Results 41 to 50 of about 111,801 (276)

Brucella and Osteoarticular Cell Activation: Partners in Crime [PDF]

, 2017
Osteoarticular brucellosis is the most common presentation of human active disease although its prevalence varies widely. The three most common forms of osteoarticular involvement are sacroiliitis, spondylitis, and peripheral arthritis.
Adamopoulos, Adarichev, Al-Eissa, Aydin, Azuma, Bartok, Behera, Bivi, Bonewald, Burrage, Buzgan, Cenci, Chen, Civitelli, Colmenero, Delpino, Delpino, Delpino, D’Amelio, D’Amelio, El-Jawhari, Farkas, Fuller, Garcia Samartino, Geiger, Giambartolomei, Giambartolomei, Gilmore, Goenka, Goenka, Golding, Gotuzzo, Grundt, Haynes, Horowitz, Ibero, Ikeda, Inman, Karner, Kasim, Kawai, Kitazawa, Kobayashi, Kollet, Kong, Kotake, Lacey, Lampiasi, Lerner, Madkour, Madkour, Magnani, Merkel, Milner, Mori, Nair, Nakayamada, Pappas, Pappas, Pesce Viglietti, Press, Prideaux, Rajapakse, Rajashekara, Rodan, Roggia, Sato, Scian, Scian, Scian, Scian, Shaalan, Skyberg, Soder, Song, Streuli, Takayanagi, Takayanagi, Takayanagi, Tanaka, Teitelbaum, Thomson, Tokoyoda, Turan, Viau, Visnjic, Wallach, Wei, Yasuda, Young, Young, Zhan, Zhan, Zhan, Zhao, Zwerdling   +95 more
core   +1 more source

Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion

Biology, 2023
We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (Lrrk1) gene were osteopetrotic due to the failure of osteoclasts to resorb bone.
Sandi Shen, Mingjue Si, Canjun Zeng, Elaine K. Liu, Yian Chen, Jean Vacher, Haibo Zhao, Subburaman Mohan, Weirong Xing   +8 more
doaj   +1 more source

Impact of Janus Kinase Inhibition with Tofacitinib on Fundamental Processes of Bone Healing [PDF]

, 2020
Both inflammatory diseases like rheumatoid arthritis (RA) and anti-inflammatory treatment of RA with glucocorticoids (GCs) or non-steroidal anti-inflammatory drugs (NSAIDs) negatively influence bone metabolism and fracture healing.
Brinkman, Antonia Clara Katharina, Burmester, Gerd-Rüdiger, Buttgereit, Frank, Damerau, Alexandra, Diesing, Karoline, Gaber, Timo, Hoff, Paula, Lang, Annemarie, Ohrndorf, Sarah, Pfeiffenberger, Moritz, Pienczikowski, Justyna   +10 more
core   +1 more source

Regulation of Osteoclast Differentiation by Myosin X

Scientific Reports, 2017
Osteoclasts begin as mononuclear cells that fuse to form multinuclear cells able to resorb bone. The mechanisms that regulate all the steps of osteoclast differentiation are not entirely known.
Amy Tasca, Kristina Astleford, Ari Lederman, Eric D. Jensen, Beth S. Lee, Rajaram Gopalakrishnan, Kim C. Mansky   +6 more
doaj   +1 more source

THOC5 regulates human osteoclastogenesis

European Journal of Cell Biology, 2022
Osteoclasts are bone resorbing cells that are responsible for physiological and pathological bone resorption. Macrophage colony stimulating factor (M-CSF) binds to the M-CSF receptor (c-FMS) and plays a key role in the differentiation and survival of ...
Se Hwan Mun, Brian Oh, Min Joon Lee, Seyeon Bae, Young Yang, Kyung-Hyun Park-Min   +5 more
doaj   +1 more source

Remodeling Of The Bone Tissue Of Rats Of Different Lines After Melatonin Effect [PDF]

