Results 91 to 100 of about 132,467 (326)

MicroRNA-34a prevents postmenopausal osteoporosis by promoting osteoclasts-induced osteoblasts differentiation and downregulating the proinflammatory cytokines [PDF]

, 2022
Wentao Lv, Xiaojie Chu, Zhonglei Bao, Xinyuan zhang, Jia Jia, Liyan Wang   +5 more
openalex   +1 more source

Multiscale Bone Remodelling with Spatial P Systems [PDF]

, 2010
Many biological phenomena are inherently multiscale, i.e. they are characterized by interactions involving different spatial and temporal scales simultaneously.
A. Caiazzo, A. G. Hoekstra, A. G. Hoekstra, C.L. Penninger, C.S. Cowin, C.S. Cowin, D. C. Walker, D. Cacciagrano, D. Cacciagrano, D. J. W. Evans, Diletta Cacciagrano, Emanuela Merelli, F. Buti, Flavio Corradini, G. Marotti, G. Pv aun, Gabriel Ciobanu, H.M. Frost, J.L. Giavitto, J.V. Neumann, L. Cristofolini, Luca Tesei, M. G. Mullender, M. Woolridge, Maciej Koutny, P Systems web page, P. Prusinkiewicz, R. Barbuti, R. Fernandez, R. Huiskes, S. Harada, W. Kurth, W.J. Boyle   +32 more
core   +3 more sources

siRNA Delivery via Cross‐Linked Gelatin Microparticles Enables Targeted Modulation of Osteogenic‐Vascular Cross‐Talk: An Advanced Human 3D in Vitro Test System for Therapeutic siRNA

Advanced Healthcare Materials, EarlyView.
Osteogenic‐angiogenic cross‐talk is a vital prerequisite for vascularized bone regeneration. In this study, we investigated the effects of siRNA‐mediated silencing of two inhibitory proteins, Chordin and WWP‐1, via CaP‐NP‐loaded gelatin microparticles in osteogenically differentiated microtissues.
Franziska Mitrach, Jonas Kubat, Stefan Simm, Alexandra H. Springwald, Burak Demir, Anton Liebezeit, Michael C. Hacker, Michaela Schulz‐Siegmund   +7 more
wiley   +1 more source

Engineering approaches to manipulate osteoclast behavior for bone regeneration

Materials Today Bio
Extensive research has delved into the multifaceted roles of osteoclasts beyond their traditional function in bone resorption in recent years, uncovering their significant influence on bone formation.
Xin Cheng, Wenzhi Tian, Jianhua Yang, Jiamian Wang, Yang Zhang   +4 more
doaj   +1 more source

Sculpting the Future of Bone: The Evolution of Absorbable Materials in Orthopedics

Advanced Materials, EarlyView.
This review summarizes the current status of polymeric, ceramic, and metallic absorbable materials in orthopedic applications, and highlights several innovative strategies designed to enhance mechanical performance, control degradation, and promote bioactivity. We also discuss the progress and translational potential of absorbable materials in treating
Zhao Wang, Zehui Lv, Xuejie Cai, Yingjie Wang, Bo Peng, Haojing Xu, Hualuo Pang, Xingdong Yang, Jiawei Xu, Yixin Bian, Bin Feng, Peng Wen, Yufeng Zheng, Xisheng Weng   +13 more
wiley   +1 more source

Osteoclasts and hematopoiesis [PDF]

BoneKEy Reports, 2012
The skeletal tissue is closely associated with the hematopoietic tissue lodged in its inner cavities. Besides the well-known role of the endosteal osteoblasts in the maintenance of the hematopoietic stem cell (HSC) niche, it is an emerging concept that osteoclasts are involved in the regulation of hematopoiesis as well, although published data are ...
openaire   +3 more sources

3D Bioprinted Human Synovium‐Cartilage Models Mimic Rheumatoid Arthritis Microenvironment and Recapitulate In Vivo Therapeutic Responses

Advanced Materials, EarlyView.
This study presents human in vitro rheumatoid arthritis models using chondrocytes recellularized type II collagen scaffold and 3D‐bioprinted Gelatin‐Matrigel hydrogels with fibroblast‐like synoviocytes, pro‐inflammatory macrophages, and protective barrier macrophages, closely recapitulating key rheumatoid arthritis pathological features.
Huiqun Zhou, Zhen Zhang, Yulei Mu, Liang Ma, Xu Hu, Bangheng Liu, Dong‐An Wang   +6 more
wiley   +1 more source

Osteoclast differentiation in rheumatoid arthritis

Immunological Medicine
Osteoclasts, derived from the monocyte/macrophage line of bone marrow hematopoietic stem cell progenitors, are the sole bone-resorbing cells of the body.
Kazuhiro Yokota
doaj   +1 more source

Fabrication, Properties, and Applications of Scaffolds for Bone Tissue Regeneration

Advanced Materials Technologies, EarlyView.
This review explores cutting‐edge biomaterials and fabrication techniques for scaffolds in bone tissue regeneration. It conducts a critical comparison of various strategies, meticulously analyzes the key contradictions in the field, and outlines an integrated development path spanning from biomaterial selection to clinical application, while ...
Shangsi Chen, Min Wang
wiley   +1 more source

A novel method to efficiently differentiate human osteoclasts from blood-derived monocytes

Biological Procedures Online
Background Osteoclasts are the tissue-specific macrophage population of the bone and unique in their bone-resorbing activity. Hence, they are fundamental for bone physiology in health and disease.
Suganja Chandrabalan, Linh Dang, Uwe Hansen, Melanie Timmen, Corinna Wehmeyer, Richard Stange, Tim Beißbarth, Claudia Binder, Annalen Bleckmann, Kerstin Menck   +9 more
doaj   +1 more source