Results 161 to 170 of about 53,100 (272)

Chronic Alcohol Consumption Reprograms Osteoclast Lineage Communications to Promote Osteoclastogenesis. [PDF]

Biology (Basel)
Hemati H, Doratt BM, Messaoudi I.
europepmc   +1 more source

RNA Modifications: Current Understandings and Future Perspectives

MedComm, Volume 7, Issue 5, May 2026.
Types of RNA modification. We have summarized the currently common types of RNA modifications, including ac4C, m6A, m1A, m5C, m3C, m7G, and ψ, and visually characterized their features through structural formulas. The characteristic structures are marked with a background color different from the background color.
Shiyu Xiao, Tingwen Xiang, Chuan Yang, Xiaohua Wang, Gang Huang, Fei Luo, Zhao Xie, Yueqi Chen   +7 more
wiley   +1 more source

SIRT1 Downregulation by Advanced Glycation End Products Activates RANKL‐Dependent Osteoclast Signaling and Drives Chondrocyte Senescence During Osteoarthritis Development

Aging Cell, Volume 25, Issue 5, May 2026.
Mechanistic study of AGEs‐induced OA progression via SIRT1/RANKL/RANK signaling‐mediated osteoclast–chondrocyte communication and cellular senescence. ABSTRACT Advanced glycation end products (AGEs) accumulate with aging and metabolic stress and are increasingly implicated in osteoarthritis (OA) pathology.
Yizhou Li, Jian Wu, Rui Liu, Qiang Li, Fei Xue   +4 more
wiley   +1 more source

Nutrients and Metabolites as Signalling Molecules in Osteoclasts. [PDF]

Curr Osteoporos Rep
Chandrasekaran K, Hu S, Farstad-O'Halloran K, Iyer KS, Jiang H, Pavlos N, Chen K.   +6 more
europepmc   +1 more source

Repurposing Hetrombopag for Multiple Myeloma by Targeting PNPO: A Celastrol‐Inspired Approach

Basic &Clinical Pharmacology &Toxicology, Volume 138, Issue 5, May 2026.
Hetrombopag targeted PNPO to inhibit multiple myeloma. ABSTRACT Multiple myeloma (MM) is a malignancy of plasma cells whose excessive immunoglobulin production elevates reactive oxygen species (ROS), promoting pathogenesis. Active compounds from Traditional Chinese Medicine, such as celastrol, can exert antitumour effects by further increasing ROS ...
Tianyi Yu, Cheng Wang, Jingru Xie, Yongxin Wei, Hongwei Cui, Huaxia Zhang, Fan Zhou, Zhendong Deng, Ye Yang, Chunyan Gu   +9 more
wiley   +1 more source

Targeting innate immunity to modulate bone metabolism: a novel strategy for osteoporosis treatment. [PDF]

Front Aging
Kou W, Lu X, Zhang Z, Liu K, Liu Z, Jiang B, Wang H, Li J, Lu H, Guo C, Cao L, Zhang X.   +11 more
europepmc   +1 more source

ASXL1 impairs osteoclast formation by epigenetic regulation of NFATc1 [PDF]

, 2018
Abu-Amer, Yousef, Brestoff, Jonathan R., Chen, Timothy H., Collins, Patrick L., Rohatgi, Nidhi, Teitelbaum, Steven L., Zou, Wei   +6 more
core   +1 more source

Integrative Computational and Experimental Approaches Reveal the Protective Role of Moderate Caffeine Intake Against Apical Periodontitis Induced Bone Loss

International Endodontic Journal, Volume 59, Issue 5, Page 873-889, May 2026.
ABSTRACT Aim To investigate whether moderate systemic caffeine intake modulates the progression of apical periodontitis (AP) and associated alveolar bone loss, combining in vivo rat experiments with in silico molecular docking to explore potential mechanisms. Methodology Male Wistar rats were randomly assigned to four groups (n = 8 per group): control,
Matheus Ferreira Lima Rodrigues, Deborah Ribeiro Frazão, Deiweson Souza‐Monteiro, Vinicius Ruan Neves dos Santos, Felipe Oliveira Nunes, João Daniel Mendonça de Moura, Thamires Campos Gomes, Jorddy Neves Cruz, Cristiane do Socorro Ferraz Maia, Rodrigo A. Cunha, Fabrício Mezzomo Collares, Rogerio de Castilho Jacinto, Rafael Rodrigues Lima   +12 more
wiley   +1 more source

Optimizing <i>in vitro</i> osteoclastogenesis: bone marrow-derived macrophages differentiation and cell density as critical determinants. [PDF]

PeerJ
Li J, Sun X, Yan C, Zhao W, Liu D, Liu Y, Zheng S.   +6 more
europepmc   +1 more source

N‐Acetylcysteine Reduces Alveolar Bone Loss and Mitigates Systemic Oxidative Damage in Rats With Apical Periodontitis

International Endodontic Journal, Volume 59, Issue 5, Page 890-902, May 2026.
ABSTRACT Aim This study aimed to evaluate the effects of N‐acetylcysteine (NAC) supplementation in apical periodontitis (AP) induced in rats. Methodology Eighteen male Wistar rats were randomly assigned to three groups: control, AP, and AP plus NAC.
Ian Wesley Rocha dos Santos, Deiweson Souza‐Monteiro, Deborah Ribeiro Frazão, Zuleni Alexandre Lisboa da Silva, João Daniel Mendonça de Moura, Jorddy Neves Cruz, Fabrício Mezzomo Collares, Renata Duarte de Souza‐Rodrigues, Luciano Tavares Ângelo Cintra, Rafael Rodrigues Lima   +9 more
wiley   +1 more source