, 2016
The markers of remodeling of bone tissue (BT) were studied after the impact of pharmacologic dose of melatonin (5 mg/kg of the animal body weight) during 28 days for 3-months rats-males of Wistar and SHR lines.
Berezovskyi, V. (Vadim), Litovka, I. (Irina), Zhernoklov, U. (Uliana)   +2 more
core   +2 more sources

Tumor Necrosis Factor-α Produced by Osteoclasts Might Induce Intractable Pain in a Rat Spinal Metastasis Model of Breast Cancer

Spine Surgery and Related Research, 2019
Introduction: Causes of pain due to spinal metastases have been insufficiently investigated. Tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6) were the focus of this study.
Ai Mazaki, Sumihisa Orita, Kazuhide Inage, Miyako Suzuki, Kohki Abe, Yasuhiro Shiga, Masahiro Inoue, Masaki Norimoto, Tomotaka Umimura, Seiji Ohtori, Kazuyo Yamauchi   +10 more
doaj   +1 more source

Biointerface Membranes Orchestrating Site‐Specific Osteoimmunomodulatory and Antibacterial Effects for Enhanced Osseous Regeneration in Periodontal Therapy

Advanced Functional Materials, EarlyView.
Here, a biointerface membrane engineered with site‐specific interfacial properties is developed. During implantation between gingival and bone defect, the membrane creates a pro‐osteogenic microenvironment, precisely modulates cellular activities at each biointerface, and facilitates the orchestration of complex healing events, ultimately leading to ...
Yuwei Zhu, Tingting Wang, Jing Zhu, Bingtian Zhao, Bingyang Dai, Xiaoyue Zhang, Wei Liu, Cheng Yang, Cheng Dong, Ren Liu, Lei Zhao, Jun Wang, Peilei Shi, To Ngai   +13 more
wiley   +1 more source

Preventive CCL2/CCR2 Axis Blockade Suppresses Osteoclast Activity in a Mouse Model of Rheumatoid Arthritis by Reducing Homing of CCR2hi Osteoclast Progenitors to the Affected Bone

Frontiers in Immunology, 2021
Detailed characterization of medullary and extramedullary reservoirs of osteoclast progenitors (OCPs) is required to understand the pathophysiology of increased periarticular and systemic bone resorption in arthritis.
Darja Flegar, Darja Flegar, Maša Filipović, Maša Filipović, Alan Šućur, Alan Šućur, Antonio Markotić, Antonio Markotić, Nina Lukač, Nina Lukač, Dino Šisl, Dino Šisl, Marina Ikić Matijašević, Zrinka Jajić, Tomislav Kelava, Tomislav Kelava, Vedran Katavić, Vedran Katavić, Nataša Kovačić, Nataša Kovačić, Danka Grčević, Danka Grčević   +21 more
doaj   +1 more source

Ascorbic Acid Modulates Collagen Properties in Glucocorticoid‐Induced Osteoporotic Bone: Insights into Chemical, Mechanical, and Biological Regulation

Advanced Healthcare Materials, EarlyView.
Osteoporosis from long‐term glucocorticoid (GIOP) use elevates susceptibility to fracture. This study shows GCs impair ascorbic acid (AA) metabolism in osteoblasts, collagen synthesis and extracellular matrix integrity. AA enhanced collagen biochemical and mechanical properties and restored osteoblast and endothelial function. These findings underscore
Micaila DE Curtis, Yoontae Kim, Rahul Patil, Xinran Zhang, Meth Jayatilake, Orelle Bulgin, Peter Lialios, Sana Surrency, Soraya Tarrah, Argyris K. Lazaris, Alison Grafton, James Williams IV, Seyedeh Boshra Nouraie, Maria Bizaki, Penelope Xeron, Edward Van Keuren, Jonathan E. Seppala, Evagelia C. Laiakis, Joanna B. Kitlinska, Stella Alimperti   +19 more
wiley   +1 more source