Results 41 to 50 of about 109,289 (351)
Simulating pharmaceutical treatment effects on osteoporosis via a bone remodeling algorithm targeting hypermineralized sites [PDF]
Medical Engineering and Physics, Elsevier, 2020, 76, pp.56 - 68, 2021 Pharmaceutical treatments can slow bone degradation, thus reducing the fracture risk inherent in osteoporosis. Antiresorptive treatments block the over-activation of osteoclasts vs osteoblasts, but the resulting decrease in bone remodeling frequency may weaken bone structure over time, with no gain in bone volume.
arxiv +1 more source
BMC Musculoskeletal Disorders, 2010 Background Bone resorption is initiated by osteoclastic acidification of the resorption lacunae. This process is mediated by secretion of protons through the V-ATPase and chloride through the chloride antiporter ClC-7.
Boutin Jean A +5 more
doaj +1 more source
Frontiers in Cell and Developmental Biology, 2020 Tumor necrosis factor-alpha (TNF-α) promotes osteoclasts differentiation to enhance bone resorption and inhibits osteoblasts differentiation to impair bone formation, which plays a central role in the development of postmenopausal osteoporosis (PMOP ...
Zhuochao Liu +9 more
doaj +1 more source
Break and then stand: novel insight into osteoclast functions in the skeletal system
Di-san junyi daxue xuebao, 2022 The skeleton provides the scaffold to support body weight, enable body movement, control mineral homeostasis, and provide the location for hematopoiesis.
DONG Shiwu, HU Wenhui
doaj +1 more source
Osteoclast differentiation from human blood precursors on biomimetic calcium-phosphate substrates [PDF]
, 2017 The design of synthetic bone grafts to foster bone formation is a challenge in regenerative medicine. Understanding the interaction of bone substitutes with osteoclasts is essential, since osteoclasts not only drive a timely resorption of the biomaterial,
Avnet, Sofia +7 more
core +2 more sources
Osteoclast Fusion and Fission [PDF]
Calcified Tissue International, 2012 Osteoclasts are specialized multinucleated cells with the unique capacity to resorb bone. Despite insight into the various steps of the interaction of osteoclast precursors leading to osteoclast formation, surprisingly little is known about what happens with the multinucleated cell itself after it has been formed.
Jansen, I.D.C. +4 more
openaire +10 more sources
Hormone-stimulated modulation of endocytic trafficking in osteoclasts [PDF]
, 2012 Copyright @ 2012 Stenbeck, Lawrence and Albert. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in other forums, provided the original authors and ...
Albert, AP, Lawrence, KM, Stenbeck, G
core +2 more sources
Bone Research, 2018 The skeleton is a dynamic organ that is constantly remodeled. Proteins secreted from bone cells, namely osteoblasts, osteocytes, and osteoclasts exert regulation on osteoblastogenesis, osteclastogenesis, and angiogenesis in a paracrine manner ...
Yujiao Han +4 more
semanticscholar +1 more source
SNX10 gene mutation leading to osteopetrosis with dysfunctional osteoclasts [PDF]
, 2017 Acknowledgements We sincerely thank the patients and family members who participated in this study. We would also like to thank Stefan Esher, Umeå University, for help with genealogy, and Anna Westerlund for excellent technical assistance.
Ameur, Adam +15 more
core +1 more source
Silicon substituted hydroxyapatite/VEGF scaffolds stimulate bone regeneration in osteoporotic sheep [PDF]
Acta Biomaterialia 101, 544-553 (2019), 2021 Silicon-substituted hydroxyapatite (SiHA) macroporous scaffolds have been prepared by robocasting. In order to optimize their bone regeneration properties, we have manufactured these scaffolds presenting different microstructures: nanocrystalline and crystalline. Moreover, their surfaces have been decorated with vascular endothelial growth factor (VEGF)
arxiv +1 more source