Results 101 to 110 of about 53,100 (272)

Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study

Journal of Periodontology, EarlyView.
Abstract Background This study investigates the impact of disruptions in testosterone levels on bone remodeling, root resorption, and periodontal ligament (PDL) during orthodontic tooth movement (OTM) in a pubertal male rat model. Methods Testosterone deficiency was induced through orchiectomy, and the anabolic‐androgenic steroid (AAS, testosterone ...
Caio Luiz Bitencourt Reis, Kelly Galisteu‐Luiz, Gabriela Leite Pedroso, Gustavo Lopes Puls, Leticia Cassaro, Bruno Boaventura Vieira, Fábio Lourenço Romano, Erika Calvano Küchler, Christian Kirschneck, Daniela Silva Barroso de Oliveira, Maria Bernadete Sasso Stuani, Mirian Aiko Nakane Matsumoto   +11 more
wiley   +1 more source

Osteoclast differentiation from human blood precursors on biomimetic calcium-phosphate substrates [PDF]

, 2017
The design of synthetic bone grafts to foster bone formation is a challenge in regenerative medicine. Understanding the interaction of bone substitutes with osteoclasts is essential, since osteoclasts not only drive a timely resorption of the biomaterial,
Avnet, Sofia, Baldini, Nicola, Ciapetti, Gabriela, Díez Escudero, Anna, Ginebra Molins, Maria Pau, Martini, Desirée, Montufar Jiménez, Edgar Benjamin, Pompo, Gemma di   +7 more
core   +2 more sources

Combined Effects of Puerarin and Adipose‐Derived Stem Cells on Alveolar Bone Preservation and Inflammation Control in Periodontitis Through p38MAPK Modulation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley   +1 more source

The parasitic helminth product ES-62 suppresses pathogenesis in collagen-induced arthritis by targeting the interleukin-17–producing cellular network at multiple sites [PDF]

, 2012
Among many survival strategies, parasitic worms secrete molecules to modulate host immune responses. One such product, ES-62, is protective in the collagen-induced arthritis (CIA) model of rheumatoid arthritis.
Al-Riyami, Benderdour, Chu, Collins, Conti, Cooke, Fang, Feng, Goodridge, Goodridge, Goodridge, Gulen, Harnett, Harrington, Ito, Ivanov, Kelchtermans, Kenny, Koenders, Koshy, Kulkarni, Langrish, Lubberts, Marshall, Martin, McInnes, Murugaiyan, Nakae, Naor, Niedbala, Petermann, Pickens, Price, Reynolds, Roark, Sato, Shahrara, Shibata, Staschke, Sutton, Szanto, Takayanagi, Tanaka, Vermeire, Whelan, Xu, Xu, Yago   +47 more
core   +1 more source

Mesenchymal stromal cell therapy for rheumatoid arthritis: Long‐term efficacy, safety, and mechanistic insights

Rheumatology &Autoimmunity, EarlyView.
Graphical abstract summarizing the multifactorial pathogenesis of rheumatoid arthritis (RA) and the therapeutic potential of mesenchymal stromal cell (MSC) therapy. MSCs provide promising benefits through their immunomodulatory properties, low immunogenicity, ability to promote tissue repair, and multi‐lineage differentiation, presenting a potential ...
Yingjia Chen, Ruiyu Gao, Xing Guo, Genhong Yao, Xiaojun Tang, Yile E. Liu, Lingyun Sun   +6 more
wiley   +1 more source

Effect of lincRNA-EPS on osteoclastogenesis of RAW264.7 cells induced by RANKL and LPS: An experimental study

Kouqiang hemian waike zazhi
[Objective:] To study the effect of long non-coding RNA-EPS (lincRNA-EPS) on osteoclastogenesis of RAW264.7 cells induced by receptor activator for nuclear factor-κB ligand (RANKL) and lipopolysaccharide (LPS).
ZHANG Xu, WANG Yabing, SU Jiansheng
doaj   +1 more source

Is there a role for vitamin C in preventing osteoporosis and fractures?:A review of the potential underlying mechanisms and current epidemiological evidence [PDF]

, 2014
Osteoporosis and related fractures are a major global health issue, but there are few preventative strategies. Previously reported associations between higher intakes of fruits and vegetables and skeletal health have been suggested to be partly ...
Ailsa A. Welch, Amy Jennings, Andrew R. Hart, Bates, Bates, Canoy, Drewnowski, Gottlieb, Henriette Finck, Hill, Hoffer, Kaptoge, Lanham-New, Myllyla, New, New, Otsuka, Pradel, Prynne, Sahni, Scrimshaw, Sowers, Tucker, Wolf   +23 more
core   +1 more source

Harnessing energy metabolism for enhanced bone defect repair: Mechanisms and therapeutic strategies

VIEW, EarlyView.
This review addresses the critical challenge of bone defect repair by focusing on the underexplored role of cellular energy metabolism. It synthesizes regulatory mechanisms in bone‐forming cells and sums up innovative strategies—leveraging cell derivatives, active factors, and biomimetic scaffolds—to modulate metabolism for enhanced regeneration.
Junting Li, Yulan Liu, Yuran Li, Yingjie Hua, Xinquan Jiang, Mingliang Zhou   +5 more
wiley   +1 more source

PP2Ac Regulates Autophagy via Mediating mTORC1 and ULK1 During Osteoclastogenesis in the Subchondral Bone of Osteoarthritis

Advanced Science
The molecular mechanism underlying abnormal osteoclastogenesis triggering subchondral bone remodeling in osteoarthritis (OA) is still unclear. Here, single‐cell and bulk transcriptomics sequencing analyses are performed on GEO datasets to identify key ...
Haifeng Zhang, Gaoran Ge, Wei Zhang, Houyi Sun, Xiaolong Liang, Yu Xia, Jiacheng Du, Zerui Wu, Jiaxiang Bai, Huilin Yang, Xing Yang, Jun Zhou, Yaozeng Xu, Dechun Geng   +13 more
doaj   +1 more source

Role of galectin-3 in bone cell differentiation, bone pathophysiology and vascular osteogenesis [PDF]

, 2017
Galectin-3 is expressed in various tissues, including the bone, where it is considered a marker of chondrogenic and osteogenic cell lineages. Galectin-3 protein was found to be increased in the differentiated chondrocytes of the metaphyseal plate ...
Fantauzzi, Claudia Blasetti, Iacobini, Carla, Menini, Stefano, Pugliese, Giuseppe   +3 more
core   +2 more sources