Results 151 to 160 of about 53,100 (272)

Elevated Circulating Ceramides 18:0 and 24:1 as a Risk Factor for Sarcopenia: In Vitro, Animal, and Clinical Evidence

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 3, June 2026.
ABSTRACT Background Ceramides have garnered considerable attention as pro‐aging bioactive lipids implicated in both metabolic dysfunction and musculoskeletal decline. Among these, C18:0 and C24:1 ceramides may play a role in the pathophysiology of sarcopenia, a key manifestation of age‐related deterioration.
So Jeong Park, Ji Yeon Baek, Shibo Wei, Jin Young Lee, Yuna Lee, Sang‐Hoon Lee, Il‐Young Jang, Hyuk Sakong, Hyun Ju Yoo, Hee‐Won Jung, Eunju Lee, Su Jung Kim, Yunju Jo, Kyunggon Kim, Dongryeol Ryu, Beom‐Jun Kim   +15 more
wiley   +1 more source

Myricitrin inhibits osteoclastogenesis

Journal of Orthopaedic Translation, 2016
Weiguang Lu, Liu Yang, Zhuojing Luo
openaire   +2 more sources

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, Volume 11, Issue 9, 6 May 2026.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

Advanced Materials Technologies, Volume 11, Issue 9, 6 May 2026.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang, He Huang, Hongliang Dong, Qiang Ma, Hongyan Jin   +4 more
wiley   +1 more source

Sirt3 Genetically Engineered Apoptotic Bodies Alleviate Skeletal Aging by Limiting Aggravated NLRP3 Inflammasome Activation of Senescent Macrophages

Advanced Science, Volume 13, Issue 26, 8 May 2026.
The senescence of macrophages leads to a decrease in the expression of Sirtuin3 (Sirt3), which in turn aggravates the NLRP3 inflammasome activation and IL‐1β secretion, thereby promoting the aging‐related osteoporosis. Sirt3‐enriched apoptotic bodies (ABs‐Sirt3) generated through genetic editing approaches can alleviate skeletal aging by targeting ...
Yanglin Wu, Shifeng Ling, Jiayi Mao, Hongyi Wang, Bo Wang, Zhenjia Che, Wenguo Cui, Ming Cai   +7 more
wiley   +1 more source

pH‐Shift‐Prepared Chlorella pyrenoidosa Protein/Peptide–Calcium Complexes Improve Skeletal Health by Enhanced Intestinal Calcium Utilization in Calcium‐Deficient Rats

Food Frontiers, Volume 7, Issue 3, May 2026.
ABSTRACT Calcium carbonate supplements often exhibit limited solubility and gastrointestinal precipitation, restricting calcium availability. To address this limitation, an enzyme‐free pH‐shift strategy was applied to prepare Chlorella pyrenoidosa protein (CPP)/peptide–calcium complexes (pH–Ca) and to evaluate their effects on calcium utilization in ...
Yan Yang, Shenwan Wang, Qimeng Zhou, Ye Qi, Bin Zhou, Jing Li, Tao Hou, Bin Li, Hongshan Liang   +8 more
wiley   +1 more source

Optimized Protocol for the Isolation of UHMWPE Wear Debris by Lyophilization and Chemometric Identification (EDS/PCA)

Journal of Biomedical Materials Research Part B: Applied Biomaterials, Volume 114, Issue 5, May 2026.
An optimized protocol combining serum lyophilization, solid‐state alkaline digestion, and PCA‐assisted EDS analysis was validated for the analysis of UHMWPE wear debris. The method increased recovery yield by 20‐fold compared to liquid digestion and preserved particle morphology.
Luis Antonio da Costa Bento, Vanessa Kapps, Rafael Mello Trommer, Bráulio Soares Archanjo, José Mauro Granjeiro, Marcia Marie Maru de Moraes   +5 more
wiley   +1 more source

Extracellular Vesicles in Osteoarthritis: From Pathogenic Mediators to Engineered Therapeutics in a Precision Medicine Roadmap

Journal of Extracellular Biology, Volume 5, Issue 5, May 2026.
ABSTRACT Osteoarthritis (OA) remains without disease‐modifying sssstherapies, in part due to biological heterogeneity and a hostile joint microenvironment that undermines one‐size‐fits‐all interventions. Extracellular vesicles (EVs) play a dual role in OA pathophysiology: endogenous EVs disseminate pro‐inflammatory and catabolic signals that propagate ...
Duc‐Hiep Bach, Van Giang Bui, Thanh Liem Nguyen   +2 more
wiley   +1 more source

Egg yolk hydrolysate shows moderate impact on osteoporosis in ovariectomized rats

Journal of the Science of Food and Agriculture, Volume 106, Issue 7, Page 4218-4227, May 2026.
Abstract BACKGROUND This study investigated the protective effect of egg yolk hydrolysate (FC) on osteoporosis in ovariectomized (OVX) rats, a well‐established model of postmenopausal bone loss. OVX rats were fed diets supplemented with 0.2% or 1% FC for 13 weeks.
Ilekuttige Priyan Shanura Fernando, Da Shi, Zihan Wang, Michael Doschak, Jianping Wu   +4 more
wiley   +1 more source

Melatonin Exerts Chondroprotective Effects Against Osteoarthritis by Promoting PI3K/AKT/FoxO3‐Mediated Mitophagy

The Kaohsiung Journal of Medical Sciences, Volume 42, Issue 5, May 2026.
ABSTRACT Osteoarthritis (OA) is a prevalent degenerative joint disease. This study combines bioinformatics analysis with in vivo and in vitro experiments to elucidate the molecular mechanisms through which melatonin (MT) regulates mitophagy to alleviate OA.
Chao Huang, Gang Zhang, Ying‐Kai Ma, Xin‐Nan Ma, Song‐Cen Lv   +4 more
wiley   +1 more source