Results 11 to 20 of about 132,467 (326)
Origin of Osteoclasts: Osteoclast Precursor Cells
Journal of Bone Metabolism, 2023 Osteoclasts are multinucleated bone-resorbing cells and a key player in bone remodeling for health and disease. Since the discovery of osteoclasts in 1873, the structure and function of osteoclasts and the molecular and cellular mechanisms of osteoclastogenesis have been extensively studied.
Jefferson Tsai +4 more
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Stem Cell Research & Therapy, 2020 Background Infantile malignant osteopetrosis (IMO) is an autosomal recessive disorder characterized by non-functional osteoclasts and a fatal outcome early in childhood. About 50% of patients have mutations in the TCIRG1 gene.
Xiaojie Xian +7 more
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Osteoclasts and Arthritis [PDF]
Journal of Bone and Mineral Research, 2009 INFLAMMATORY ARTHRITIS TYPICALLY presents as joint pain, swelling, and stiffness, which may be of short duration. For example, parvovirus B 19 infection, attended by painful polyarticular swelling, generally resolves spontaneously within 2 wk without joint destruction.
Georg, Schett, Steven L, Teitelbaum
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Automated Quantification of Human Osteoclasts Using Object Detection
Frontiers in Cell and Developmental Biology, 2022 A balanced skeletal remodeling process is paramount to staying healthy. The remodeling process can be studied by analyzing osteoclasts differentiated in vitro from mononuclear cells isolated from peripheral blood or from buffy coats.
Sampsa Kohtala +9 more
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Centrosome clustering control in osteoclasts through CCR5-mediated signaling
Scientific Reports, 2023 Osteoclasts uniquely resorb calcified bone matrices. To exert their function, mature osteoclasts maintain the cellular polarity and directional vesicle trafficking to and from the resorbing bone surface.
Ji-Won Lee +10 more
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Osteoblast-Osteoclast Communication and Bone Homeostasis
Cells, 2020 Bone remodeling is tightly regulated by a cross-talk between bone-forming osteoblasts and bone-resorbing osteoclasts. Osteoblasts and osteoclasts communicate with each other to regulate cellular behavior, survival and differentiation through direct cell ...
Jung-Min Kim +4 more
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OC_Finder: Osteoclast Segmentation, Counting, and Classification Using Watershed and Deep Learning
Frontiers in Bioinformatics, 2022 Osteoclasts are multinucleated cells that exclusively resorb bone matrix proteins and minerals on the bone surface. They differentiate from monocyte/macrophage lineage cells in the presence of osteoclastogenic cytokines such as the receptor activator of ...
Xiao Wang +9 more
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Electron Microscopic Studying of Rat Bone Cells Under Microgravity Conditions [PDF]
, 2016 In the experiments on rats (SLS-2) with the use of electron microscopy there was made the study of the osteoclasts population and the peculiarities of resorptive processes in a spongy bone of the epiphyses and the iliac crest.The results of investigation
Polkovenko, O. (Olga)
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Arthritis-associated osteoclastogenic macrophage, AtoM, as a key player in pathological bone erosion
Inflammation and Regeneration, 2022 Osteoclasts are myeloid lineage cells with a unique bone-destroying ability that maintains bone homeostasis together with bone formation by osteoblasts.
Tomoya Agemura +4 more
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SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts [PDF]
, 2017 Acknowledgements We sincerely thank the patients and family members who participated in this study. We would also like to thank Stefan Esher, Umeå University, for help with genealogy, and Anna Westerlund for excellent technical assistance.
Ameur, Adam +15 more
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