Results 81 to 90 of about 36,147 (282)

Parkin Inhibits RANKL-Induced Osteoclastogenesis and Ovariectomy-Induced Bone Loss

Biomolecules, 2022
Osteoporosis and osteoporotic fractures comprise a substantial health and socioeconomic burden. The leading cause of osteoporosis is an imbalance in bone formation and bone resorption caused by hyperactive osteoclasts.
Weiduo Hou, Mo Chen, Chenyi Ye, Erman Chen, Weixu Li, Wei Zhang   +5 more
doaj   +1 more source

Suppression of osteoclastogenesis by lactoferrin

Suppression of osteoclastogenesis by lactoferrin
Recent research has shown that lactoferrin indirectly suppresses osteoclastogenesis by affecting osteoblasts and periodontal ligament fibroblasts. However, the mechanism by which lactoferrin directly affects osteoclastogenesis is yet to be reported.
Suzuki, Kuniaki, Kato, Hiromichi, Yamazaki, Yutaka, Yoshimura, Yoshitaka, Minamikawa, Hajime   +4 more
openaire   +1 more source

Age-related decline in melatonin contributes to enhanced osteoclastogenesis via disruption of redox homeostasis

Molecular Medicine
Background Increased oxidative stress contributes to enhanced osteoclastogenesis and age-related bone loss. Melatonin (MT) is an endogenous antioxidant and declines with aging.
Di-Zheng Wu, Guo-Zheng Zhu, Kai Zhao, Jia-Wen Gao, Gui-Xing Cai, Hong-Zhou Li, Yu-Sheng Huang, Chen Tu, Jing-Shen Zhuang, Zhi-Wei Huang, Zhao-Ming Zhong   +10 more
doaj   +1 more source

Wedelolactone enhances osteoblastogenesis but inhibits osteoclastogenesis through Sema3A/NRP1/PlexinA1 pathway

Frontiers in Pharmacology, 2016
Bone remodeling balance is maintained by tight coupling of osteoblast-mediated bone formation and osteoclast-mediated bone resorption. Thus, agents with the capacity to regulate osteoblastogenesis and osteoclastogenesis have been investigated for therapy
Yanqiu Liu, Xiao fei Han, Jun xia Bo, Hui peng Ma   +3 more
doaj   +1 more source

Isoliquiritigenin Derivatives Inhibit RANKL-Induced Osteoclastogenesis by Regulating p38 and NF-κB Activation in RAW 264.7 Cells

Molecules, 2020
Bone diseases may not be imminently life-threatening or a leading cause of death such as heart diseases or cancers. However, as aging population grows in almost every part of the world, they surely impose significant socioeconomic burden on the society ...
Seongtae Jeong, Seahyoung Lee, Kundo Kim, Yunmi Lee, Jiyun Lee, Sena Oh, Jung-Won Choi, Sang Woo Kim, Ki-Chul Hwang, Soyeon Lim   +9 more
doaj   +1 more source

Inhibitory Effects of Astaxanthin on CML-HSA-Induced Inflammatory and RANKL-Induced Osteoclastogenic Gene Expression in RAW 264.7 Cells

Biomedicines, 2021
Objective: Elevated levels of serum Nε-carboxymethyllysine (CML), a well-known advanced glycation end-product (AGE), were observed in patients with inflammation or osteoporosis.
A. N. M. Mamun-Or-Rashid, Tanzima Tarannum Lucy, Masayuki Yagi, Yoshikazu Yonei   +3 more
doaj   +1 more source

Engineered Exosomal miR‐146a‐5p Reprograms BMSC Fate and Restores Mitochondrial Homeostasis in Glucocorticoid‐Induced Osteonecrosis of Femoral Head

Advanced Science, EarlyView.
Exosomal miR‐146a‐5p is identified as a pivotal regulator in steroid‐induced osteonecrosis. Its reduction activates NF‐κB signaling, compromises mitophagy, and disrupts mitochondrial bioenergetics, resulting in autophagic disequilibrium. Engineered exosomes delivering miR‐146a‐5p reinstate mitochondrial function, augment oxidative phosphorylation and ...
Zehui Lv, Xuejie Cai, Yiming Xu, Xingdong Yang, Ruoying Wang, Han Wang, Yixin Bian, Jiawei Xu, Jiao Lu, Lulu Liu, Yingjie Wang, Jibin Song, Bin Feng, Xisheng Weng   +13 more
wiley   +1 more source

Data_Sheet_1_Wnt7b Inhibits Osteoclastogenesis via AKT Activation and Glucose Metabolic Rewiring.docx

, 2021
The imbalance between bone formation and bone resorption causes osteoporosis, which leads to severe bone fractures. It is known that increases in osteoclast numbers and activities are the main reasons for increasing bone resorption.
Fanzi Wu (11736353), Xuchen Hu (4855723), Boer Li (11736356), Fanyuan Yu (5640554), Ling Ye (111749), Yu Shi (117923)   +5 more
core   +1 more source

LY3023414 inhibits both osteogenesis and osteoclastogenesis through the PI3K/Akt/GSK3 signalling pathway

Bone & Joint Research, 2021
Aims: LY3023414 is a novel oral phosphatidylinositol 3-kinase (PI3K)/mammalian target of rapamycin (mTOR) dual inhibitor designed for advanced cancers, for which a phase II clinical study was completed in March 2020; however, little is known about its ...
Xiaojun Chen, Wei Chen, Zin Mar Aung, Wenqing Han, Yan Zhang, Gang Chai   +5 more
doaj   +1 more source

Glycosaminoglycans modulate RANKL‐induced osteoclastogenesis [PDF]

Journal of Cellular Biochemistry, 2010
AbstractSkeletal integrity is tightly regulated by the activity of osteoblasts and osteoclasts that are both under the control of extracellular glycosaminoglycans (GAGs) through their interactions with endogenous growth factors and differentiation‐promoting ligands. Receptor activator of NF‐kappa‐B ligand (RANKL), which is a tumor necrosis factor (TNF)‐
Ling, Ling, Murali, Sadasivam, Stein, Gary S., Van Wijnen, Andre J., Cool, Simon M.   +4 more
openaire   +5 more sources