Results 101 to 110 of about 36,147 (282)

Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro

, 2013
Peer ...
Thompson, K., A Pappalardo, Pappalardo, A., K Thompson   +3 more
core   +1 more source

Discontinuing Long‐Term Denosumab in Treating Fragile Bone: Why, for Whom, and How?

Clinical Pharmacology &Therapeutics, EarlyView.
Discontinuation of denosumab (Dmab) may be necessary due to adverse events or an unfavorable long‐term risk–benefit profile. However, accumulating evidence demonstrates pronounced rebound phenomena after withdrawal, most notably a marked increase in multiple vertebral fractures, and, in some reports, elevated mortality.
Ko‐Hsiu Lu, Renn‐Chia Lin, Ing‐Lin Chang, Shau‐Huai Fu, Meng‐Ying Tsai, Shun‐Fa Yang   +5 more
wiley   +1 more source

Hypoxia negatively affects senescence in osteoclasts and delays osteoclastogenesis [PDF]

, 2019
Cellular senescence, that is, the withdrawal from the cell cycle, combined with the acquirement of the senescence associated secretory phenotype has important roles during health and disease and is essential for tissue remodeling during embryonic ...
Korthagen, N., Miranda-Bedate, A., Nicoline Korthagen, de Bruin, A., Gorissen, Ben, René van Weeren, Tryfonidou, M.A., dES RMSC, Claudia Wolschrijn, Wolschrijn, C., Miranda-Bedate, Alberto, Teun J. de Vries, dCSCA RMSC-1, Alberto Miranda‐Bedate, dPB RMSC, de Vries, Teun J, Wolschrijn, Claudia, de Vries, T.J., van Weeren, R., Gorissen, B., Ben Gorissen, de Bruin, Alain, Marianna A. Tryfonidou, Tryfonidou, Marianna A, Regenerative Medicine, Stem Cells & Cancer, Korthagen, Nicoline, Alain de Bruin, van Weeren, René   +27 more
core   +1 more source

Effects of testosterone and high‐dose anabolic steroids on orthodontic‐induced bone remodeling and root resorption: An animal study

Journal of Periodontology, EarlyView.
Abstract Background This study investigates the impact of disruptions in testosterone levels on bone remodeling, root resorption, and periodontal ligament (PDL) during orthodontic tooth movement (OTM) in a pubertal male rat model. Methods Testosterone deficiency was induced through orchiectomy, and the anabolic‐androgenic steroid (AAS, testosterone ...
Caio Luiz Bitencourt Reis, Kelly Galisteu‐Luiz, Gabriela Leite Pedroso, Gustavo Lopes Puls, Leticia Cassaro, Bruno Boaventura Vieira, Fábio Lourenço Romano, Erika Calvano Küchler, Christian Kirschneck, Daniela Silva Barroso de Oliveira, Maria Bernadete Sasso Stuani, Mirian Aiko Nakane Matsumoto   +11 more
wiley   +1 more source

Impaired Osteoclastogenesis in Medication-Related Osteonecrosis and Potential Clinical Management with BMP-2

Medication-related osteonecrosis of the jaw (MRONJ) is a rare, but severe, complication of applying inhibitors of osteoclasts, specifically bisphosphonates and the monoclonal antibody of receptor activator of nuclear factor kappa-Β ligand (RANKL ...
Liu, Yuelian, Bakker, Astrid, Xu, Chunfeng, Xiao, Yin, Wu, Yiqun   +4 more
core   +1 more source

DataSheet2_Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.ZIP

, 2021
Receptor activator of nuclear factor-κB ligand (RANKL) has been found to induce osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms remain unclear.
Jing Sun (141206), Songtao Li (186776), Tongwei Chu (2926755), Xu Hu (23350), Jigong Wu (495850), Shangcheng Xu (533704), Hao Qiu (491130), Sizhen Yang (11475436), Wugui Chen (11492752), Ying Zhang (40767)   +9 more
core   +1 more source

Combined Effects of Puerarin and Adipose‐Derived Stem Cells on Alveolar Bone Preservation and Inflammation Control in Periodontitis Through p38MAPK Modulation

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT This study evaluated the effects of puerarin and adipose‐derived stem cells (ADSCs), alone or combined, on p38MAPK activity, alveolar bone preservation, and inflammatory responses in a rat periodontitis (PD) model and in vitro. ADSCs were exposed to various puerarin concentrations to assess cell proliferation, osteogenic differentiation, and ...
Ting Yang, Xu Zhang, Liang‐Fu Zhang
wiley   +1 more source

Effect of lincRNA-EPS on osteoclastogenesis of RAW264.7 cells induced by RANKL and LPS: An experimental study

Kouqiang hemian waike zazhi
[Objective:] To study the effect of long non-coding RNA-EPS (lincRNA-EPS) on osteoclastogenesis of RAW264.7 cells induced by receptor activator for nuclear factor-κB ligand (RANKL) and lipopolysaccharide (LPS).
ZHANG Xu, WANG Yabing, SU Jiansheng
doaj   +1 more source

Musculoskeletal Outcomes of Glucagon‐Like Peptide‐1 Receptor Agonists Versus Other Antiobesity Agents in Nondiabetic Adults

Obesity, EarlyView.
ABSTRACT Objective This study aimed to evaluate the association of glucagon‐like peptide‐1 receptor agonists (GLP‐1 RAs) with risks of osteoporosis, major osteoporotic fractures, and degenerative musculoskeletal disorders in nondiabetic adults with obesity compared with other obesity medications.
Jie‐Syuan Wu, Lee‐Yuan Lin, Jia‐Wei Sun, Wei‐Ting Yu, Fara Silvia Yuliani, Shyh‐Hsiang Lin   +5 more
wiley   +1 more source

DataSheet1_Nox4 Promotes RANKL-Induced Autophagy and Osteoclastogenesis via Activating ROS/PERK/eIF-2α/ATF4 Pathway.ZIP

, 2021
Receptor activator of nuclear factor-κB ligand (RANKL) has been found to induce osteoclastogenesis and bone resorption. However, the underlying molecular mechanisms remain unclear.
Jing Sun (141206), Songtao Li (186776), Tongwei Chu (2926755), Xu Hu (23350), Jigong Wu (495850), Shangcheng Xu (533704), Hao Qiu (491130), Sizhen Yang (11475436), Wugui Chen (11492752), Ying Zhang (40767)   +9 more
core   +1 more source