Results 1 to 10 of about 113,417 (358)

Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model [PDF]

Bone 50, 378-389 (2012), 2011
In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU). Our model takes into account the interaction of osteoclasts with the bone matrix, the interaction of osteoclasts with each other, the generation of osteoclasts from a growing blood vessel, and the ...
Anderson, Baron, Beysens, Block, Boyce, Boyde, Britz, Bronckers, Buenzli, Burger, Chambers, Civitelli, Cohen, Cooper, David W. Smith, Drasdo, Drasdo, Everts, Frost, Frost, Fukushima, García-Aznar, Gerlee, Ghaemi, Glauber, Glazier, Grynpas, Helfrich, Huang, Jaworski, Jeon, Junhwan Jeon, Manolagas, Mansury, Markus, Martin, Martin, Martin, Martin, Martin, Matsuoka, Miller, Mombach, Moshin, Nishiyama, Noble, Othmer, Othmer, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Pascal R. Buenzli, Peruani, Peter Pivonka, Peter T. Cummings, Poplawski, Robling, Roodman, Ryser, Schienbein, Schilling, Schweitzer, Stout, Susa, Tappen, van Kampen, van Oers, van Oers, Väänänen, Walker, Zhang   +74 more
arxiv   +4 more sources

Spatio-temporal structure of cell distribution in cortical Bone Multicellular Units: a mathematical model [PDF]

Bone 48 (2011) 918-926, 2010
Bone remodelling maintains the functionality of skeletal tissue by locally coordinating bone-resorbing cells (osteoclasts) and bone-forming cells (osteoblasts) in the form of Bone Multicellular Units (BMUs). Understanding the emergence of such structured units out of the complex network of biochemical interactions between bone cells is essential to ...
Bird, Bronckers, Buenzli, Burger, D.W. Smith, Evans, Frost, Frost, Gori, Halmos, Harada, Iqbal, Ishii, Ishii, Jaworski, Jaworski, Komarova, Lauffenburger, Lemaire, Martin, Martin, P. Pivonka, P.R. Buenzli, Parfitt, Parfitt, Parfitt, Pivonka, Roodman, Ryser, Ryser, Scheurer, Tang, Thomas, van Oers, Väänänen, Wolfram Research   +35 more
arxiv   +4 more sources

General analysis of mathematical models for bone remodeling [PDF]

arXiv, 2010
Bone remodeling is regulated by pathways controlling the interplay of osteoblasts and osteoclasts. In this work, we apply the method of generalized modelling to systematically analyse a large class of models of bone remodeling. Our analysis shows that osteoblast precursors can play an important role in the regulation of bone remodeling.
Gross, Thilo, Siegmund, Stefan, Stiefs, Dirk, Zumsande, Martin   +3 more
arxiv   +3 more sources

The Role of Osteocytes in Targeted Bone Remodeling: A Mathematical Model [PDF]

PLoS ONE 2013 May 22; 8(5): e63884, 2012
Until recently many studies of bone remodeling at the cellular level have focused on the behavior of mature osteoblasts and osteoclasts, and their respective precursor cells, with the role of osteocytes and bone lining cells left largely unexplored. This is particularly true with respect to the mathematical modeling of bone remodeling.
Ayati, Bruce P., Graham, Jason M., Holstein, Sarah A., Martin, James A.   +3 more
arxiv   +5 more sources

Towards a New Spatial Representation of Bone Remodeling [PDF]

, 2011
Irregular bone remodeling is associated with a number of bone diseases such as osteoporosis and multiple myeloma. Computational and mathematical modeling can aid in therapy and treatment as well as understanding fundamental biology. Different approaches to modeling give insight into different aspects of a phenomena so it is useful to have an arsenal ...
Ayati, Bruce P., Graham, Jason M., Martin, James A., Ramakrishnan, Prem S.   +3 more
arxiv   +5 more sources

Zoledronic acid promotes osteoclasts ferroptosis by inhibiting FBXO9-mediated p53 ubiquitination and degradation [PDF]

PeerJ, 2021
Bisphosphonates (BPs)-related osteonecrosis of jaw (BRONJ) is a severe complication of the long-term administration of BPs. The development of BRONJ is associated with the cell death of osteoclasts, but the underlying mechanism remains unclear.
Xingzhou Qu, Zhaoqi Sun, Yang Wang, Hui Shan Ong   +3 more
doaj   +2 more sources

Inhibitory Effects of Gold and Silver Nanoparticles on the Differentiation into Osteoclasts In Vitro

Pharmaceutics, 2021
Gold nanoparticles (GNPs) have been widely studied to inhibit differentiation into osteoclasts. However, reports of the inhibitory effects of silver nanoparticles (SNPs) during the process of differentiation into osteoclasts are rare.
Daye Lee, Wan-Kyu Ko, Seong Jun Kim, In-Bo Han, Je Beom Hong, Seung Hun Sheen, Seil Sohn   +6 more
doaj   +1 more source

Genetic ablation of CD68 results in mice with increased bone and dysfunctional osteoclasts. [PDF]

PLoS ONE, 2011
CD68 is a member of the lysosome associated membrane protein (LAMP) family that is restricted in its expression to cells of the monocyte/macrophage lineage. This lineage restriction includes osteoclasts, and, while previous studies of CD68 in macrophages
Jason W Ashley, Zhenqi Shi, Haibo Zhao, Xingsheng Li, Robert A Kesterson, Xu Feng   +5 more
doaj   +1 more source

A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups

Cells, 2022
Osteoclasts regulate skeletal development but also drive pathological osteolysis, making them prime therapeutic targets. Osteoclast research is limited by the heterogeneity of osteoclast populations generated in vitro, where the mixture of ...
Philippa A. Hulley, Helen J. Knowles
doaj   +1 more source

Ammonia-induced Calcium Phosphate Nanostructure: A Potential Assay for Studying Osteoporosis and Bone Metastasis [PDF]

ACS Applied Materials & Interfaces Manuscript ID: am-2021-004953.R2, 2021
Osteoclastic resorption of bone plays a central role in both osteoporosis and bone metastasis. A reliable in vitro assay that simulates osteoclastic resorption in vivo would significantly speed up the process of devel-oping effective therapeutic solutions for those diseases. Here we reported the development of a novel and robust nano-structured calcium
arxiv   +1 more source