Results 11 to 20 of about 109,289 (351)
Advances in the Regulation of Osteoclasts and Osteoclast Functions [PDF]
Journal of Dental Research, 2013 Osteoclasts are derived from mononuclear hematopoietic myeloid lineage cells, which are formed in the bone marrow and are attracted to the bloodstream by factors, including sphingsine-1 phosphate. These circulating precursors are attracted to bone surfaces undergoing resorption by chemokines and other factors expressed at these sites, where they fuse ...
B. Boyce
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Generation and culture of osteoclasts [PDF]
BoneKEy Reports, 2014 Osteoclasts are highly specialized cells of haematopoietic lineage that are uniquely responsible for bone resorption. In the past, osteoclasts were isolated as mature cells from chicken long bones, or were generated using osteoblasts or stromal cells to induce osteoclast formation in total bone marrow from mice or rabbits.
Marino, S +3 more
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Osteoclasts in multiple myeloma are derived from Gr-1+CD11b+myeloid-derived suppressor cells. [PDF]
PLoS ONE, 2012 Osteoclasts play a key role in the development of cancer-associated osteolytic lesions. The number and activity of osteoclasts are often enhanced by tumors. However, the origin of osteoclasts is unknown.
Junling Zhuang +6 more
doaj +2 more sources
The effect of cytokines on osteoblasts and osteoclasts in bone remodeling in osteoporosis: a review
Frontiers in Immunology, 2023 The complicated connections and cross talk between the skeletal system and the immune system are attracting more attention, which is developing into the field of Osteoimmunology.
Jie Xu, +4 more
semanticscholar +1 more source
Osteoclasts, Master Sculptors of Bone.
Annual Review of Pathology, 2022 Osteoclasts are multinucleated cells with the unique ability to resorb bone matrix. Excessive production or activation of osteoclasts leads to skeletal pathologies that affect a significant portion of the population.
D. Veis, C. O’Brien
semanticscholar +1 more source
Osteopontin--a possible anchor of osteoclasts to bone. [PDF]
Proceedings of the National Academy of Sciences of the United States of America, 1990 Finn P. Reinholt +3 more
openalex +2 more sources
The origins and roles of osteoclasts in bone development, homeostasis and repair.
Development, 2022 The mechanisms underlying bone development, repair and regeneration are reliant on the interplay and communication between osteoclasts and other surrounding cells.
Yasuhito Yahara +4 more
semanticscholar +1 more source
Ammonia-induced Calcium Phosphate Nanostructure: A Potential Assay for Studying Osteoporosis and Bone Metastasis [PDF]
ACS Applied Materials & Interfaces Manuscript ID:
am-2021-004953.R2, 2021 Osteoclastic resorption of bone plays a central role in both osteoporosis and bone metastasis. A reliable in vitro assay that simulates osteoclastic resorption in vivo would significantly speed up the process of devel-oping effective therapeutic solutions for those diseases. Here we reported the development of a novel and robust nano-structured calcium
arxiv +1 more source
Immunological Medicine, 2022 Rheumatoid arthritis is a chronic form of arthritis that causes bone destruction in joints such as the knees and fingers. Over the past two decades, the clinical outcomes of rheumatoid arthritis have improved substantially with the development of ...
Tomoya Agemura +4 more
doaj +1 more source
This is not an osteoclast [PDF]
Blood, 2016 ![Figure][1] A 64-year-old man with immunoglobulin A κ multiple myeloma was treated initially with bortezomib, thalidomide, dexamethasone, and daratumumab, an anti-CD38 antibody. After 4 cycles, the monoclonal component had decreased from 27 g/L to 8 g/L.
Adriana Plesa, Pierre Sujobert
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