Results 111 to 120 of about 109,289 (351)
Cell Metabolism, 2009 Osteoclasts are the primary cells that resorb bone; they require high energy levels to degrade bone matrix, releasing minerals to maintain calcium homeostasis. Recent work on osteoclast differentiation and activity highlights an important role for mitochondrial biogenesis and explores the role of iron transferrin in generating a positive ...
G. David Roodman, G. David Roodman
openaire +3 more sources
A RANKL-PKCβ-TFEB signaling cascade is necessary for lysosomal biogenesis in osteoclasts.
Genes & Development, 2013 Bone resorption by osteoclasts requires a large number of lysosomes that release proteases in the resorption lacuna. Whether lysosomal biogenesis is a consequence of the action of transcriptional regulators of osteoclast differentiation or is under the ...
Mathieu Ferron +7 more
semanticscholar +1 more source
Current Advances of Antibacterial Biomaterials for Bone Regeneration
Advanced Materials Interfaces, EarlyView.Effective treatment of infectious bone defects requires not only robust bone regeneration, but also the elimination of bacterial infection. This review highlights current cutting‐edge concepts and innovations in synthetic bone repair biomaterials and antibacterial bone repair materials, aiming to promote clinical translation and inspire broader ...
Xueping Kong +3 more
wiley +1 more source
RAGE Signaling in Skeletal Biology [PDF]
, 2019 PURPOSE OF REVIEW: The receptor for advanced glycation end products (RAGE) and several of its ligands have been implicated in the onset and progression of pathologies associated with aging, chronic inflammation, and cellular stress. In particular, the
Davis, Hannah M. +2 more
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Osteoimmunology and the influence of pro-inflammatory cytokines on osteoclasts
Biochemia Medica, 2013 Bone and immune system are functionally interconnected. Immune and bone cells derive from same progenitors in the bone marrow, they share a common microenvironment and are being influenced by similar mediators.
J. Zupan, M. Jeras, J. Marc
semanticscholar +1 more source
Accelerated Bone Healing via Electrical Stimulation
Advanced Science, EarlyView.Electrical stimulation significantly impacts bone healing by enhancing osteoblast proliferation, differentiation, and vascularization through calmodulin/calcineurin/NFAT signaling. It also boosts macrophage function and cell migration, presenting a comprehensive approach to accelerating bone repair.
Jianfeng Sun +4 more
wiley +1 more source
INTRAVASCULAR OSTEOCLASTS [PDF]
The Journal of Bone and Joint Surgery. British volume, 1957 1. In five out of eleven cases of osteoclastoma it was found that osteoclasts were present inside clearly defined blood vessels either within the tumours or in the tissues immediately surrounding the tumours. In two further cases it was found that osteoclasts protruded into the vessels although they were not lying free within the vessels. 2.
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Recent Advancements in Lung Cancer Metastasis Prevention Based on Nanostrategies
Advanced Science, EarlyView.Metastasis is the leading cause of death in patients with lung cancer. Nanomedicine can be used to prepare efficient drug delivery systems owing to their advantages and plays an important role in the synergistic antimetastasis of lung cancer. This comprehensive review summarizes the emerging nanostrategies against lung cancer metastasis based on the ...
Fan Xu +7 more
wiley +1 more source
The Direct Effect of Low-Magnitude High-Frequency Mechanical Vibration on Osteoclast Formation from RAW267.4 Monocytes [PDF]
, 2015 Low-magnitude high-frequency (LMHF) mechanical vibration has been demonstrated to enhance bone formation possibly through inhibition of osteoclastogenesis of bone.
Abraham, Maxwell Antonio
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Osteoclasts: what do they do and how do they do it?
American Journal of Pathology, 2007 As Americans live longer, degenerative skeletal diseases, such as osteoporosis, become increasingly prevalent. Regardless of cause, osteoporosis reflects a relative enhancement of osteoclast activity. Thus, this unique bone resorptive cell is a prominent
S. Teitelbaum
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