Results 51 to 60 of about 109,289 (351)

Osteoclasts and hematopoiesis [PDF]

BoneKEy Reports, 2012
The skeletal tissue is closely associated with the hematopoietic tissue lodged in its inner cavities. Besides the well-known role of the endosteal osteoblasts in the maintenance of the hematopoietic stem cell (HSC) niche, it is an emerging concept that osteoclasts are involved in the regulation of hematopoiesis as well, although published data are ...
openaire   +4 more sources

Subchondral bone osteoclasts induce sensory innervation and osteoarthritis pain

Journal of Clinical Investigation, 2019
Joint pain is the defining symptom of osteoarthritis (OA) but its origin and mechanisms remain unclear. Here, we investigated an unprecedented role of osteoclast-initiated subchondral bone remodeling in sensory innervation for OA pain.
Shouan Zhu, Jianxi Zhu, G. Zhen, Yihe Hu, Senbo An, Yusheng Li, Q. Zheng, Zhiyong Chen, Ya Yang, M. Wan, R. Skolasky, Yong Cao, Tianding Wu, Bo Gao, Mi Yang, Manman Gao, J. Kuliwaba, Shuangfei Ni, Lei Wang, Chuanlong Wu, D. Findlay, H. Eltzschig, Ou Hong, Janet L. Crane, Feng-Quan Zhou, Y. Guan, Xinzhong Dong, Xu Cao   +27 more
semanticscholar   +1 more source

Leucine Repeat Rich Kinase 1 Controls Osteoclast Activity by Managing Lysosomal Trafficking and Secretion

Biology, 2023
We previously demonstrated that mice with targeted deletion of the leucine repeat rich kinase 1 (Lrrk1) gene were osteopetrotic due to the failure of osteoclasts to resorb bone.
Sandi Shen, Mingjue Si, Canjun Zeng, Elaine K. Liu, Yian Chen, Jean Vacher, Haibo Zhao, Subburaman Mohan, Weirong Xing   +8 more
doaj   +1 more source

Antibiotics with Interleukin-15 inhibition reduces joint inflammation and bone erosions but not cartilage destruction in Staphylococcus aureus-induced arthritis [PDF]

, 2018
Background: Staphylococcus aureus-induced arthritis causes rapid joint destruction, often leading to disabling joint damage despite antibiotics. We have previously shown that IL-15 inhibition without antibiotics is beneficial in S.
Bergmann, Berglind, Gjertsson, Inger, Henning, Petra, Jirholt, Pernilla, Lerner, Ulf H., Lindholm, Catharina, McInnes, Iain B., Ohlsson, Claes   +7 more
core   +1 more source

Interleukin-32 Promotes Osteoclast Differentiation but Not Osteoclast Activation [PDF]

PLoS ONE, 2009
Interleukin-32 (IL-32) is a newly described cytokine produced after stimulation by IL-2 or IL-18 and IFN-gamma. IL-32 has the typical properties of a pro-inflammatory mediator and although its role in rheumatoid arthritis has been recently reported its effect on the osteoclastogenesis process remains unclear.In the present study, we have shown that IL ...
Mabilleau, Guillaume, Sabokbar, Afsie
openaire   +6 more sources

Activated γδ T cells inhibit osteoclast differentiation and resorptive activity in vitro [PDF]

, 2013
Peer reviewedPublisher ...
Pappalardo, A., Thompson, K.
core   +1 more source

Erythromyeloid progenitors give rise to a population of osteoclasts contributing to bone homeostasis and repair

Nature Cell Biology, 2019
Osteoclasts are multinucleated cells of the monocyte/macrophage lineage that degrade bone. Here, we used lineage tracing studies—labelling cells expressing Cx3cr1 , Csf1r or Flt3 —to identify the precursors of osteoclasts in mice.
Yasuhito Yahara, T. Barrientos, Yuning J. Tang, V. Puviindran, P. Nadesan, Hongyuan Zhang, Jason R. Gibson, S. Gregory, Yarui Diao, Yu Xiang, Y. Qadri, Tomokazu Souma, M. Shinohara, B. Alman   +13 more
semanticscholar   +1 more source

The Beta-Tubulin Isotype TUBB6 Controls Microtubule and Actin Dynamics in Osteoclasts

Frontiers in Cell and Developmental Biology, 2021
Osteoclasts are bone resorbing cells that participate in the maintenance of bone health. Pathological increase in osteoclast activity causes bone loss, eventually resulting in osteoporosis.
Justine Maurin, Anne Morel, David Guérit, Julien Cau, Serge Urbach, Anne Blangy, Guillaume Bompard   +6 more
doaj   +1 more source

Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice

Nature Communications, 2019
Spinal pain is a major clinical problem, however, its origins and underlying mechanisms remain unclear. Here we report that in mice, osteoclasts induce sensory innervation in the porous endplates which contributes to spinal hypersensitivity in mice ...
Shuangfei Ni, Zemin Ling, Xiao Wang, Yong Cao, Tianding Wu, R. Deng, Janet L. Crane, R. Skolasky, S. Demehri, G. Zhen, Amit Jain, Panfeng Wu, Dayu Pan, Bo Hu, Xiao Lyu, YuSheng Li, Hao Chen, Huabin Qi, Y. Guan, Xinzhong Dong, M. Wan, X. Zou, Hongbin Lu, Jianzhong Hu, Xu Cao   +24 more
semanticscholar   +1 more source

Activation of the P2Y2 receptor regulates bone cell function by enhancing ATP release [PDF]

, 2017
Bone cells constitutively release ATP into the extracellular environment where it acts locally via P2 receptors to regulate bone cell function. Whilst P2Y2 receptor stimulation regulates bone mineralisation, the functional effects of this receptor in ...
Arnett, T R, Gueneri, D, Hajjawai, M O, Orriss, I R, Patel, J J, Shaw, K   +5 more
core   +2 more sources