual ultrasound‐responsive piezoelectric ...
Bing Tan   +6 more
wiley   +1 more source

TTC26 scaffolds MINDY3-mediated RACK1 deubiquitination to drive osteoclastogenesis and pathological bone resorption. [PDF]

open access: yesJ Orthop Translat
Gao Y   +9 more
europepmc   +1 more source

Disruption of Claudin‐2 and Trpv6 Results in Hypocalcemia, Hypercalciuria, and Altered Bone Microarchitecture in Mice

open access: yesActa Physiologica, Volume 242, Issue 8, August 2026.
ABSTRACT Transepithelial calcium absorption occurs via a transcellular or paracellular pathway. The intestinal transcellular pathway relies, at least partially, on the apical calcium channel transient receptor potential vanilloid 6 (TRPV6), whereas paracellular calcium (re)absorption occurs through tight junction proteins, including claudin‐2 (CLDN2 ...
Harneet Kaur Bhullar   +6 more
wiley   +1 more source

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