Results 81 to 90 of about 31,404 (249)

Integrative Genomic and Functional Investigation of the Multi‐Layered Genetic Architecture Between Anorexia Nervosa and Bone Loss

International Journal of Eating Disorders, EarlyView.
ABSTRACT Objective Bone loss is a severe and often irreversible complication of anorexia nervosa (AN), yet the genetic mechanisms underlying this comorbidity remain underexplored. This study focuses on constructing a comprehensive genetic architecture between AN and estimated calcaneal bone mineral density (eBMD).
Tao Han, Yuke Wang, Yixiong Dang, Rong Xiang, Yan Zeng, Sheng He, Ye Ju, Zilan Chen, Ting Liu, Zihao Li, Yuqi Pang, Wanyi Tan, Jue Xu, Jingwen Jiang, Xia Jiang   +14 more
wiley   +1 more source

KAT6A/YAP/TEAD4 pathway modulates osteoclastogenesis by regulating the RANKL/OPG ratio on the compression side during orthodontic tooth movement

Progress in Orthodontics
Background Orthodontic tooth movement (OTM) is a dynamic equilibrium of bone remodeling, involving the osteogenesis of new bone and the osteoclastogenesis of old bone, which is mediated by mechanical force. Periodontal ligament stem cells (PDLCSs) in the
Kuang Tan, Jiayi Wang, Xinyu Su, Yunfei Zheng, Weiran Li   +4 more
doaj   +1 more source

Severe skeletal fragility in SCN8A‐related developmental and epileptic encephalopathy

Epilepsia, EarlyView.
Abstract In this child with a phenotype compatible with the SCN8A gain‐of‐function spectrum, more than 20 bone fractures were documented. Together with previously reported cases, these observations raise the possibility that skeletal fragility may represent an underrecognized feature of the clinical spectrum associated with pathogenic SCN8A variants ...
Adélia Maria de Miranda Henriques‐Souza, Kette D. Valente   +1 more
wiley   +1 more source

Serum osteocalcin is associated with scintigraphic abnormalities in lame and clinically sound racehorses

Equine Veterinary Journal, EarlyView.
Abstract Background Musculoskeletal injury is a major welfare and economic challenge in racehorses, with stress‐related bone injury contributing to training interruption and catastrophic failure. Advanced imaging modalities can detect early skeletal pathology but remain limited in routine screening environments.
Peter Tually, Dominique Blache, Jack Meadows, Shiphrah Tagore, Paul O'Callaghan, Matilda Hathway, Ian Fulton, Geoffrey Currie   +7 more
wiley   +1 more source

Pu-erh Tea Extract Ameliorates Ovariectomy-Induced Osteoporosis in Rats and Suppresses Osteoclastogenesis In Vitro

Frontiers in Pharmacology, 2017
Background and Objective: Tea drinking is associated with positive effects on bone health and may protect against osteoporosis, especially in elderly women.
Titi Liu, Titi Liu, Titi Liu, Shihua Ding, Shihua Ding, Shihua Ding, Dan Yin, Dan Yin, Dan Yin, Xiangdan Cuan, Xiangdan Cuan, Xiangdan Cuan, Chuanqi Xie, Chuanqi Xie, Chuanqi Xie, Huanhuan Xu, Huanhuan Xu, Huanhuan Xu, Xuanjun Wang, Xuanjun Wang, Xuanjun Wang, Xuanjun Wang, Jun Sheng, Jun Sheng, Jun Sheng   +24 more
doaj   +1 more source

Pregnancy‐ and lactation‐associated osteoporosis: A position statement of the IAPM, IOF, ECTS, ESCEO, IMS, and EMAS

International Journal of Gynecology &Obstetrics, EarlyView.
Abstract Pregnancy‐ and lactation‐associated osteoporosis (PLO) is a syndrome characterized by fragility fractures (most commonly vertebral, often multiple) occurring in late pregnancy or the early postpartum period. This position statement summarizes the current knowledge of PLO, and the recommended procedure for assessment, diagnosis and treatment ...
Peyman Hadji, Apostolos Athanasiadis, Maria‐Luisa Brandi, Marlene Chakhtoura, Manju Chandran, Frank Chervenak, Amos Grünebaum, Irene Lambrinoudaki, Willem F. Lems, Apostolos M. Mamopoulos, Eugene McCloskey, Rossella E. Nappi, Jessica Pepe, Jean‐Yves Reginster, René Rizzoli, Petra Stute, Şansın Tuzun, Amanda J. Vincent, Maria Belen Zanchetta, M. Carola Zillikens, Ioannis Kyvernitakis   +20 more
wiley   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Adiponectin does not bind to gelatin: a new and easy way to purify high-molecular-weight adiponectin from human plasma

Journal of Lipid Research, 2010
Human plasma contains three forms of adiponectin, a trimer, a hexamer, and a high-molecular-weight (HMW) multimer. We previously reported HMW adiponectin was a gelatin-binding protein of 28 kDa (GBP28), it having been purified due to its affinity to ...
Yasuko Nakano, Ayako Shoji, Atsushi Arakawa, Yumiko Iizuka, Yuriko Kikuchi, Maya Kobayashi, Takashi Tobe   +6 more
doaj   +1 more source

MRI Proton Density Fat Fraction as a Biomarker of Marrow Recovery Following Organ‐Sparing Total Marrow Irradiation in Sickle Cell Disease

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Noninvasive quantitative assessment of marrow recovery after curative therapies such as total marrow irradiation (TMI) and bone marrow transplantation (BMT) remain poorly defined, particularly in sickle cell disease (SCD). Purpose To evaluate MRI‐derived proton density fat fraction (PDFF) as a biomarker of marrow recovery following ...
Malakeh Malekzadeh, Hemendra Ghimire, Ji Eun Lim, Srideshikan S. Madabushi, Weidong Hu, Marco Andrea Zampini, Kazuki Fujita, Raghda Fouda, Guy Storme, Joo Song, Bihong T. Chen, Anna Pawlowska, Susanta K. Hui   +12 more
wiley   +1 more source

Enterococcus faecalis immunoregulates osteoclastogenesis of macrophages

Experimental Cell Research, 2018
Persistent apical periodontitis (PAP) is characterized by refractory inflammation and progressive bone destruction. Enterococcus faecalis infection is considered an important etiological factor for the development of PAP, although the exact mechanisms remain unknown. This study aimed at investigating the role of E.
Neelakantan, P, Zhezhen, X, Yanling, C, Xi, W, Zhongchun, T   +4 more
openaire   +4 more sources