Results 171 to 180 of about 31,404 (249)

From Virtual Modelling to Smarter Endodontic Innovation: In Silico Research for Translational Decision Making

International Endodontic Journal, Volume 59, Issue 11, Page 2464-2471, November 2026.
ABSTRACT Aim To discuss how in silico research may function as an early translational decision layer in endodontics by supporting the prioritisation of hypotheses, technologies and experimental conditions before biological and clinical validation. Summary Endodontic outcomes emerge from interacting anatomical, mechanical, chemical, microbial and host ...
José Evando da Silva‐Filho, Eduardo Diogo Gurgel‐Filho   +1 more
wiley   +1 more source

S100A9 Induces RANKL Expression in Osteocytes Utilizing IL‐6/sIL‐6R Combination and gp130 Signaling Pathways

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
S100A9 promotes osteocyte–macrophage crosstalk by inducing osteocyte‐derived IL‐6 and macrophage‐derived soluble IL‐6 receptor (sIL‐6R). The IL‐6/sIL‐6R complex activates gp130–JAK1–STAT3 signaling in osteocytes, enhancing RANKL expression and RANK‐mediated osteoclastogenesis.
Eijiro Sakamoto, Tetsuya Yoshimoto, Rie Kido, Mikihito Kajiya, Hiromichi Yumoto   +4 more
wiley   +1 more source

Higher Bone Mineral Density in Obesity Masks Impaired Bone Remodeling and Disproportionate Musculoskeletal Adaptation in Young Women

The FASEB Journal, Volume 40, Issue 20, 31 October 2026.
Women with obesity exhibited higher total and site‐specific BMD and greater lean mass than lean controls. However, reduced BMD‐to‐fat and lean‐to‐fat mass ratios, increased CTX1 and RANK‐L/OPG, and decreased P1NP and osteocalcin indicated impaired bone remodeling, suggesting that increased BMD masks altered bone turnover and compromised skeletal health.
Yasmin Silva Forte, Caio Andrade‐Santos, Camila Pantoja‐Marinho, Luísa González‐Joaquim, Aline Penna‐De‐Carvalho, Paulo Roberto Falcão Leal, Karynne Grutter Lopes, Luiz Guilherme Kraemer‐Aguiar, Christina Barja‐Fidalgo   +8 more
wiley   +1 more source

Osteoprotegerin and receptor activator of NF-kappaB ligand as biomarkers for bone resorption-related disorders. [PDF]

World J Exp Med
Lalotra T, Gunasekar A, Jeyaraman N, Nallakumarasamy A, Muthu S, Devanand V, Jeyaraman M.   +6 more
europepmc   +1 more source

Synthesis of β‐ and γ‐Carbolinones Through a Fe(III)‐Mediated Radical 6‐Endo‐Trig Cyclization of Indole‐Based Ugi 4‐CR Adducts

European Journal of Organic Chemistry, Volume 29, Issue 38, 13 October 2026.
A practical strategy for synthesizing β‐ and γ‐carbolinones from indole‐based Ugi 4‐CR adducts through an intramolecular radical cyclization using Fe(III)–H species is presented. This approach enables the efficient synthesis of spiro‐carbolinones under mild reaction conditions and demonstrates the effectiveness of secondary radicals in both cyclization
María F. Olvera‐Granados, Luis A. Polindara‐García   +1 more
wiley   +1 more source

Cytokine Regulation of the Bone Pre- and Metastatic Niches: Implications for Breast Cancer Dormancy. [PDF]

Cells
Clover TA, Price ML, Quayle LA, Le Maitre CL, Ottewell PD.   +4 more
europepmc   +1 more source

Local re-activation of osteoclast differentiation as a novel therapeutic strategy for osteonecrosis of the jaw

Frontiers in Endocrinology
Tommaso Zanocco-Marani, Silvia Ricchiuto, Lorenzo Caselli, Eleonora Lorenzi, Elia Lettucci, Alexis Grande   +5 more
doaj   +1 more source

MicroRNAs in osteoporosis: current evidence and clinical perspectives. [PDF]

Reumatologia
Świecka M, Chmielewski M.
europepmc   +1 more source