Results 1 to 10 of about 66,646 (140)
USP8-mediated mitochondrial regulation in osteoclasts is essential for skeletal development [PDF]
Cellular and Molecular Life SciencesAberrant protein regulatory pathways disrupt bone development and contribute to skeletal diseases. The cysteine protease family of deubiquitinating enzymes (DUBs) are critical for regulation of bone-resorbing osteoclasts and bone-forming osteoblasts ...
Sachin Chaugule +4 more
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Osteoclasts and Microgravity [PDF]
Life, 2020 Astronauts are at risk of losing 1.0% to 1.5% of their bone mass for every month they spend in space despite their adherence to diets and exercise regimens designed to protect their musculoskeletal systems. This loss is the result of microgravity-related
John Kelly Smith
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Zoledronic acid promotes osteoclasts ferroptosis by inhibiting FBXO9-mediated p53 ubiquitination and degradation [PDF]
PeerJ, 2021 Bisphosphonates (BPs)-related osteonecrosis of jaw (BRONJ) is a severe complication of the long-term administration of BPs. The development of BRONJ is associated with the cell death of osteoclasts, but the underlying mechanism remains unclear.
Xingzhou Qu +3 more
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Inhibitory Effects of Gold and Silver Nanoparticles on the Differentiation into Osteoclasts In Vitro
Pharmaceutics, 2021 Gold nanoparticles (GNPs) have been widely studied to inhibit differentiation into osteoclasts. However, reports of the inhibitory effects of silver nanoparticles (SNPs) during the process of differentiation into osteoclasts are rare.
Daye Lee +6 more
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A New Method to Sort Differentiating Osteoclasts into Defined Homogeneous Subgroups
Cells, 2022 Osteoclasts regulate skeletal development but also drive pathological osteolysis, making them prime therapeutic targets. Osteoclast research is limited by the heterogeneity of osteoclast populations generated in vitro, where the mixture of ...
Philippa A. Hulley, Helen J. Knowles
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Immunological Medicine, 2022 Rheumatoid arthritis is a chronic form of arthritis that causes bone destruction in joints such as the knees and fingers. Over the past two decades, the clinical outcomes of rheumatoid arthritis have improved substantially with the development of ...
Tomoya Agemura +4 more
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Scientific Reports, 2021 Osteoclasts are multinucleated, bone-resorbing cells. However, they also digest cartilage during skeletal maintenance, development and in degradative conditions including osteoarthritis, rheumatoid arthritis and primary bone sarcoma.
Quitterie C. Larrouture +5 more
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Osteoclast activated FoxP3+ CD8+ T-cells suppress bone resorption in vitro. [PDF]
PLoS ONE, 2012 Osteoclasts are the body's sole bone resorbing cells. Cytokines produced by pro-inflammatory effector T-cells (T(EFF)) increase bone resorption by osteoclasts.
Zachary S Buchwald +4 more
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Origin of Osteoclasts: Osteoclast Precursor Cells
Journal of Bone Metabolism, 2023 Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling for health and disease. Since the discovery of osteoclasts in 1873, the structure and function of osteoclasts and the molecular and cellular mechanisms of osteoclastogenesis have been extensively studied.
Jefferson Tsai +4 more
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Stem Cell Research & Therapy, 2020 Background Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by non-functional osteoclasts and a fatal outcome early in childhood. About 50% of patients have mutations in the TCIRG1 gene.
Xiaojie Xian +7 more
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