Results 51 to 60 of about 111,801 (276)

Investigation of bone resorption within a cortical basic multicellular unit using a lattice-based computational model

, 2011
In this paper we develop a lattice-based computational model focused on bone resorption by osteoclasts in a single cortical basic multicellular unit (BMU).
Anderson, Baron, Beysens, Block, Boyce, Boyde, Britz, Bronckers, Buenzli, Burger, Chambers, Civitelli, Cohen, Cooper, David W. Smith, Drasdo, Drasdo, Everts, Frost, Frost, Fukushima, García-Aznar, Gerlee, Ghaemi, Glauber, Glazier, Grynpas, Helfrich, Huang, Jaworski, Jeon, Junhwan Jeon, Manolagas, Mansury, Markus, Martin, Martin, Martin, Martin, Martin, Matsuoka, Miller, Mombach, Moshin, Nishiyama, Noble, Othmer, Othmer, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Parfitt, Pascal R. Buenzli, Peruani, Peter Pivonka, Peter T. Cummings, Poplawski, Robling, Roodman, Ryser, Schienbein, Schilling, Schweitzer, Stout, Susa, Tappen, van Kampen, van Oers, van Oers, Väänänen, Walker, Zhang   +74 more
core   +2 more sources

Analysis of Nkx3.1:Cre-driven Erk5 deletion reveals a profound spinal deformity which is linked to increased osteoclast activity [PDF]

, 2017
Extracellular signal-regulated protein kinase 5 (ERK5) has been implicated during development and carcinogenesis. Nkx3.1-mediated Cre expression is a useful strategy to genetically manipulate the mouse prostate. While grossly normal at birth, we observed
Ahmad, Imran, Blyth, Karen, Charlesworth, Gemma, Daroszewska, Anna, Ford, Catriona, King, Ayala, Leung, Hing Y., Loveridge, Carolyn J., Mui, Ernest J., Prior, Amanda, Rose, Lorraine, Salji, Mark, Sansom, Owen, Tan, Ee Hong, van ’t Hof, Rob J., Welsh, Michelle   +15 more
core   +2 more sources

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, EarlyView.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source

Bone matrix components activate the NLRP3 inflammasome and promote osteoclast differentiation [PDF]

, 2017
The NLRP3 inflammasome senses a variety of signals referred to as danger associated molecular patterns (DAMPs), including those triggered by crystalline particulates or degradation products of extracellular matrix. Since some DAMPs confer tissue-specific
Abu-Amer, Yousef, Alippe, Yael, Civitelli, Roberto, Mbalaviele, Gabriel, Novack, Deborah V, Qu, Chao, Ricci, Biancamaria, Wang, Chun, Xiao, Jianqiu, Zou, Wei   +9 more
core   +2 more sources

Characterization of an Injectable Poly(vinyl alcohol)‐gelatin Hydrogel for Growth Factor Delivery in an Orthopedic Application

Advanced Healthcare Materials, EarlyView.
This work introduces photo‐crosslinkable tyraminated poly(vinyl alcohol)‐gelatin (PVA‐GT) hydrogels as tunable injectable platforms for tissue engineering and growth factor delivery applications. This schematic illustrates the two developed hydrogel formulations and the experimental workflow used to evaluate their physico‐chemical properties in vitro ...
Alessia Longoni, Gretel S. Major, Sam Arnold, Samuel Tomkins, Eugenia Spessot, Scott Loeffler, Kieran Lau, Richard Tan, Jessica Harte, Roslyn Kemp, Tess Reynolds, Jelena Rnjak‐Kovacina, Gary J. Hooper, Tim B. F. Woodfield, David C. Kieser, Khoon S. Lim   +15 more
wiley   +1 more source

Osteoblast–osteoclast interactions [PDF]

Connective Tissue Research, 2017
Bone homeostasis depends on the resorption of bones by osteoclasts and formation of bones by the osteoblasts. Imbalance of this tightly coupled process can cause diseases such as osteoporosis. Thus, the mechanisms that regulate communication between osteoclasts and osteoblasts are critical to bone cell biology.
Xiao, Chen, Zhongqiu, Wang, Na, Duan, Guoying, Zhu, Edward M, Schwarz, Chao, Xie   +5 more
openaire   +2 more sources

The unbearable lightness of bone marrow homeostasis [PDF]

, 2015
The anatomical and functional dimensions of bone marrow topography have been at the forefront of modern bone and immunological research for many years and remain a source of complexity and perplexity due to the multitude of microhabitats within this ...
AGAS, DIMITRIOS, Douni E., MARCHETTI, Luigi, SABBIETI, Maria Giovanna   +3 more
core   +1 more source

Bone Healing Around Implants in Normal and Medically Compromised Conditions: Osteoporosis and Diabetes

Advanced Healthcare Materials, EarlyView.
xx xx. ABSTRACT Osseointegration of orthopedic and dental implants is influenced by local and systemic factors, including their physicochemical surface properties and the patient's overall health status. Titanium and its alloys have been a longstanding standard for bone implants due to their innate biocompatibility and mechanical properties.
Dainelys Guadarrama Bello, Fabio Variola, Antonio Nanci   +2 more
wiley   +1 more source

The emerging role of osteoclasts in the treatment of bone metastases: rationale and recent clinical evidence

Frontiers in Oncology
The occurrence of bone metastasis is a grave medical concern that substantially impacts the quality of life in patients with cancer. The precise mechanisms underlying bone metastasis remain unclear despite extensive research efforts, and efficacious ...
Youjun Liu, Huanshi Chen, Tong Chen, Guowen Qiu, Yu Han   +4 more
doaj   +1 more source

Osteoclasts and their circulating precursors in rheumatoid arthritis: Relationships with disease activity and bone erosions

Bone Reports, 2020
Patients with rheumatoid arthritis (RA) have very different outcomes, particularly with regard to bone erosions. Since osteoclasts are responsible for bone destruction adjacent to rheumatoid synovium, profiling osteoclasts from circulating precursors in ...
H. Allard-Chamard, N. Carrier, P. Dufort, M. Durand, A.J. de Brum-Fernandes, G. Boire, S.V. Komarova, S.J. Dixon, R.E. Harrison, M.F. Manolson, S. Roux   +10 more
doaj   +1 more source